Stress and dislocations in thin metal layers

According to experimental findings there are types of loading for which it is more difficult to plastically deform small metal structures than the corresponding massive metal. This occurs when at least one of the dimensions of the structure is at the micrometer scale or smaller. It is for instance the case of thin metal coatings: the thinner is the film, the more difficult it is to deform it plastically. This feature is in contrast with what expected on the basis of classical plasticity theories, which predict a size-independent mechanical response. In this thesis the size effect in thin films is studied by means of two-dimensional discrete dislocation plasticity. Plasticity is treated as the collective motion of edge dislocations on prescribed slip systems. The framework contains an intrinsic length scale- the dislocation Burgers vector- which is a necessary condition to capture a size effect. ... Zie: Summary

Relaxation of thermal stress by dislocation motion in passivated metal interconnects

The development and relaxation of stress in metal interconnects strained by their surroundings (substrate and passivation layers) is predicted by a discrete dislocation analysis. The model is based on a two-dimensional plane strain formulation, with deformation fully constrained in the line direction. Plastic deformation occurs by glide of edge dislocations on three slip systems in the single crystal line. The substrate and passivation layers are treated as elastic materials, and therefore impenetrable for the dislocations. Results of the simulations show the dependence of the stress evolution and of the effectiveness of plastic relaxation on the geometry of the line. The dependence of stress development on line aspect ratio, line size, slip plane orientation, pitch length and passivation layer thickness are explored.

Transcriptome dynamics in the asexual cycle of the chordate Botryllus schlosseri

Background: We performed an analysis of the transcriptome during the blastogenesis of the chordate Botryllus schlosseri, focusing in particular on genes involved in cell death by apoptosis. The tunicate B. schlosseri is an ascidian forming colonies characterized by the coexistence of three blastogenetic generations: filter-feeding adults, buds on adults, and budlets on buds. Cyclically, adult tissues undergo apoptosis and are progressively resorbed and replaced by their buds originated by asexual reproduction. This is a feature of colonial tunicates, the only known chordates that can reproduce asexually. Results: Thanks to a newly developed web-based platform (http://botryllus.cribi.unipd.it), we compared the transcriptomes of the mid-cycle, the pre-take-over, and the take-over phases of the colonial blastogenetic cycle. The platform is equipped with programs for comparative analysis and allows to select the statistical stringency. We enriched the genome annotation with 11,337 new genes; 581 transcripts were resolved as complete open reading frames, translated in silico into amino acid sequences and then aligned onto the non-redundant sequence database. Significant differentially expressed genes were classified within the gene ontology categories. Among them, we recognized genes involved in apoptosis activation, de-activation, and regulation. Conclusions: With the current work, we contributed to the improvement of the first released B. schlosseri genome assembly and offer an overview of the transcriptome changes during the blastogenetic cycle, showing up- and down-regulated genes. These results are important for the comprehension of the events underlying colony growth and regression, cell proliferation, colony homeostasis, and competition among different generations

Reconstructing the galaxy density field with photometric redshifts: II. Environment-dependent galaxy evolution since z≃3z \simeq 3

Although extensively investigated, the role of the environment in galaxy formation is still not well understood. In this context, the Galaxy Stellar Mass Function (GSMF) is a powerful tool to understand how environment relates to galaxy mass assembly and the quenching of star-formation. In this work, we make use of the high-precision photometric redshifts of the UltraVISTA Survey to study the GSMF in different environments up to $z \sim 3$, on physical scales from 0.3 to 2 Mpc, down to masses of $M \sim 10^{10} M_{\odot}$. We witness the appearance of environmental signatures for both quiescent and star-forming galaxies. We find that the shape of the GSMF of quiescent galaxies is different in high- and low-density environments up to $z \sim 2$ with the high-mass end ($M \gtrsim 10^{11} M_{\odot}$) being enhanced in high-density environments. On the contrary, for star-forming galaxies a difference between the GSMF in high- and low density environments is present for masses $M \lesssim 10^{11} M_{\odot}$. Star-forming galaxies in this mass range appear to be more frequent in low-density environments up to $z < 1.5$. Differences in the shape of the GSMF are not visible anymore at $z > 2$. Our results, in terms of general trends in the shape of the GSMF, are in agreement with a scenario in which galaxies are quenched when they enter hot gas-dominated massive haloes which are preferentially in high-density environments.Comment: 18 pages, 10 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Societ

PET/CT incidental detection of second tumor in patients investigated for pancreatic neoplasms

Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up). The finding of an unexpected region of FDG (Fluorodeoxyglucose) uptake can occur when performing whole-body FDG-PET, raising the possibility of a second primary tumor. The aim of this study was to evaluate our experience of second primary cancer incidentally discovered during PET/CT examination performed for pancreatic diseases, during the initial work-up or follow-up after surgical resection

Modeling the surface topography dependence of friction, adhesion, and contact compliance

The small-scale topography of surfaces critically affects the contact area of solids and thus the forces acting between them. Although this has long been known, only recent advances made it possible to reliably model interfacial forces and related quantities for surfaces with multiscale roughness. This article sketches both recent and traditional approaches to their mechanics, while addressing the relevance of nonlinearity and nonlocality arising in soft- and hard-matter contacts

The impact of the COVID-19 pandemic on the psychological health of midwives

Objective. The SARS-CoV-2 pandemic has changed the therapeutic relationship between women and midwives and these changes have been perceived as stressors. The aim of this work is to investigate the effect of these stressors on midwives through an online questionnaire. Materials and Methods. The VRS tool was used, and statistical analysis was performed using Stata. Results. Significant differences were found in the somatization cluster and in subjective stress cluster. Conclusions. The analysis shows that there is a need to implement resilience-enhancing factors such as communication, sharing of distress and the presence of support

Tuning non-linear charge transport between integer and fractional quantum Hall states

Controllable point junctions between different quantum Hall phases are a necessary building block for the development of mesoscopic circuits based on fractionally-charged quasiparticles. We demonstrate how particle-hole duality can be exploited to realize such point-contact junctions. We show an implementation for the case filling factors $\nu=1$ and $\nu^*\le1$ in which both the fractional filling $\nu^*$ and the coupling strength can be finely and independently tuned. A peculiar crossover from insulating to conducting behavior as $\nu^*$ goes from 1/3 to 1 is observed. These results highlight the key role played on inter-edge tunneling by local charge depletion at the point contact.Comment: 4 pages, 3 figures, suppl.ma

Life history and ecological genetics of the colonial ascidian Botryllus schlosseri

The colonial ascidian Botryllus schlosseri is a cosmopolitan, marine filter feeder, introduced as a laboratory research organism in the 1950s. Currently, it is widely used in many laboratories to investigate a variety of biological questions. Recently, it has become a species of concern, as it is an invasive species in many coastal environments. Here, we review studies on the geographical distribution of the species, sexual and asexual reproduction in the field, tolerance to temperature, salinity and anthropogenic activity, polychromatism, enzymatic polymorphism, and the genetic basis of pigmentation. Studying the relationship between genetic polymorphism and the adaptation of B. schlosseri to environmental stress is a challenge of future research and will improve our understanding of its evolutionary success and invasive potential