Relativistic Radiative Transfer for Spherical Flows

We present a new complete set of Lagrangian relativistic hydrodynamical equations describing the transfer of energy and momentum between a standard fluid and a radiation fluid in a general non-stationary spherical flow. The new set of equations has been derived for a particular application to the study of the cosmological Quark--Hadron transition but can also be used in other contexts.Comment: 28 pages, 9 postscript figs, Plain Te

Discretized Diffusion Processes

We study the properties of the ``Rigid Laplacian'' operator, that is we consider solutions of the Laplacian equation in the presence of fixed truncation errors. The dynamics of convergence to the correct analytical solution displays the presence of a metastable set of numerical solutions, whose presence can be related to granularity. We provide some scaling analysis in order to determine the value of the exponents characterizing the process. We believe that this prototype model is also suitable to provide an explanation of the widespread presence of power-law in social and economic system where information and decision diffuse, with errors and delay from agent to agent.Comment: 4 pages 5 figure, to be published in PR

Merger time scale of galaxies

Abstract. In this talk, we present our recent study of galaxy mergers in a high-resolution cosmological hydro/N-body simulation with star formation, and compare the measured merger timescales with theoretical predictions based on the Chandrasekhar formula. In contrast to Navarro et al., our numerical results indicate, that the commonly used equation for the merger timescale given by Lacey and Cole, systematically underestimates the merger timescales for minor mergers and overestimates those for major mergers. This behavior is partly explained by the poor performance of their expression for the Coulomb logarithm, ln(/Wpri//Wsat). The two alternative forms ln(l +/Wpri//Wsat) and l/2In[l + [m^^/msnt) ] for the Coulomb logarithm can account for the mass dependence of merger timescale successfiilly, but both of them underestimate the merger time scale by a factor 2. Since ln(l + /Wpn/msat) represents the mass dependence slightly better we adopt this expression for the Coulomb logarithm. Furthermore, we find that the dependence of the merger timescale on the circularity parameter e is much weaker than the widely adopted power-law e, whereas 0.94 * e"" " + 0.60 provides a good match to the data. Based on these findings, we present an accurate and convenient fitting formula for the merger timescale of galaxies in cold dark matter models

Oral anticoagulant decreases stroke recurrence in patients with atrial fibrillation detected after stroke

Background: Atrial fibrillation detected after stroke (AFDAS) has a lower risk of ischemic stroke recurrence than known atrial fibrillation (KAF). While the benefit of oral anticoagulants (OAC) for preventing ischemic stroke recurrence in KAF is well established, their role in patients with AFDAS is more controversial. This study aimed to evaluate the association between OAC use and the risk of recurrent ischemic stroke in patients with AFDAS in a real-world setting. Methods: This nationwide retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database. Patients hospitalized with a first-ever ischemic stroke and AFDAS confirmed within 30 days after hospitalization were assigned to OAC and non-OAC cohorts. Inverse probability of treatment weighting was applied to balance the baseline characteristics of the cohorts. The primary outcome was ischemic stroke recurrence. Secondary outcomes were intracranial hemorrhage (ICH), death, and the composite outcome of “ischemic stroke recurrence, ICH, or death.” Multivariate Cox proportional hazard models were used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI). Results: A total of 4,508 hospitalized patients with stroke and AFDAS were identified. Based on OAC use, 2,856 and 1,652 patients were assigned to the OAC and non-OAC groups, respectively. During the follow-up period (median duration, 2.76 years), the OAC cohort exhibited a lower risk of ischemic stroke recurrence (aHR, 0.84; 95% CI, 0.70–0.99), death (aHR, 0.65; 95% CI, 0.58–0.73), and composite outcome (aHR, 0.70; 95% CI, 0.63–0.78) than did the non-OAC cohort. The risk of ICH (aHR, 0.96; 95% CI, 0.62–1.50) was not significantly different between the two cohorts. Conclusion: OAC use in patients with AFDAS was associated with reduced risk of ischemic stroke recurrence, without an increased risk of ICH. This supports current guidelines recommending OACs for secondary stroke prevention in patients with AF, regardless of the time of diagnosis

Baryon number segregation at the end of the cosmological quark-hadron transition

One of the most interesting questions regarding a possible first order cosmological quark--hadron phase transition concerns the final fate of the baryon number contained within the disconnected quark regions at the end of the transition. We here present a detailed investigation of the hydrodynamical evolution of an evaporating quark drop, using a multi-component fluid description to follow the mechanisms of baryon number segregation. With this approach, we are able to take account of the simultaneous effects of baryon number flux suppression at the phase interface, entropy extraction by means of particles having long mean-free-paths, and baryon number diffusion. A range of computations has been performed to investigate the permitted parameter-space and this has shown that significant baryon number concentrations, perhaps even up to densities above that of nuclear matter, represent an inevitable outcome within this scenario.Comment: 33 pages, Latex file, 6 postscript figures included in the text (psfig.tex). To appear in Phys. Rev. D1

Role of STAT3 pathway in genitourinary tumors

The STAT3 is often dysregulated in genitourinary tumors. In prostate cancer, STAT3 activation correlates with Gleason score and pathological stage and modulates cancer stem cells and epithelial-mesenchymal transition. In addition, STAT3 promotes the progression from carcinoma in situ to invasive bladder cancer and modulates renal cell carcinoma angiogenesis by increasing the expression of HIF1α and VEGF. STAT3 is also involved in the response to tyrosine kinase inhibitors sunitinib and axitinib, in patients with metastatic renal cell carcinoma, and to second-generation androgen receptor inhibitor enzalutamide in patients with advanced prostate cancer. In this review, we describe the role of STAT3 in genitourinary tumors, thus describing its potential for future therapeutic strategies

Oral anticoagulant decreases stroke recurrence in patients with atrial fibrillation detected after stroke

BackgroundAtrial fibrillation detected after stroke (AFDAS) has a lower risk of ischemic stroke recurrence than known atrial fibrillation (KAF). While the benefit of oral anticoagulants (OAC) for preventing ischemic stroke recurrence in KAF is well established, their role in patients with AFDAS is more controversial. This study aimed to evaluate the association between OAC use and the risk of recurrent ischemic stroke in patients with AFDAS in a real-world setting.MethodsThis nationwide retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database. Patients hospitalized with a first-ever ischemic stroke and AFDAS confirmed within 30 days after hospitalization were assigned to OAC and non-OAC cohorts. Inverse probability of treatment weighting was applied to balance the baseline characteristics of the cohorts. The primary outcome was ischemic stroke recurrence. Secondary outcomes were intracranial hemorrhage (ICH), death, and the composite outcome of “ischemic stroke recurrence, ICH, or death.” Multivariate Cox proportional hazard models were used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI).ResultsA total of 4,508 hospitalized patients with stroke and AFDAS were identified. Based on OAC use, 2,856 and 1,652 patients were assigned to the OAC and non-OAC groups, respectively. During the follow-up period (median duration, 2.76 years), the OAC cohort exhibited a lower risk of ischemic stroke recurrence (aHR, 0.84; 95% CI, 0.70–0.99), death (aHR, 0.65; 95% CI, 0.58–0.73), and composite outcome (aHR, 0.70; 95% CI, 0.63–0.78) than did the non-OAC cohort. The risk of ICH (aHR, 0.96; 95% CI, 0.62–1.50) was not significantly different between the two cohorts.ConclusionOAC use in patients with AFDAS was associated with reduced risk of ischemic stroke recurrence, without an increased risk of ICH. This supports current guidelines recommending OACs for secondary stroke prevention in patients with AF, regardless of the time of diagnosis

Hydrodynamics of the Cosmological Quark-Hadron Transition in the Presence of Long-Range Energy and Momentum Transfer

Two previous papers in this series have presented a study of the growth of hadronic bubbles during the cosmological Quark--Hadron transition, treating the material within each phase as a single perfect fluid. Here, we extend the analysis to include the effects of long-range energy and momentum transfer by weakly and electromagnetically interacting particles. After a short review of the formalism adopted, we discuss the numerical strategies used in the computer code which has been constructed in order to solve this system of equations. Results for the growth of single hadronic bubbles are also presented.Comment: 21 pages, Plain Tex, nofigures. uucoded file containing the postcript version of the paper and 9 figures is available on a separate fil

Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium.

Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P < 0.0001), lower modularity (P < 0.0001), and lower small-worldness (P = 0.017). Detection of community membership emphasized lower network segregation in OCD compared to healthy controls. At the regional level, there were lower (rank-transformed) centrality values in OCD for volume of caudate nucleus and thalamus, and surface area of paracentral cortex, indicative of altered distribution of brain hubs. Centrality of cingulate and orbito-frontal as well as other brain areas was associated with OCD illness duration, suggesting greater involvement of these brain areas with illness chronicity. In summary, the findings of this study, the largest brain structural covariance study of OCD to date, point to a less segregated organization of structural covariance networks in OCD, and reorganization of brain hubs. The segregation findings suggest a possible signature of altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brain development and maturation, particularly in cingulate and orbitofrontal regions