63 research outputs found

    Rethinking pulmonary toxicity in advanced non-small cell lung cancer in the era of combining anti-PD-1/PD-L1 therapy with thoracic radiotherapy.

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    The combination of programmed cell death 1/programmed cell death ligand 1 blockade and thoracic radiotherapy has become the new standard of care in the treatment of locally advanced non-small-cell lung cancer. The information regarding the pulmonary safety of such therapy remains limited to mostly retrospective studies and case reports with a small portion of data from prospective clinical trials. By analyzing the underlying mechanisms of interactions between radiation and immunotherapy from preclinical data and summarizing safety data from relevant clinical studies with pulmonary toxicity, we believe that longer and rigorous follow-up is warranted, to determine if the combination of such modalities is appropriate for patients without risking undue toxicity

    Coupled flow accumulation and atmospheric blocking govern flood duration

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    We present a physically based Bayesian network model for inference and prediction of flood duration that allows for a deeper understanding of the nexus of antecedent flow regime, atmospheric blocking, and moisture transport/release mechanisms. Distinct scaling factors at the land surface and regional atmospheric levels are unraveled using this Bayesian network model. Land surface scaling explains the variability in flood duration as a function of cumulative exceedance index, a new measure that represents the evolution of the flood in the basin. Dynamic atmospheric scaling explains the cumulative exceedance index using the interaction between atmospheric blocking system and the synergistic model of wind divergence and atmospheric water vapor. Our findings underline that the synergy between a large persistent low-pressure blocking system and a higher rate of divergent wind often triggers a long-duration flood, even in the presence of moderate moisture supply in the atmosphere. This condition in turn causes an extremely long-duration flood if the basin-wide cumulative flow prior to the flood event was already high. Thus, this new land-atmospheric interaction framework integrates regional flood duration scaling and dynamic atmospheric scaling to enable the coupling of ‘horizontal’ (for example, streamflow accumulation inside the basin) and ‘vertical’ flow of information (for example, interrelated land and ocean-atmosphere interactions), providing an improved understanding of the critical forcing of regional hydroclimatic systems. This Bayesian model approach is applied to the Missouri River Basin, which has the largest system of reservoirs in the United States. Our predictive model can aid in decision support systems for the protection of national infrastructure against long-duration flood events.info:eu-repo/semantics/publishedVersio

    Future Atmospheric Rivers and Impacts on Precipitation: Overview of the ARTMIP Tier 2 High‐Resolution Global Warming Experiment

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    Atmospheric rivers (ARs) are long, narrow synoptic scale weather features important for Earth’s hydrological cycle typically transporting water vapor poleward, delivering precipitation important for local climates. Understanding ARs in a warming climate is problematic because the AR response to climate change is tied to how the feature is defined. The Atmospheric River Tracking Method Intercomparison Project (ARTMIP) provides insights into this problem by comparing 16 atmospheric river detection tools (ARDTs) to a common data set consisting of high resolution climate change simulations from a global atmospheric general circulation model. ARDTs mostly show increases in frequency and intensity, but the scale of the response is largely dependent on algorithmic criteria. Across ARDTs, bulk characteristics suggest intensity and spatial footprint are inversely correlated, and most focus regions experience increases in precipitation volume coming from extreme ARs. The spread of the AR precipitation response under climate change is large and dependent on ARDT selection

    Diagnosis of the Tropical Moisture Exports to the Mid-Latitudes and the Role of Atmospheric Steering in the Extreme Precipitation

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    Three river basins, i.e., the Yangtze river, the Mississippi river and the Loire river, were presented as case studies to explore the association among atmospheric circulations, moisture exports and extreme precipitations in the mid-latitudes. The major moisture source regions in the tropics for the three river basins are first identified using the Tropical Moisture Exports (TMEs) dataset. The space-time characteristics of their respective moisture sources are presented. Then, the trajectory curve clustering analysis is applied to the TMEs tracks originating from the identified source regions during each basin’s peak TMEs activity and flood seasons. Our results show that the moisture tracks for each basin can be categorized into 3 or 4 clusters with distinct spatial trajectory features. Our further analysis on these clustered trajectories reveals that the contributions of moisture release from different clusters are associated with their trajectory features and travel speeds. In order to understand the role of associated atmospheric steering, daily composites of the geopotential heights anomalies and the vertical integral of moisture flux anomalies from 7 days ahead to the extreme precipitation days (top 5%) are examined. The evolutions of the atmospheric circulation patterns and the moisture fluxes are both consistent with the TMEs tracks that contribute more moisture releases to the study regions. The findings imply that atmospheric steering plays an important role in the moisture transport and release, especially for the extreme precipitations. We also find that the association between TMEs moisture release and precipitation is nonlinear. The extreme precipitation is associated with high TMEs moisture release for all of the three study regions

    Asia Faces a Growing Threat From Intraseasonal Compound Weather Whiplash

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    Abstract The sudden swings between drought/heat and pluvial could cause adverse impacts far surpassing the sum of their individual effect. We propose a concept of intraseasonal “compound whiplash event” (CWE) to investigate sudden swings between wet and the compounding warm‐dry events and their changes under climate change. We find that global warming would likely escalate the compound whiplash frequency to two to three and half times (two to three times) by the end of the 21st century under the business‐as‐usual scenario (mitigated scenario). The growing threat of CWE not only stems from the increasing occurrence but also from its intensified severity and extended spatial coverage. Among all sub‐regions, East Asian summer monsoon (EASM) region would expect the largest intensification. The resulting population exposure would soar two‐to‐three‐fold over Asia. Populous regions such as North India and EASM region might face a much worse situation than the western China where population is sparse and projected to decline. Moreover, the seasonality of swings with opposite directions would further split as a response to the skewed Asian monsoon annual cycle, leading to more frequent heat‐drought to pluvial swings in spring, and more opposite‐direction swings in autumn, disrupting cultivation and water management convention
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