Experimental Observation of Large Chern numbers in Photonic Crystals

Despite great interest in the quantum anomalous Hall phase and its analogs, all experimental studies in electronic and bosonic systems have been limited to a Chern number of one. Here, we perform microwave transmission measurements in the bulk and at the edge of ferrimagnetic photonic crystals. Bandgaps with large Chern numbers of 2, 3, and 4 are present in the experimental results which show excellent agreement with theory. We measure the mode profiles and Fourier transform them to produce dispersion relations of the edge modes, whose number and direction match our Chern number calculations.Comment: This experimental work was accepted to PRL on Oct. 13, 2015. Our theoretical work from PRL http://dx.doi.org/10.1103/PhysRevLett.113.11390

Nodal-link semimetals

In topological semimetals, the valence band and conduction band meet at zero-dimensional nodal points or one-dimensional nodal rings, which are protected by band topology and symmetries. In this Rapid Communication, we introduce "nodal-link semimetals", which host linked nodal rings in the Brillouin zone. We put forward a general recipe based on the Hopf map for constructing models of nodal-link semimetal. The consequences of nodal ring linking in the Landau levels and Floquet properties are investigated.Comment: 12 pages, 5 figures, including supplemental material. Published versio

Diagnostic Accuracy of CEUS LI-RADS for the Characterization of Liver Nodules 20 mm or Smaller in Patients at Risk for Hepatocellular Carcinoma.

Background: American College of Radiology contrast agent–enhanced US Liver Imaging Reporting and Data System (CEUS LI-RADS) was developed to improve the accuracy of hepatocellular carcinoma (HCC) diagnosis at contrast agent2enhanced US. However, to the knowledge of the authors, the diagnostic accuracy of the system in characterization of liver nodules 20 mm or smaller has not been fully evaluated. Purpose: To evaluate the diagnostic accuracy of CEUS LI-RADS in diagnosing HCC in liver nodules 20 mm or smaller in patients at risk for HCC. Materials and Methods: Between January 2015 and February 2018, consecutive patients at risk for HCC presenting with untreated liver nodules 20 mm or less were enrolled in this retrospective double-reader study. Each nodule was categorized according to the CEUS LI-RADS and World Federation for Ultrasound in Medicine and Biology (WFUMB)–European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) criteria. Diagnostic performance of CEUS LI-RADS and WFUMB-EFSUMB characterization was evaluated by using tissue histologic analysis, multiphase contrast-enhanced CT and MRI, and imaging follow-up as reference standard and compared by using McNemar test. Results: The study included 175 nodules (mean diameter, 16.1 mm 6 3.4) in 172 patients (mean age, 51.8 years 6 10.6; 136 men). The sensitivity of CEUS LR-5 versus WFUMB-EFSUMB criteria in diagnosing HCC was 73.3% (95% confidence inter-val [CI]: 63.8%, 81.5%) versus 88.6% (95% CI: 80.9%, 94%), respectively (P, .001). The specificity of CEUS LR-5 versus WFUMB-EFSUMB criteria was 97.1% (95% CI: 90.1%, 99.7%) versus 87.1% (95% CI: 77%, 94%), respectively (P = .02). No malignant lesions were found in CEUS LR-1 and LR-2 categories. Only two nodules (of 41; 5%, both HCC) were malignant in CEUS LR-3 category. The incidences of HCC in CEUS LR-4, LR-5, and LR-M were 48% (11 of 23), 98% (77 of 79), and 75% (15 of 20), respectively. Two of 175 (1.1%) histologic analysis2confirmed intrahepatic cholangiocarcinomas were categorized as CEUS LR-M by CEUS LI-RADS and misdiagnosed as HCC by WFUMB-EFSUMB criteria. Conclusion: The contrast-enhanced US Liver Imaging Reporting and Data System (CEUS LI-RADS) algorithm was an effective tool for characterization of small (≤20 mm) liver nodules in patients at risk for hepatocellular carcinoma (HCC). Compared with World Federation for Ultrasound in Medicine and Biology2European Federation of Societies for Ultrasound in Medicine and Biology criteria, CEUS LR-5 demonstrated higher specificity for diagnosing small HCCs with lower sensitivity

2-(1-Ethyl-5-meth­oxy-1H-indol-3-yl)-N-(4-meth­oxy­phen­yl)-2-oxoacetamide

The title compound, C20H20N2O4, crystallizes with four independent mol­ecules in the asymmetric unit. In the mol­ecules, the dihedral angles between the benzene rings and indole mean planes are 24.5 (1), 22.5 (1), 8.8 (1) and 13.9 (1)°. In the crystal, inter­molecular N—H⋯O hydrogen bonds are present between the imino groups and the adjacent carbonyl groups. π–π stacking is also observed with a centroid–centroid distance between nearly parallel pyrrole rings of 3.745 (3) Å

An Overview of Systematic Reviews of Shenmai Injection for Healthcare

Shenmai injection (SMI) is widely applied in clinical practice as an organ protector. This overview is to evaluate the current evidence from systematic reviews (SRs) of SMI for healthcare. The literature searches were carried out in 6 databases without language restrictions until December 2012. The quality of the primary studies from the respective SRs was evaluated by using Jadad score. The overview quality assessment questionnaire (OQAQ) was used to evaluate the methodological quality of all included SRs. Twenty eligible SRs were identified. They reported a wide range of conditions, including SMI for cardio/cerebrovascular diseases, viral myocarditis, tumor chemotherapy, and adverse drug reactions. Most of the primary studies were of good quality only in 1 SR of non-small-cell lung cancer. According to the OQAQ scores, the quality of included SRs was variable and six reviews were of high quality with a score of 5 points. Two SRs showed that SMI had low adverse drug reaction occurrence. In conclusion, there is mixed evidence to support efficacy of SMI for an adjunct therapy to tumor chemotherapy and premature evidence for the use of SMI for cardio/cerebrovascular disorders and viral myocarditis. SMI seems generally safe for clinical application. Further large sample-size and well-designed RCTs are needed

Classical-driving-assisted quantum synchronization in non-Markovian environments

We study the quantum phase synchronization of a driven two-level system (TLS) coupled to a structured environment and demonstrate that quantum synchronization can be enhanced by the classical driving field. We use the Husimi $Q$-function to characterize the phase preference and find the in-phase and anti-phase locking phenomenon in the phase diagram. Remarkably, we show that the classical driving enables a TLS to reach stable anti-phase locking in the Markovian regime. However, we find that the synergistic action of classical driving and non-Markovian effects significantly enhances the in-phase locking. By introducing the $S$-function and its maximal value to quantify the strength of synchronization and sketch the synchronization regions, we observe the typical signatures of the hollowed Arnold tongue in the parameter regions of synchronization. In the hollowed Arnold tongue, the synchronization regions exist both inside and outside the tongue while unsynchronized regions only lie on the boundary line. We also provide an intuitive interpretation of the above results by using the quasimode theory.Comment: 10 pages, 5 figures, revised versio