26 research outputs found
Topological Atomic Spinwave Lattices by Dissipative Couplings
Recent experimental advance in creating dissipative couplings provides a new
route for engineering exotic lattice systems and exploring topological
dissipation. Using the spatial lattice of atomic spinwaves in a vacuum vapor
cell, where purely dissipative couplings arise from diffusion of atoms, we
experimentally realize a dissipative version of the Su-Schrieffer-Heeger (SSH)
model. We construct the dissipation spectra of the topological or trivial
lattices via electromagnetically-induced-transparency (EIT) spectroscopy. The
topological dissipation spectrum is found to exhibit edge modes at dissipation
rates within a dissipative gap, decoupled from the bulk. We also validate
chiral symmetry of the dissipative SSH couplings. This work paves the way for
realizing topology-enabled quantum correlations and non-Hermitian topological
quantum optics via dissipative couplings.Comment: 5 pages, 4 figure
No Provisioned Concurrency: Fast RDMA-codesigned Remote Fork for Serverless Computing
Serverless platforms essentially face a tradeoff between container startup
time and provisioned concurrency (i.e., cached instances), which is further
exaggerated by the frequent need for remote container initialization. This
paper presents MITOSIS, an operating system primitive that provides fast remote
fork, which exploits a deep codesign of the OS kernel with RDMA. By leveraging
the fast remote read capability of RDMA and partial state transfer across
serverless containers, MITOSIS bridges the performance gap between local and
remote container initialization. MITOSIS is the first to fork over 10,000 new
containers from one instance across multiple machines within a second, while
allowing the new containers to efficiently transfer the pre-materialized states
of the forked one. We have implemented MITOSIS on Linux and integrated it with
FN, a popular serverless platform. Under load spikes in real-world serverless
workloads, MITOSIS reduces the function tail latency by 89% with orders of
magnitude lower memory usage. For serverless workflow that requires state
transfer, MITOSIS improves its execution time by 86%.Comment: To appear in OSDI'2
Resveratrol Attenuated Low Ambient Temperature-Induced Myocardial Hypertrophy via Inhibiting Cardiomyocyte Apoptosis
Transient overexpression of TGFBR3 induces apoptosis in human nasopharyngeal carcinoma CNE-2Z cells
Effect of Yoga Intervention on Problem Behavior and Motor Coordination in Children with Autism
Children with autism exhibit more pronounced symptoms of both problem behaviors and motor coordination difficulties. Yoga, recognized as an effective intervention modality, can be valuable after assessing its efficacy in addressing problem behaviors and motor coordination challenges, ultimately contributing to symptom alleviation in autism. The randomized controlled trial (RCT) was used to divide 17 children with autism into an intervention group (n = 9) and a control group (n = 8). The intervention group participated in an 8-week yoga intervention training (three sessions/week, 45–50 min/session), and the control group did not participate in yoga training but only in daily program activities. Pre-test, mid-test, post-test, and after delayed test, teachers assessed the effect of yoga intervention on problem behaviors of children with autism through the Aberrant Behavior Checklist (ABC) and the effect of yoga intervention on motor coordination through the Movement Assessment Battery for Children—Second Edition (MABC2). Results show that the yoga intervention is effective in reducing problem behaviors and improving motor coordination in children with autism. Yoga intervention significantly reduces irritability and social withdrawal in children with autism. Yoga intervention had the most significant improvement in ball skills and static and dynamic balance
Development and validation of a predictive model for the prognosis in aneurysmal subarachnoid hemorrhage
Rab3a attenuates spinal cord injury by mediating vesicle release
Background: Rab3a regulates vesicle secretion and transport. Emerging evidences have shown that extracellular vesicles (EVs) can reach target lesions of injured spinal cords and exert a positive effect on these lesions. However, the molecular mechanism by which Rab3a regulates vesicle secretion to ameliorate spinal cord injury (SCI) is not fully understood. Methods: An SCI rat model was established which was used to examine the pathological changes and Rab3a expression in spinal cord tissue. Rab3a was overexpressed in the model rats to demonstrate its effect on SCI repair. Rab3a was also knocked down in neuronal cells to verify its role in vesicle secretion and neuronal cells. The binding protein of Rab3a was identified by Co-IP and mass spectrometry. Results: Rab3a was significantly downregulated in SCI rats and Rab3a overexpression promoted SCI repair. Rab3a knockdown inhibited the secretion of neuronal cell-derived EVs. Compared to the EVs from the equal number of control neuronal cells, EVs from Rab3a-knockdown neuronal cells promoted M1 macrophage polarization, which in turn, promoted neuronal cell apoptosis. Mechanistically, STXBP1 was identified as a binding protein of Rab3a, and their interaction promoted the secretion of neuronal cell-derived EVs. Furthermore, METTL2b was significantly downregulated in SCI rats, and METTL2b knockdown significantly reduced Rab3a protein expression. Conclusion: These results suggest that Rab3a promotes the secretion of neuronal cell-derived EVs by interacting with its binding protein STXBP1. Neuronal cells-derived EVs inhibited the polarization of M1 macrophages in the spinal cord microenvironment, thereby promoting SCI repair. Our findings provide a theoretical basis for the clinical treatment of SCI