A thymine functionalized molecular motor

De begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie. The supervisor and/or the author did not authorize public publication of the thesis.

Pretoriana, no. 066 & 067, Aug-Dec 1971

Haak & Zoon -- Oud-rugbyspringbokke na wie name van strate en lane in Danville-uitbreiding no. 1 in Pretoria vernoem is / G.J. van Eck -- Die ou begraafplaas / A.S. Malherbe -- Rente op trane / Aletta Lubbe -- Aandeelhouers van die Pretoria Oost-Einde Skool Vereniging Beperkt" / Jan Ploeger -- Correspondence -- Old Pretoria Society annual report 1970 / N.L.P. van der Walt -- Ledelys = List of member

Stratigraphy and Geochemistry of the Vossenveld Formation

The Winterswijkse Steengroeve quarry complex in the east of the Netherlands exposes a ~ 40 m thick sedimentary sequence of intertidal and shallow marine deposits of the Vossenveld Formation dated as Anisian (early Middle Triassic). Here, we present a detailed stratigraphic and sedimentological description combined with geochemical data (carbonate content, spectral gamma ray, magnetic susceptibility, stable isotopes) of the sedimentary sequence in the Winterswijkse Steengroeve. Stable isotope ratios point to paleotemperatures in the range of 25 to 35 °C. These high temperatures in combination with the shallow enclosed character and proximity to the equator made the environment particularly susceptible to substantial evaporation and likely very saline. The concentration of predominantly isolated skeletal fossils resulted from storm activity. Unexpected is the overall increasing salinity in combination with the occurrence of larger sauropterygians in the top 10 m, accompanied by the halophytic bivalve Neoschizodus orbicularis. A subsequent literature study of the distribution of the sauropterygian genera described from the Vossenveld Formation sheds light on their deposition and burial conditions. The combined isotopic, geochemical, and sedimentological study on the Vossenveld Formation elucidates the depositional environment in which the rich fossil assemblage of Winterswijk is preserved. The obtained information on the preservation and paleoenvironment is pivotal in understanding the mode and pacing of the biotic recovery after the end-Permian mass extinction

Stratigraphy and Geochemistry of the Vossenveld Formation

The Winterswijkse Steengroeve quarry complex in the east of the Netherlands exposes a ~ 40 m thick sedimentary sequence of intertidal and shallow marine deposits of the Vossenveld Formation dated as Anisian (early Middle Triassic). Here, we present a detailed stratigraphic and sedimentological description combined with geochemical data (carbonate content, spectral gamma ray, magnetic susceptibility, stable isotopes) of the sedimentary sequence in the Winterswijkse Steengroeve. Stable isotope ratios point to paleotemperatures in the range of 25 to 35 °C. These high temperatures in combination with the shallow enclosed character and proximity to the equator made the environment particularly susceptible to substantial evaporation and likely very saline. The concentration of predominantly isolated skeletal fossils resulted from storm activity. Unexpected is the overall increasing salinity in combination with the occurrence of larger sauropterygians in the top 10 m, accompanied by the halophytic bivalve Neoschizodus orbicularis. A subsequent literature study of the distribution of the sauropterygian genera described from the Vossenveld Formation sheds light on their deposition and burial conditions. The combined isotopic, geochemical, and sedimentological study on the Vossenveld Formation elucidates the depositional environment in which the rich fossil assemblage of Winterswijk is preserved. The obtained information on the preservation and paleoenvironment is pivotal in understanding the mode and pacing of the biotic recovery after the end-Permian mass extinction

Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

Parkinson’s disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation. We use Mendelian randomization to investigate over 3,000 genes that encode druggable proteins and predict their efficacy as drug targets for Parkinson’s disease. We use expression and protein quantitative trait loci to mimic exposure to medications, and we examine the causal effect on Parkinson’s disease risk (in two large cohorts), age at onset and progression. We propose 23 drug-targeting mechanisms for Parkinson’s disease, including four possible drug repurposing opportunities and two drugs which may increase Parkinson’s disease risk. Of these, we put forward six drug targets with the strongest Mendelian randomization evidence. There is remarkably little overlap between our drug targets to reduce Parkinson’s disease risk versus progression, suggesting different molecular mechanisms. Drugs with genetic support are considerably more likely to succeed in clinical trials, and we provide compelling genetic evidence and an analysis pipeline to prioritise Parkinson’s disease drug development