Zebrafish as a model for kidney function and disease

Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease

Recursive Complements and Propositional Attitudes

The focus of this chapter is in what role syntactic recursion might play in the representation of propositional attitudes. Syntactic complements under mental and communication verbs are recursive, and so also are the propositional attitudes. There is strong evidence that children take some time to master the first order syntactic complementation typical of verbs of communication. When they do acquire these structures, the evidence suggests that this helps children reason about propositional attitudes such as false beliefs. In this chapter we seek to deepen our understanding of the crucial property of sentential and attitude embedding. Is the crucial aspect that the truth value of the complement differs from that of the embedded clause, or is it that both the sentence forms and the propositional attitudes are recursive? We show that new insight can be gained by examining higher order levels of both sentence embedding and propositional attitudes. Based on some empirical data on second order complements and propositional attitude reasoning in children, we propose that truth contrasts between clauses may provide a crucial trigger for recursive complements

Putting unicepts to work : a teleosemantic perspective on the infant mindreading puzzle

In this paper, I show how theoretical discussion of recent research on the abilities of infants and young children to represent other agents’ beliefs has been shaped by a descriptivist conception of mental content, i.e., to the notion that the distal content of a mental representation is fixed by the core body of knowledge that is associated with that mental representation. I also show how alternative conceptions of mental content—and in particular Ruth Millikan’s teleosemantic approach—make it possible to endorse the view that infants have the ability to track beliefs by as early as 6 months while failing to understand some of the ways in which beliefs combine with each other and with other mental states in contributing to inferences and actions. In articulating this view, I will draw upon Millikan’s recently developed notion of ‘unicepts’. Unicepts, according to Millikan, are the basic representational vehicles that underpin our abilities to (re-) identify objects, properties, relations and kinds. When applied to research on mindreading in infancy and early childhood, Millikan’s approach generates fruitful new questions about the development of belief reasoning, and about the functions of belief reasoning in infancy and at different stages of childhood