Electronic marking and identification techniques to discourage document copying

Modern computer networks make it possible to distribute documents quickly and economically by electronic means rather than by conventional paper means. However, the widespread adoption of electronic distribution of copyrighted material is currently impeded by the ease of illicit copying and dissemination. In this paper we propose techniques that discourage illicit distribution by embedding each document with a unique codeword. Our encoding techniques are indiscernible by readers, yet enable us to identify the sanctioned recipient of a document by examination of a recovered document. We propose three coding methods, describe one in detail, and present experimental results showing that our identification techniques are highly reliable, even after documents have been photocopied

Once more about gauge invariance in \phi\to\gamma\pi0\pi0

It is argued that the realization of gauge invariance condition as a consequent of cancellation between the \phi\to\gamma f0\to\gamma\pi0\pi0 resonance contribution and a \phi\to\gamma\pi0\pi0 background one, suggested in Ref. [1], is misleading.Comment: 4 pages, one reference adde

Glyoxal 4-nitrophenylhydrazone : triple helices linked into a three-dimensional channel structure

Peer reviewedPublisher PD

Investigating ethnic inequalities in the incidence of sexually transmitted infections: mathematical modelling study.

OBJECTIVES: To investigate ethnic differences in rates of gonorrhoea using empirical sexual behaviour data in a simple mathematical model. To explore the impact of different intervention strategies in this simulated population. METHODS: The findings from cross sectional studies of gonorrhoea rates and sexual behaviour in three ethnic groups in south east London were used to determine the parameters for a deterministic, mathematical model of gonorrhoea transmission dynamics, in a population stratified by sex, sexual activity (rate of partner change), and ethnic group (white, black African, and black Caribbean). We compared predicted and observed rates of infection and simulated the effects of targeted and population-wide intervention strategies. RESULTS: In model simulations the reported sexual behaviours and mixing patterns generated major differences in the rates of gonorrhoea experienced by each subpopulation. The fit of the model to observed data was sensitive to assumptions about the degree of mixing by level of sexual activity, the numbers of sexual partnerships reported by men and women, and the degree to which observed data underestimate female infection rates. Interventions to reduce duration of infection were most effective when targeted at black Caribbeans. CONCLUSIONS: Average measures of sexual behaviour in large populations are inadequate descriptors for the epidemiology of gonorrhoea. The consistency between the model results and empirical data shows that profound differences in gonorrhoea rates between ethnic groups can be explained by modest differences in a limited number of sexual behaviours and mixing patterns. Targeting effective services to particular ethnic groups can have a disproportionate influence on disease reduction in the whole community

Magnetic Resonance Imaging of the Gastrointestinal Tract

MRI provides comprehensive information on gastrointestinal diseases, including infectious, inflammatory, and malignant processes. We employ a set protocol incorporating breath‐hold SS RARE imaging combined with gadolinium‐enhanced, fat‐suppressed SPGR imaging in the transverse and coronal planes. Bowel distension is accomplished with inexpensive water‐soluble intraluminal contrast agents.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145250/1/cpmia2901.pd

Chlamydia control activities in Europe: cross-sectional survey

Background: Chlamydia is the most commonly reported bacterial sexually transmitted infection in Europe. The objective of the Screening for Chlamydia in Europe (SCREen) project was to describe current and planned chlamydia control activities in Europe. Methods: The authors sent a questionnaire asking about different aspects of chlamydia epidemiology and control to public health and clinical experts in each country in 2007. The principles of sexually transmitted infection control were used to develop a typology comprising five categories of chlamydia control activities. Each country was assigned to a category, based on responses to the questionnaire. Results: Experts in 29 of 33 (88%) invited countries responded. Thirteen of 29 countries (45%) had no current chlamydia control activities. Six countries in this group stated that there were plans to introduce chlamydia screening programmes. There were five countries (17%) with case management guidelines only. Three countries (10%) also recommended case finding amongst partners of diagnosed chlamydia cases or people with another sexually transmitted infection. Six countries (21%) further specified groups of asymptomatic people eligible for opportunistic chlamydia testing. Two countries (7%) reported a chlamydia screening programme. There was no consistent association between the per capita gross domestic product of a country and the intensity of chlamydia control activities (P = 0.816). Conclusion: A newly developed classification system allowed the breadth of ongoing national chlamydia control activities to be described and categorized. Chlamydia control strategies should ensure that clinical guidelines to optimize chlamydia diagnosis and case management have been implemented before considering the appropriateness of screening programmes

Hydrogen bonding in C-methylated nitroanilines : the three-dimensional framework structure of 2-methyl-4-nitroaniline

Peer reviewedPublisher PD

A review of cytokine-based pathophysiology of Long COVID symptoms

The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is prolonged, or new symptoms are developed over months. Here, we propose a description of the pathophysiology of the Long COVID presentation based on inflammatory cytokine cascades and the p38 MAP kinase signaling pathways that regulate cytokine production. In this model, the SARS-CoV-2 viral infection is hypothesized to trigger a dysregulated peripheral immune system activation with subsequent cytokine release. Chronic low-grade inflammation leads to dysregulated brain microglia with an exaggerated release of central cytokines, producing neuroinflammation. Immunothrombosis linked to chronic inflammation with microclot formation leads to decreased tissue perfusion and ischemia. Intermittent fatigue, Post Exertional Malaise (PEM), CNS symptoms with "brain fog," arthralgias, paresthesias, dysautonomia, and GI and ophthalmic problems can consequently arise as result of the elevated peripheral and central cytokines. There are abundant similarities between symptoms in Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). DNA polymorphisms and viral-induced epigenetic changes to cytokine gene expression may lead to chronic inflammation in Long COVID patients, predisposing some to develop autoimmunity, which may be the gateway to ME/CFS

A triclinic polymorph of benzanilide : disordered molecules form hydrogen-bonded chains

Peer reviewedPublisher PD