907 research outputs found
Queensland University of Technology at TREC 2005
The Information Retrieval and Web Intelligence (IR-WI) research group is a research team at the Faculty of Information Technology, QUT, Brisbane, Australia. The IR-WI group participated in the Terabyte and Robust track at TREC 2005, both for the first time. For the Robust track we applied our existing information retrieval system that was originally designed for use with structured (XML) retrieval to the domain of document retrieval. For the Terabyte track we experimented with an open source IR system, Zettair and performed two types of experiments. First, we compared Zettair’s performance on both a high-powered supercomputer and a distributed system across seven midrange personal computers. Second, we compared Zettair’s performance when a standard TREC title is used, compared with a natural language query, and a query expanded with synonyms. We compare the systems both in terms of efficiency and retrieval performance. Our results indicate that the distributed system is faster than the supercomputer, while slightly decreasing retrieval performance, and that natural language queries also slightly decrease retrieval performance, while our query expansion technique significantly decreased performance
On two-variable guarded fragment logic with expressive local Presburger constraints
We consider the extension of two-variable guarded fragment logic with local
Presburger quantifiers. These are quantifiers that can express properties such
as ``the number of incoming blue edges plus twice the number of outgoing red
edges is at most three times the number of incoming green edges'' and captures
various description logics with counting, but without constant symbols. We show
that the satisfiability of this logic is EXP-complete. While the lower bound
already holds for the standard two-variable guarded fragment logic, the upper
bound is established by a novel, yet simple deterministic graph theoretic based
algorithm
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
AbstractEGF receptor (EGFR) overexpression correlates with metastasis in a variety of carcinomas, but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted cell-cell adhesion and caused epithelial-to-mesenchymal transition (EMT) in human tumor cells overexpressing EGFR, and also induced caveolin-dependent endocytosis of E-cadherin, a cell-cell adhesion protein. Chronic EGF treatment resulted in transcriptional downregulation of caveolin-1 and induction of the transcriptional repressor Snail, correlating with downregulation of E-cadherin expression. Caveolin-1 downregulation enhanced β-catenin-TCF/LEF-1 transcriptional activity in a GSK-3β-independent manner. Antisense RNA-mediated reduction of caveolin-1 expression in EGFR-overexpressing tumor cells recapitulated these EGF-induced effects and enhanced invasion into collagen gels. We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis
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Reducing defects through organizational learning within a Housing Association environment
Housing Associations (HAs) contribute circa 20% of the UK’s housing supply. HAs are however under increasing pressure as a result of funding cuts and rent reductions. Due to the increased pressure, a number of processes are currently being reviewed by HAs, especially how they manage and learn from defects. Learning from defects is considered a useful approach to achieving defect reduction within the UK housebuilding industry. This paper contributes to our understanding of how HAs learn from defects by undertaking an initial round table discussion with key HA stakeholders as part of an ongoing collaborative research project with the National House Building Council (NHBC) to better understand how house builders and HAs learn from defects to reduce their prevalence. The initial discussion shows that defect information runs through a number of groups, both internal and external of a HA during both the defects management process and organizational learning (OL) process. Furthermore, HAs are reliant on capturing and recording defect data as the foundation for the OL process. During the OL process defect data analysis is the primary enabler to recognizing a need for a change to organizational routines. When a need for change has been recognized, new options are typically pursued to design out defects via updates to a HAs Employer’s Requirements. Proposed solutions are selected by a review board and committed to organizational routine. After implementing a change, both structured and unstructured feedback is sought to establish the change’s success. The findings from the HA discussion demonstrates that OL can achieve defect reduction within the house building sector in the UK. The paper concludes by outlining a potential ‘learning from defects model’ for the housebuilding industry as well as describing future work
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Detecting defects in the UK new-build housing sector: a learning perspective
Rapid growth in the production of new homes in the UK is putting build quality under pressure as evidenced by an increase in the number of defects. Housing associations (HAs) contribute approximately 20% of the UK’s new housing supply. HAs are currently experiencing central government funding cuts and rental revenue reductions. As part of HAs’ quest to ramp up supply despite tight budget conditions, they are reviewing how they learn from defects. Learning from defects is argued as a means of reducing the persistent defect problem within the UK housebuilding industry, yet how HAs learn from defects is under-researched. The aim of this research is to better understand how HAs, in practice, learn from past defects to reduce the prevalence of defects in future new homes. The theoretical lens for this research is organizational learning. The results drawn from 12 HA case studies indicate that effective organizational learning has the potential to reduce defects within the housing sector. The results further identify that HAs are restricting their learning to focus primarily on reducing defects through product and system adaptations. Focusing on product and system adaptations alone suppresses HAs’ abilities to reduce defects in the future
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