Benign fibrous histiocytoma of the brachium in a 14-year-old boy

Fibrous histiocytoma is a benign tumor involving soft tissues that can present as a fibrous mass involving various areas of the human body. Herein, we present a case of benign fibrous histiocytoma in the left brachium in a 14-year-old boy treated with surgical excision

Soft tissue chondromyxoid fibroma.An extremely rare case

Chondromyxoid fibroma is a rare benign bone tumor that accounts for less than 1% of primary bone tumors. The soft tissue variant of this tumor is extremely rare. Herein, we present a case of soft-tissue chondromyxoid fibroma in the foot of a 13-year-old boy treated with surgical excision

A rare case of neglected long-term pathologic fracture of the distal femur due to a giant cell tumor of bone

Giant cell tumor of bone is a histologically benign bone neoplasia that clinically has an aggressive course. In rare cases, it can give "benign" lung metastases or undergo malignant transformation. The World Health Organization defines this neoplasia as an "aggressive, potentially malignant lesion". Herein, we present a rare case of a neglected long-term pathologic fracture of the distal femur in a 20-year-old female patient. After a biopsy, a giant cell tumor of bone was diagnosed. The patient was treated with intralesional curettage, osteoplasty and plate fixation of the fracture. Eight months postoperatively, no local recurrence or metastasis of the tumor was observed

Pelvic pseudotumor following total hip arthroplasty. Case report

According to the literature, the development of metallosis after hip arthroplasty occurs in approximately 5% of patients. Metallic debris in the joint results in massive local and systemic release of cytokines. Excision of the pelvic pseudotumor, as well as revision surgery, is mandatory if there is evidence of osteolysis and loosening of the endoprosthesis. Imaging diagnostics, including magnetic resonance and computed tomography, are crucial for the preoperative planning of surgical intervention

A rare case of Ewing's sarcoma in a 4-year-old child treated by tumor endoprosthetics using 3D printing

Orthopedic oncology surgery often requires, by its very nature, precise and often extensive resections of bone and soft tissue involved in or near the tumor mass. One of the most recent and promising innovations is represented by 3D printing technology, whose main advantage in this field of application is patient specificity, which is essential in an operation that requires high precision and maximum respect for the individuality of his bones and soft tissues. Material and methods: In the present report, we present a 4-year-old boy diagnosed with Ewing's sarcoma involving ¾ of the right tibia. In another medical facility, he was offered amputation. Our team decided to use the "3D printed tumor megaendoprosthesis, double growing, from the Czech company Prospon. For reinsertion of the muscle groups to the endoprosthesis, we used a LARS textile tube that was attached to the femoral and tibial components of the endoprosthesis. A vascular surgeon also participated in the team. The patellar ligament was reinserted to the tibial component, and myoplasty was additionally performed with the medial head of the m. gastrocnemius. Intraoperatively, we lengthened the lower limb by 1.5 cm to delay the upcoming staged lengthening. Results: The postoperative period was uneventful, with sutures removed on the 12th postoperative day. For 3 weeks, a tutor orthosis was placed. Active physiotherapy was started after removal of the orthosis 21 days after surgery. Conclusion: Our goal is to perform a total revision at the end of skeletal growth if possible and replace the current implant with a non-growing tumor megaendoprosthesis in the absence of near or distant metastases and long-term patient survival. Future expectations are that non-invasive lengthening mechanisms or a biological approach will be able to meet the special needs of this population

Comparative electron microscopic and immunohistochemical study of stromal cells in giant cell tumor of bone

Giant cell tumor of bone is an osseous neoplasm that is histologically benign but clinically shows local aggression and high rate of recurrence. The histogenesis of this lesion remains unclear. The histological appearance does not predict the clinical outcome and there are still many unanswered questions with regard to both its treatment and prognosis. In order to further clarify this lesion, we examined ultrastructurally and immunohistochemically the tumor mononuclear cells in ten patients operated on in our hospital for matrix metalloproteinase-9. Positive reaction was detected in the spindle-like stromal cells of giant cell tumor of bone and these cells had the ultrastructural characteristics of fibroblastic cells. The other mononuclear cells did not express matrix metalloproteinase-9 and showed ultrastuctural characteristics of macrophage-like cells. The positive reaction for matrix metalloproteinase-9 in all patients clearly shows that this protease may play a key role in the pathophysiology of giant cell tumor of bone

Association Study between Idiopathic Scoliosis and Polymorphic Variants of VDR, IGF-1, and AMPD1 Genes

Idiopathic scoliosis (IS) is a complex genetic disorder of the musculoskeletal system, characterized by three-dimensional rotation of the spine with unknown etiology. For the aims of the current study we selected 3 single nucleotide polymorphisms with a low incidence of the polymorphic allele in Bulgarian population, AMPD1 (rs17602729), VDR (rs2228670), and IGF-1 (rs5742612), trying to investigate the association between these genetic polymorphisms and susceptibility to and progression of IS. The polymorphic regions of the genes were amplified by polymerase chain reaction (PCR). The PCR products were cleaved with the appropriate restriction enzymes. The statistical analysis was performed by Pearson's chi-squared test. A value of < 0.05 was considered to be statistically significant. In conclusion, this case-control study revealed no statistically significant association between the VDR, IGF-1, and AMPD1 polymorphisms and the susceptibility to IS or curve severity in Bulgarian patients. Replication case-control studies will be needed to examine the association between these candidate-genes and IS in different populations. The identification of molecular markers for IS could be useful for early detection and prognosis of the risk for a rapid progression of the curve. That would permit early stage treatment of the patient with the least invasive procedures

Benign fibrous histiocytoma of the brachium in a 14-year-old boy

Fibrous histiocytoma is a benign tumor involving soft tissues that can present as a fibrous mass involving various areas of the human body. Herein, we present a case of benign fibrous histiocytoma in the left brachium in a 14-year-old boy treated with surgical excision

Soft tissue chondromyxoid fibroma.An extremely rare case

Chondromyxoid fibroma is a rare benign bone tumor that accounts for less than 1% of primary bone tumors. The soft tissue variant of this tumor is extremely rare. Herein, we present a case of soft-tissue chondromyxoid fibroma in the foot of a 13-year-old boy treated with surgical excision

Rare form of intramedullary osteosclerosis in the tibia

The intramedullary osteosclerosis (IMOS) is a rare condition with no specific radiographic features - except the increased bone formation, which is no due to heredity, infection, acute trauma or system disorders such as skeletal dysplasia. IMOS   is usually diagnosed randomly - after imiging study of the affected leg - which usually has pain that  intensifies with physical activity. The laboratory findings are typically normal. Intramedullary osteosclerosis may affect a single or multiple bones without clear periosteal reaction, soft-tissue swelling, nor nidus. For being a rare condition and because of the lack of certain specific features the intramedullary osteosclerosis is still not well understood. This is why the diagnostic process is difficult and usually comes with delay. A 14-years-old patient active athlete is admitted in the clinic with complains of mild, intermittent pain in the right thigh, aggravating with physical activity. The symptoms first appear 3 months ago , with no trauma or other conditions presented. Clinical examination revealed palpable discrete swelling of the soft tissues. After series of radiographs, CT and MRI of the left thigh - a not-well-defined, localized periosteal reaction is noted and almost full oblitaration of the intramedullary canal of the right tibia in its proximal third