George W. Norris The Making of a Progressive 1861-1912

Tins first detailed biography of Morris traces the great liberal\u27s Me, views, and political develop ment to his entrance into the U.S. Senate in 1913. In examining the metamorphosis of a rising young lawyer with mortgage interests into a leader of the Progressive movement, the book gives a thorough account of the political growth and maturing of a man who became one of the foremost legislators in American history.https://surface.syr.edu/books/1004/thumbnail.jp

George W. Norris : the making of a progressive 1861-1912

Tins first detailed biography of Morris traces the great liberal\u27s Me, views, and political develop ment to his entrance into the U.S. Senate in 1913. In examining the metamorphosis of a rising young lawyer with mortgage interests into a leader of the Progressive movement, the book gives a thorough account of the political growth and maturing of a man who became one of the foremost legislators in American history

Chronicles of Oklahoma

Article provides an overview of the political career of Almer Stillwell "Mike" Monroney, who served the people of Oklahoma in the US House of Representatives and US Senate from 1939 until 1966. The author characterizes Monroney as a level-headed moderate attempting to continue his tenure in office amidst a shift to the conservative right in Oklahoma politics

Chronicles of Oklahoma

The second part of a two-part article, this article continues the examination of the effect that economic distress and political policies had on Oklahoma's farmers and ranchers in the 1970s and 1980s

Chronicles of Oklahoma

Article covers the Oklahoma City worker's strike in 1969 when sanitation workers, mostly African Americans, went on strike for higher wages and better working conditions. The article expounds on the reasons for the strike, the attention it received locally and nationally from African American politicians and organizations, and the results of the resolve of the strikers and their supporters

Chronicles of Oklahoma

This article is the first part of a two-part article that examines the effect that economic distress and political policies had on Oklahoma farmers and ranchers during the 1970s and 1980s

Chronicles of Oklahoma

Corrections section from Volume 91, Number 2, Summer 2013. It includes a correction to the map on page 412 of the article "A Separate People: A History of the Oklahoma Amish" from Volume 90 Number 4, Winter 2012-13. It also includes a correction to a photograph label on page 33 in the article "The Enigma of Mike Monroney" from Volume 91, Number 1, Spring 2013

Genomic profiling reveals the potential role of TCL1A and MDR1 Deficiency in chemotherapy-induced cardiotoxicity

Background: Anthracyclines, such as doxorubicin (Adriamycin), are highly effective chemotherapeutic agents, but are well known to cause myocardial dysfunction and life-threatening congestive heart failure (CHF) in some patients. Methods: To generate new hypotheses about its etiology, genome-wide transcript analysis was performed on whole blood RNA from women that received doxorubicin-based chemotherapy and either did, or did not develop CHF, as defined by ejection fractions (EF)≤40%. Women with non-ischemic cardiomyopathy unrelated to chemotherapy were compared to breast cancer patients prior to chemo with normal EF to identify heart failure-related transcripts in women not receiving chemotherapy. Byproducts of oxidative stress in plasma were measured in a subset of patients. Results: The results indicate that patients treated with doxorubicin showed sustained elevations in oxidative byproducts in plasma. At the RNA level, women who exhibited low EFs after chemotherapy had 260 transcripts that differed \u3e2-fold (pIn vitro studies confirmed that inhibition of MDR1 by verapamil in rat H9C2 cardiomyocytes increased their susceptibility to doxorubicin-induced toxicity. Conclusions: It is proposed that chemo-induced cardiomyopathy may be due to a reduction in TCL1A levels, thereby causing increased apoptotic sensitivity, and leading to reduced cardiac MDR1 levels, causing higher cardiac levels of doxorubicin and intracellular free radicals. If so, screening for TCL1A and MDR1 SNPs or expression level in blood, might identify women at greatest risk of chemo-induced heart failure