907 research outputs found

    Queensland University of Technology at TREC 2005

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    The Information Retrieval and Web Intelligence (IR-WI) research group is a research team at the Faculty of Information Technology, QUT, Brisbane, Australia. The IR-WI group participated in the Terabyte and Robust track at TREC 2005, both for the first time. For the Robust track we applied our existing information retrieval system that was originally designed for use with structured (XML) retrieval to the domain of document retrieval. For the Terabyte track we experimented with an open source IR system, Zettair and performed two types of experiments. First, we compared Zettair’s performance on both a high-powered supercomputer and a distributed system across seven midrange personal computers. Second, we compared Zettair’s performance when a standard TREC title is used, compared with a natural language query, and a query expanded with synonyms. We compare the systems both in terms of efficiency and retrieval performance. Our results indicate that the distributed system is faster than the supercomputer, while slightly decreasing retrieval performance, and that natural language queries also slightly decrease retrieval performance, while our query expansion technique significantly decreased performance

    Student Recital: Tony Lu, Tenor

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    On two-variable guarded fragment logic with expressive local Presburger constraints

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    We consider the extension of two-variable guarded fragment logic with local Presburger quantifiers. These are quantifiers that can express properties such as ``the number of incoming blue edges plus twice the number of outgoing red edges is at most three times the number of incoming green edges'' and captures various description logics with counting, but without constant symbols. We show that the satisfiability of this logic is EXP-complete. While the lower bound already holds for the standard two-variable guarded fragment logic, the upper bound is established by a novel, yet simple deterministic graph theoretic based algorithm

    Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion

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    AbstractEGF receptor (EGFR) overexpression correlates with metastasis in a variety of carcinomas, but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted cell-cell adhesion and caused epithelial-to-mesenchymal transition (EMT) in human tumor cells overexpressing EGFR, and also induced caveolin-dependent endocytosis of E-cadherin, a cell-cell adhesion protein. Chronic EGF treatment resulted in transcriptional downregulation of caveolin-1 and induction of the transcriptional repressor Snail, correlating with downregulation of E-cadherin expression. Caveolin-1 downregulation enhanced β-catenin-TCF/LEF-1 transcriptional activity in a GSK-3β-independent manner. Antisense RNA-mediated reduction of caveolin-1 expression in EGFR-overexpressing tumor cells recapitulated these EGF-induced effects and enhanced invasion into collagen gels. We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis
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