INDIGENOUS SUSTAINABLE FINANCE AND SUSTAINABLE DEVELOPMENT GOALS: CONTRIBUTIONS FROM REDD+ IN BRAZIL

Indigenous sustainable finance has emerged as a promising research field to understand how indigenous communities can address sustainable governance and economic development issues based on their relationship with the land and cultural aspects. Furthermore, the SDGs have offered a development guide for economies worldwide whilst it pushes forward the applied efforts in pursuing a sustainable future based on its 17 principles. Indigenous territories, in this case, can be understood as an essential asset that can contribute to maintaining biodiversity and remunerating communities for preserving forests, with REDD+ projects constituting a vital initiative to encourage compensation processes for economic activities. This study describes a case of Indigenous Sustainable Finance in Brazil using REDD++ and provides linkages to the Sustainable Development Goals Agenda. Results reveal that new parameters that can contribute to REDD+ processes developed by indigenous communities in Brazil should be set, facilitating the organizational strategy, credit access and territory governance status. Implications for sustainable finance are centred on developing successful constellations of stakeholder action towards social good through green, transitional and heritage bonds

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate mechanisms of glucocorticoid resistance, we determined the prednisolone sensitivity of primary leukemia cells from 444 patients newly diagnosed with ALL and found significantly higher expression of CASP1 (encoding caspase 1) and its activator NLRP3 in glucocorticoid-resistant leukemia cells, resulting from significantly lower somatic methylation of the CASP1 and NLRP3 promoters. Overexpression of CASP1 resulted in cleavage of the glucocorticoid receptor, diminished the glucocorticoid-induced transcriptional response and increased glucocorticoid resistance. Knockdown or inhibition of CASP1 significantly increased glucocorticoid receptor levels and mitigated glucocorticoid resistance in CASP1-overexpressing ALL. Our findings establish a new mechanism by which the NLRP3-CASP1 inflammasome modulates cellular levels of the glucocorticoid receptor and diminishes cell sensitivity to glucocorticoids. The broad impact on the glucocorticoid transcriptional response suggests that this mechanism could also modify glucocorticoid effects in other diseases

Brain-computer interfaces for communication and rehabilitation

Publisher Copyright: © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.Brain-computer interfaces (BCIs) use brain activity to control external devices, thereby enabling severely disabled patients to interact with the environment. A variety of invasive and noninvasive techniques for controlling BCIs have been explored, most notably EEG, and more recently, near-infrared spectroscopy. Assistive BCIs are designed to enable paralyzed patients to communicate or control external robotic devices, such as prosthetics; rehabilitative BCIs are designed to facilitate recovery of neural function. In this Review, we provide an overview of the development of BCIs and the current technology available before discussing experimental and clinical studies of BCIs. We first consider the use of BCIs for communication in patients who are paralyzed, particularly those with locked-in syndrome or complete locked-in syndrome as a result of amyotrophic lateral sclerosis. We then discuss the use of BCIs for motor rehabilitation after severe stroke and spinal cord injury. We also describe the possible neurophysiological and learning mechanisms that underlie the clinical efficacy of BCIs.Peer reviewe

Coherent J/ψ and ψ photoproduction at midrapidity in ultra-peripheral Pb–Pb collisions at √sNN = 5.02 TeV

The coherent photoproduction of J/ψJ/ψ and ψ′ψ′ mesons was measured in ultra-peripheral Pb–Pb collisions at a center-of-mass energy sNN−−−√ = 5.02sNN = 5.02 TeV with the ALICE detector. Charmonia are detected in the central rapidity region for events where the hadronic interactions are strongly suppressed. The J/ψJ/ψ is reconstructed using the dilepton (l+l−l+l−) and proton–antiproton decay channels, while for the ψ′ψ′ the dilepton and the l+l−π+π−l+l−π+π− decay channels are studied. The analysis is based on an event sample corresponding to an integrated luminosity of about 233 μb−1μb−1. The results are compared with theoretical models for coherent J/ψJ/ψ and ψ′ψ′ photoproduction. The coherent cross section is found to be in a good agreement with models incorporating moderate nuclear gluon shadowing of about 0.64 at a Bjorken-x of around 6×10−46×10−4, such as the EPS09 parametrization, however none of the models is able to fully describe the rapidity dependence of the coherent J/ψJ/ψ cross section including ALICE measurements at forward rapidity. The ratio of ψ′ψ′ to J/ψJ/ψ coherent photoproduction cross sections was also measured and found to be consistent with the one for photoproduction off protons

Production of light-flavor hadrons in pp collisions at √s = 7 and √s = 13 TeV

The production of π±, K±, K0S, K∗(892)0, p, ϕ(1020), Λ, Ξ−, Ω−, and their antiparticles was measured in inelastic proton–proton (pp) collisions at a center-of-mass energy of s√ = 13 TeV at midrapidity (|y|<0.5) as a function of transverse momentum (pT) using the ALICE detector at the CERN LHC. Furthermore, the single-particle pT distributions of K0 S, , and in inelastic pp collisions at √s = 7 TeV are reported here for the first time. The pT distributions are studied at midrapidity within the transverse momentum range 0 ≤ pT ≤ 20 GeV/c, depending on the particle species. The pT spectra, integrated yields, and particle yield ratios are discussed as a function of collision energy and compared with measurements at lower √s and with results from various general-purpose QCD-inspired Monte Carlo models. A hardening of the spectra at high pT with increasing collision energy is observed, which is similar for all particle species under study. The transverse mass and xT ≡ 2pT/ √s scaling properties of hadron production are also studied. As the collision energy increases from √s = 7–13 TeV, the yields of non- and single-strange hadrons normalized to the pion yields remain approximately constant as a function of √s, while ratios for multi-strange hadrons indicate enhancements. The pT-differential cross sections of π±, K± and p (p) are compared with next-to-leading order perturbative QCD calculations, which are found to overestimate the cross sections for π± and p (p) at high pT