Altered Expression of Somatostatin Receptors in Pancreatic Islets from NOD Mice Cultured at Different Glucose Concentrations In Vitro and in Islets Transplanted to Diabetic NOD Mice In Vivo

Somatostatin acts via five receptors (sst1–5). We investigated if the changes in pancreatic islet sst expression in diabetic NOD mice compared to normoglycemic mice are a consequence of hyperglycemia or the ongoing immune reaction in the pancreas. Pancreatic islets were isolated from NOD mice precultured for 5 days and further cultured for 3 days at high or low glucose before examined. Islets were also isolated from NOD mice and transplanted to normal or diabetic mice in a number not sufficient to cure hyperglycemia. After three days, the transplants were removed and stained for sst1–5 and islet hormones. Overall, changes in sst islet cell expression were more common in islets cultured in high glucose concentration in vitro as compared to the islet transplantation in vivo to diabetic mice. The beta and PP cells exhibited more frequent changes in sst expression, while the alpha and delta cells were relatively unaffected by the high glucose condition. Our findings suggest that the glucose level may alter sst expressed in islets cells; however, immune mechanisms may counteract such changes in islet sst expression

On certain quasi-local spin-angular momentum expressions for small spheres

The Ludvigsen-Vickers and two recently suggested quasi-local spin-angular momentum expressions, based on holomorphic and anti-holomorphic spinor fields, are calculated for small spheres of radius $r$ about a point $o$. It is shown that, apart from the sign in the case of anti-holomorphic spinors in non-vacuum, the leading terms of all these expressions coincide. In non-vacuum spacetimes this common leading term is of order $r^4$, and it is the product of the contraction of the energy-momentum tensor and an average of the approximate boost-rotation Killing vector that vanishes at $o$ and of the 3-volume of the ball of radius $r$. In vacuum spacetimes the leading term is of order $r^6$, and the factor of proportionality is the contraction of the Bel-Robinson tensor and an other average of the same approximate boost-rotation Killing vector.Comment: 16 pages, Plain Te

Positive Mass Theorem for Black Holes in Einstein-Maxwell Axion-dilaton Gravity

We presented the proof of the positive mass theorem for black holes in Einstein-Maxwell axion-dilaton gravity being the low-energy limit of the heterotic string theory. We show that the total mass of a spacetime containing a black hole is greater or equal to the square root of the sum of squares of the adequate dilaton-electric and dilaton-axion charges.Comment: latex file, to appear in Classical Quantum Gravit

Trapped surfaces and the Penrose inequality in spherically symmetric geometries

We demonstrate that the Penrose inequality is valid for spherically symmetric geometries even when the horizon is immersed in matter. The matter field need not be at rest. The only restriction is that the source satisfies the weak energy condition outside the horizon. No restrictions are placed on the matter inside the horizon. The proof of the Penrose inequality gives a new necessary condition for the formation of trapped surfaces. This formulation can also be adapted to give a sufficient condition. We show that a modification of the Penrose inequality proposed by Gibbons for charged black holes can be broken in early stages of gravitational collapse. This investigation is based exclusively on the initial data formulation of General Relativity.Comment: plain te

Two dimensional Sen connections in general relativity

The two dimensional version of the Sen connection for spinors and tensors on spacelike 2-surfaces is constructed. A complex metric $\gamma_{AB}$ on the spin spaces is found which characterizes both the algebraic and extrinsic geometrical properties of the 2-surface $\$$. The curvature of the two dimensional Sen operator $\Delta_e$ is the pull back to $\$$ of the anti-self-dual part of the spacetime curvature while its `torsion' is a boost gauge invariant expression of the extrinsic curvatures of $\$$. The difference of the 2 dimensional Sen and the induced spin connections is the anti-self-dual part of the `torsion'. The irreducible parts of $\Delta_e$ are shown to be the familiar 2-surface twistor and the Weyl--Sen--Witten operators. Two Sen--Witten type identities are derived, the first is an identity between the 2 dimensional twistor and the Weyl--Sen--Witten operators and the integrand of Penrose's charge integral, while the second contains the `torsion' as well. For spinor fields satisfying the 2-surface twistor equation the first reduces to Tod's formula for the kinematical twistor.Comment: 14 pages, Plain Tex, no report numbe

Quasi-Local Gravitational Energy

A dynamically preferred quasi-local definition of gravitational energy is given in terms of the Hamiltonian of a `2+2' formulation of general relativity. The energy is well-defined for any compact orientable spatial 2-surface, and depends on the fundamental forms only. The energy is zero for any surface in flat spacetime, and reduces to the Hawking mass in the absence of shear and twist. For asymptotically flat spacetimes, the energy tends to the Bondi mass at null infinity and the \ADM mass at spatial infinity, taking the limit along a foliation parametrised by area radius. The energy is calculated for the Schwarzschild, Reissner-Nordstr\"om and Robertson-Walker solutions, and for plane waves and colliding plane waves. Energy inequalities are discussed, and for static black holes the irreducible mass is obtained on the horizon. Criteria for an adequate definition of quasi-local energy are discussed.Comment: 16 page

A Mass Bound for Spherically Symmetric Black Hole Spacetimes

Requiring that the matter fields are subject to the dominant energy condition, we establish the lower bound $(4\pi)^{-1} \kappa {\cal A}$ for the total mass $M$ of a static, spherically symmetric black hole spacetime. (${\cal A}$ and $\kappa$ denote the area and the surface gravity of the horizon, respectively.) Together with the fact that the Komar integral provides a simple relation between $M - (4\pi)^{-1} \kappa A$ and the strong energy condition, this enables us to prove that the Schwarzschild metric represents the only static, spherically symmetric black hole solution of a selfgravitating matter model satisfying the dominant, but violating the strong energy condition for the timelike Killing field $K$ at every point, that is, $R(K,K) \leq 0$. Applying this result to scalar fields, we recover the fact that the only black hole configuration of the spherically symmetric Einstein-Higgs model with arbitrary non-negative potential is the Schwarzschild spacetime with constant Higgs field. In the presence of electromagnetic fields, we also derive a stronger bound for the total mass, involving the electromagnetic potentials and charges. Again, this estimate provides a simple tool to prove a ``no-hair'' theorem for matter fields violating the strong energy condition.Comment: 16 pages, LATEX, no figure

Gas filled photonic bandgap fibers as wavelength references

Abstract We demonstrate that air-guiding photonic bandgap fibers filled with various gases, such as acetylene and methane provide optical wavelength references. The constructed devices are compact and cost-effective

Lagrangian and Hamiltonian for the Bondi-Sachs metrics

We calculate the Hilbert action for the Bondi-Sachs metrics. It yields the Einstein vacuum equations in a closed form. Following the Dirac approach to constrained systems we investigate the related Hamiltonian formulation.Comment: 8 page