3,392 research outputs found
Governing Behavioral Relationships in Megaprojects: Examining Effect of Three Governance Mechanisms under Project Uncertainties
AgentTuning: Enabling Generalized Agent Abilities for LLMs
Open large language models (LLMs) with great performance in various tasks
have significantly advanced the development of LLMs. However, they are far
inferior to commercial models such as ChatGPT and GPT-4 when acting as agents
to tackle complex tasks in the real world. These agent tasks employ LLMs as the
central controller responsible for planning, memorization, and tool
utilization, necessitating both fine-grained prompting methods and robust LLMs
to achieve satisfactory performance. Though many prompting methods have been
proposed to complete particular agent tasks, there is lack of research focusing
on improving the agent capabilities of LLMs themselves without compromising
their general abilities. In this work, we present AgentTuning, a simple and
general method to enhance the agent abilities of LLMs while maintaining their
general LLM capabilities. We construct AgentInstruct, a lightweight
instruction-tuning dataset containing high-quality interaction trajectories. We
employ a hybrid instruction-tuning strategy by combining AgentInstruct with
open-source instructions from general domains. AgentTuning is used to
instruction-tune the Llama 2 series, resulting in AgentLM. Our evaluations show
that AgentTuning enables LLMs' agent capabilities without compromising general
abilities. The AgentLM-70B is comparable to GPT-3.5-turbo on unseen agent
tasks, demonstrating generalized agent capabilities. We open source the
AgentInstruct and AgentLM-7B, 13B, and 70B models at
https://github.com/THUDM/AgentTuning, serving open and powerful alternatives to
commercial LLMs for agent tasks.Comment: 31 page
Expanded CURB-65: A new score system predicts severity of community-acquired pneumonia with superior efficiency
Aim of this study was to develop a new simpler and more effective severity score for communityacquired pneumonia (CAP) patients. A total of 1640 consecutive hospitalized CAP patients in Second
Affiliated Hospital of Zhejiang University were included. The effectiveness of different pneumonia
severity scores to predict mortality was compared, and the performance of the new score was validated
on an external cohort of 1164 patients with pneumonia admitted to a teaching hospital in Italy.
Using ageā„ā65 years, LDH>230u/L, albumin<3.5g/dL, platelet count<100Ć109/L, confusion,
urea>7mmol/L, respiratory rateā„30/min, low blood pressure, we assembled a new severity score
named as expanded-CURB-65. The 30-day mortality and length of stay were increased along with
increased risk score. The AUCs in the prediction of 30-day mortality in the main cohort were 0.826
(95%CI, 0.807ā0.844), 0.801 (95%CI, 0.781ā0.820), 0.756 (95%CI, 0.735ā0.777), 0.793 (95%CI,
0.773ā0.813) and 0.759 (95%CI, 0.737ā0.779) for the expanded-CURB-65, PSI, CURB-65, SMART-COP
and A-DROP, respectively. The performance of this bedside score was confirmed in CAP patients of
the validation cohort although calibration was not successful in patients with health care-associated
pneumonia (HCAP). The expanded CURB-65 is objective, simpler and more accurate scoring system for
evaluation of CAP severity, and the predictive efficiency was better than other score systems
Disturbance Rejection Control for Autonomous Trolley Collection Robots with Prescribed Performance
Trajectory tracking control of autonomous trolley collection robots (ATCR) is
an ambitious work due to the complex environment, serious noise and external
disturbances. This work investigates a control scheme for ATCR subjecting to
severe environmental interference. A kinematics model based adaptive sliding
mode disturbance observer with fast convergence is first proposed to estimate
the lumped disturbances. On this basis, a robust controller with prescribed
performance is proposed using a backstepping technique, which improves the
transient performance and guarantees fast convergence. Simulation outcomes have
been provided to illustrate the effectiveness of the proposed control scheme
DNA binding mechanism revealed by high resolution crystal structure of Arabidopsis thaliana WRKY1 protein
WRKY proteins, defined by the conserved WRKYGQK sequence, are comprised of a large superfamily of transcription factors identified specifically from the plant kingdom. This superfamily plays important roles in plant disease resistance, abiotic stress, senescence as well as in some developmental processes. In this study, the Arabidopsis WRKY1 was shown to be involved in the salicylic acid signaling pathway and partially dependent on NPR1; a C-terminal domain of WRKY1, AtWRKY1-C, was constructed for structural studies. Previous investigations showed that DNA binding of the WRKY proteins was localized at the WRKY domains and these domains may define novel zinc-binding motifs. The crystal structure of the AtWRKY1-C determined at 1.6āĆ
resolution has revealed that this domain is composed of a globular structure with five Ī² strands, forming an antiparallel Ī²-sheet. A novel zinc-binding site is situated at one end of the Ī²-sheet, between strands Ī²4 and Ī²5. Based on this high-resolution crystal structure and site-directed mutagenesis, we have defined and confirmed that the DNA-binding residues of AtWRKY1-C are located at Ī²2 and Ī²3 strands. These results provided us with structural information to understand the mechanism of transcriptional control and signal transduction events of the WRKY proteins
- ā¦