Optical studies of transparent ferroelectric strontium-barium niobate/silica nanocomposite

Author name used in this publication: C. L. MakAuthor name used in this publication: K. H. Wong2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Photoluminescence of transparent strontium–barium–niobate-doped silica nanocomposites

Author name used in this publication: C. L. MakAuthor name used in this publication: K. H. Wong2001-2002 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Effects of postdeposition annealing on the dielectric properties of antiferroelectric lanthanum-doped lead zirconate stannate titanate thin films derived from pulsed laser deposition

Author name used in this publication: K. H. Wong2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

High tunability in compositionally graded epitaxial barium strontium titanate thin films by pulsed-laser deposition

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Spontaneous recovery of hydrogen-degraded TiO₂ ceramic capacitors

2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Effect of dc bias on the Curie-Weiss exponent in 0.76Pb(Mg[sub ⅓]Nb[sub ⅔]) O₃-0.24PbTiO₃ ferroelectric single crystal

2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Causes of industrial protein a column degradation, explored using Raman spectroscopy.

Monoclonal antibodies (mAbs) are used extensively as biotherapeutics for chronic and acute conditions. Production of mAbs is lengthy and expensive, with protein A affinity capture the most costly step, due both to the nature of the resin and its marked reduction in binding capacity with repeated use. Our previous studies using in situ ATR-FTIR spectroscopy indicated that loss in protein A binding capacity is not the result of leaching or degradation of protein A ligand, suggesting fouling is the principal cause. Here we explore binding behavior and resin capacity loss using Raman spectroscopy. Our data reveal a distinct Raman spectral fingerprint for mAb bound to the protein A ligand of MabSelect SuRe. The results show that the drop in static binding capacity (SBC) previously observed for used protein A resin is discernible by Raman spectroscopy in combination with partial least-squares regression. The SBC is lowest (35.76 mg mL-1) for used inlet resin compared to used outlet (40.17 mg mL-1) and unused resin samples (70.35 mg mL-1). Depth profiling by Raman spectroscopy indicates that at below saturating concentrations (∼18 mg mL-1), binding of mAb is not homogeneous through used resin beads with protein binding preferentially to the outer regions of the bead, in contrast to fully homogeneous distribution through unused control MabSelect SuRe resin beads. Analysis of the Raman spectra indicates that one foulant is irreversibly bound mAb. The presence of irreversibly bound mAb and host cell proteins was confirmed by mass spectrometric analysis of used resin beads

Role of oxygen pressure during pulsed laser deposition on the electrical and dielectric properties of antiferroelectric lanthanum-doped lead zirconate stannate titanate thin films

Author name used in this publication: K. H. Wong2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Enhanced magnetoelectric effect in Terfenol-D and flextensional cymbal laminates

Author name used in this publication: S. W. Or2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe