Linfomas cutáneos con expresión de CD30. Clasificación, pronóstico y terapias dirigidas

La expresión de CD30 en linfocitos tumorales ha cobrado importancia desde la aparición de Brentuximab Vedotin (BV), un fármaco que utiliza este receptor como diana terapéutica y ha demostrado resultados prometedores en muchos pacientes. La expresión de este marcador no es infrecuente en los linfomas cutáneos tanto B como T, y no ha sido por el momento estudiada en profundidad en muchos de ellos. Esta tesis tiene como objetivo revisar aspectos de la clasificación de los linfomas cutáneos, tanto clínica como fenotípica y molecular, centrándonos en algunos cuya expresión de CD30 resulta significativa y poco estudiada hasta la fecha y en los que estas nuevas características fenotípicas y moleculares pueden ser relevantes para una mejor clasificación pronóstica y terapéutica de los pacientes. En el primer trabajo realizamos una revisión general de las alteraciones géneticas, epigenéticas y moleculares más relevantes descritas en procesos linfoproliferativos T CD30 positivos primarios cutáneos hasta la fecha y su posible potencial como dianas terapéuticas. El segundo trabajo identifica características morfológicas e inmunofenotípicas que ayudan a reconocer linfomas anaplásicos con reordenamientos de DUSP-22, identificando como características comunes en éstos la presencia de marcadores T y la ausencia de marcadores citotóxicos y de la vía de JAK/STAT. En el tercer trabajo describimos una serie de 9 pacientes con lesiones linfoproliferativas CD30+ y EBV+ que amplían el espectro clínico-patológico de la úlcera mucocutánea EBV+ (UMC-EBV+).Por último, en el cuarto artículo discutimos las principales características clínicas, histológicas y moleculares de una serie de 13 casos de linfoma B primario cutáneo de la zona marginal (PCMZL) con presencia de más de un 10% de células grandes CD30+ con morfología Hodgkin-like, y analizamos su relación con la progresión clínica e histológica de la enfermedad, así como con otras características inmunofenotípicas. 1. WillemzeR, Cerroni L, Kempf W, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood.2019;133(16):1703-17142. CerroniL. Sin lymphoma: the illustrated guide. In. Foruth ed. The Atrium, Southern Gate, Chchester, West Sussex, PO198SQ,UK: John Wiley & Sins;2014.3. Parrilla Castellar ER, Jaffe ES, Said JW, et al. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous diseaswith widely disparate clinical outcomes. Blood. 2014; 124(9):1473-1480. 4. Swerdlow SH CE, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J. WHO Classiffication of tumoours of haematopoietic and lymphoid tissues. Revised 4th edition ed. Lyon: IARC;2017.5. Mitteldorf C, Kempf W. Cutaneous pseudolymphoma-A review on the spectrum and a proposal for a new classidication. J Cutan Pathol. 20196. Onaindia A, Montes-Moreno S, Rodríguez-Pinilla SM, et al. Primary cutaneous anaplastic large cell lymphomas with 6p25.3 reaarangements exhibit particular histological features. Histopathology. 2015;66(6):846-855.7. Dojcinov SD, Venkataraman G, Raffeld M, Pittaluga S, Jaffe ES. EBV positive mucocutaneous ulcer- a study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol. 2010; 34(3):405-417.8. Servitje O, Gallardo F, Estrach , et al. Primary cutanoeus marginal zone B-cell lympho,a: a clinical, histopathological, immunophenotypic and molecular genetic study of 22 cases. Br J Dermatol. 2002; 147(6): 1147-1158.9. Servitje O, Muniesa C, Benavente Y, et al. Primary cutaneous marginal zone B-cell lymphoma: response to treatment and disease-free survival in a series of 137 patients.J Am Acad Dermatol. 2013; 69(3):357-365.<br /

Impact of Herbicide Treatments on the Construction Materials in the Roman Wall of Lugo, Spain (UNESCO World Heritage Site)

Combined laboratory and field research examining the possible alterations caused by herbicide treatments applied to the construction materials (schist and some granite, bound with mortar) in the Roman wall of Lugo (NW Spain), declared a World Heritage site by UNESCO in 2000, was performed in three separate studies in the past 20 years. In the summers of 1998 and 1999, the herbicides glyphosate, sulphosate and glufosinate–ammonium, as well as physical treatments (infrared and burning) were separately applied to different areas of the wall. In the spring of 2016, the oxyfluorfen herbicide Goal Supreme® was applied to test areas. In the winter of 2018, three essential oils, Origanum vulgare L., Thymus zygis Loefl. ex L., and Thymus vulgaris L., were each applied to test areas. Mineralogical modifications in the materials (determined by X-ray diffraction analysis), as well as visible physical changes, such as colour changes, and the appearance of saline residues were evaluated after the treatments. In the 1998/9 trial, glyphosate and both physical treatments triggered changes in the vermiculite clay minerals in the schists, and the physical treatments also caused changes in the kaolinite. None of the treatments caused highly perceptible colour changes. The oxyfluorfen herbicide did not cause any mineralogical alterations in the construction materials, but it did generate an increase in chloride, nitrate and sulphate contents of the granite and a slight darkening of this material. In the most recent study, the only deleterious effect observed was a perceptible increase in lightness and reduction in the yellow component after the application of Thymus zygis Loefl. ex L. essential oil to graniteThe results of the different studies presented here were financially supported by the following contracts: “Evaluación de diferentes métodos de control de las malas hierbas de la muralla de Lugo. Xunta de Galicia. Consellería de Cultura, Comunicación Social e Turismo. 1998 and 1999”; “Seguimiento de los tratamientos de control de la flora vascular en la muralla romana de Lugo. Restauraciones y Construcciones Luis J. Sánchez SA. 2015–2017”; “Realizar el seguimiento del segundo tratamiento fitosanitario 2017 y realizar un ensayo de herbicidas naturales en las paredes da muralla. Restauraciones y Construcciones Luis J. Sánchez SA. 2017–2018”; “Realizar el seguimiento de la limpieza manual de las paredes de la muralla romana de Lugo en el verano-otoño de 2019 y la aplicación en las paredes de la muralla romana de Lugo de herbicidas naturales potenciales para controlar la germinación de Parietaria Judaica L. Restauraciones y Construcciones Luis J. Sánchez SA. 2019–2020”. The authors are also grateful for financial support from the Xunta de Galicia (grant ED431C 2018/32)S

DUSP22-rearranged anaplastic lymphomas are characterized by specific morphological features and a lack of cytotoxic and JAK/STAT surrogate markers

This work was supported by grants from the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence (MINECO, RTICC ISCIII and CIBERONC) (SAF2013-47416- R, RD06/0020/0107-RD012/0036/0060 and Plan Nacional I+D+I: PI16/01294 and PIE15/0081), AECC and the Madrid Autonomous Community

Propiedades psicométricas de la Escala de Celos patológicos (CECLA): evidencias de validez de constructo en adultos mexicanos y colombianos

Pathological jealousy is a complex emotion and has been considered a potentially violent universal experience. They bring with them negative consequences for the person, the couple, or the rival, even to death. They are associated with anger, sadness, depression, anxiety, doubt, and infidelity. However, in recent reviews, not enough pathological jealousy measurement instruments have been developed to allow the development of new cross-cultural research. This study aimed to collect evidence of the validity of the internal structure both in terms of dimensionality and concurrence, as well as invariance between Mexico (n=257, 70.4% women) and Colombia (n=244, 59.4% women), and reliability of the CECLA scale. Confirmatory Factor Analysis corroborated the internal structure of the three original factors (passionate, obsessive, and delusional jealousy), including evidence of favorable invariance between the Mexican and Colombian samples. In addition, evidence of convergent validity was obtained, and satisfactory internal consistency indices. The results obtained indicated that the CECLA is a useful and recommendable instrument to evaluate pathological jealousy in the Mexican population.Los celos patológicos son una emoción compleja y han sido considerados una experiencia universal potencialmente violenta. Traen consigo consecuencias negativas para la persona, la pareja o el rival, incluso hasta la muerte. Se asocian a la ira, tristeza, depresión, ansiedad, desconfianza e infidelidad. Sin embargo, en revisiones recientes, no han sido desarrollados suficientes instrumentos de medida de los celos patológicos que permitan el desarrollo de nueva investigación transcultural. El objetivo de la investigación fue recolectar evidencia de validez de la estructura interna tanto en términos de dimensionalidad y concurrencia, como de invarianza entre México (n=257, 70.4% mujeres) y Colombia (n=244, 59.4% mujeres), y fiabilidad de la escala CECLA. El Análisis Factorial Confirmatorio corroboró la estructura interna de los tres factores originales (celos pasionales, obsesivos y delirantes), incluida evidencia de favorable invarianza entre las muestras mexicana y colombiana. Además, se obtuvo evidencia de validez convergente, y se lograron adecuados índices de consistencia interna. Los resultados logrados señalaron que el CECLA es un instrumento útil y recomendable para evaluar celos patológicos en la población mexicana

Anuario de estudios celianos 2014-15

La Universidad Camilo José Cela recoge en estos anuarios las investigaciones que se llevan a cabo cada año sobre la obra de quien fue su rector Honorario. Se compromete así, en colaboración con la Fundación que también lleva su nombre, con la herencia literaria y la memoria de CJC, y favorece la divulgación de las conclusiones de los estudios más importantes realizados cada año. El presente número doble (2014-2015) del Anuario de estudios celianos se articula excepcionalmente en dos apartados: ensayos y artículos y los anexos en los que se recogen los textos ganadores del VI y VII Premio de relatos Camilo José Cela para jóvenes. Una revista de vuelo universitario quiere estar también vinculada a la creación literaria que realizan las nuevas generacionesCátedra Camilo José Cela de Estudios Hispánico

The Transiting Multi-planet System HD15337: Two Nearly Equal-mass Planets Straddling the Radius Gap

We report the discovery of a super-Earth and a sub-Neptune transiting the star HD 15337 (TOI-402, TIC 120896927), a bright (V = 9) K1 dwarf observed by the Transiting Exoplanet Survey Satellite (TESS) in Sectors 3 and 4. We combine the TESS photometry with archival High Accuracy Radial velocity Planet Searcher spectra to confirm the planetary nature of the transit signals and derive the masses of the two transiting planets. With an orbital period of 4.8 days, a mass of ${7.51}_{-1.01}^{+1.09}\,{M}_{\oplus }$ and a radius of 1.64 ± 0.06 R ⊕, HD 15337 b joins the growing group of short-period super-Earths known to have a rocky terrestrial composition. The sub-Neptune HD 15337 c has an orbital period of 17.2 days, a mass of ${8.11}_{-1.69}^{+1.82}\,{{\rm{M}}}_{\oplus }$, and a radius of 2.39 ± 0.12 R ⊕, suggesting that the planet might be surrounded by a thick atmospheric envelope. The two planets have similar masses and lie on opposite sides of the radius gap, and are thus an excellent testbed for planet formation and evolution theories. Assuming that HD 15337 c hosts a hydrogen-dominated envelope, we employ a recently developed planet atmospheric evolution algorithm in a Bayesian framework to estimate the history of the high-energy (extreme ultraviolet and X-ray) emission of the host star. We find that at an age of 150 Myr, the star possessed on average between 3.7 and 127 times the high-energy luminosity of the current Sun

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics