Surveillance of resistance in bacteria causing community‐acquired respiratory tract infections

Bacterial resistance to antibiotics in community‐acquired respiratory tract infections is a serious problem and is increasing in prevalence world‐wide at an alarming rate. Streptococcus pneumoniae, one of the main organisms implicated in respiratory tract infections, has developed multiple resistance mechanisms to combat the effects of most commonly used classes of antibiotics, particularly the β‐lactams (penicillin, aminopenicillins and cephalosporins) and macrolides. Furthermore, multidrug‐resistant strains of S. pneumoniae have spread to all regions of the world, often via resistant genetic clones. A similar spread of resistance has been reported for other major respiratory tract pathogens, including Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes. To develop and support resistance control strategies it is imperative to obtain accurate data on the prevalence, geographic distribution and antibiotic susceptibility of respiratory tract pathogens and how this relates to antibiotic prescribing patterns. In recent years, significant progress has been made in developing longitudinal national and international surveillance programs to monitor antibiotic resistance, such that the prevalence of resistance and underlying trends over time are now well documented for most parts of Europe, and many parts of Asia and the Americas. However, resistance surveillance data from parts of the developing world (regions of Central America, Africa, Asia and Central/Eastern Europe) remain poor. The quantity and quality of surveillance data is very heterogeneous; thus there is a clear need to standardize or validate the data collection, analysis and interpretative criteria used across studies. If disseminated effectively these data can be used to guide empiric antibiotic therapy, and to support—and monitor the impact of—interventions on antibiotic resistance

Radiative corrections to all charge assignments of heavy quark baryon semileptonic decays

In semileptonic decays of spin-1/2 baryons containing heavy quarks up to six charge assignments for the baryons and lepton are possible. We show that the radiative corrections to four of these possibilities can be directly obtained from the final results of the two possibilities previously studied. There is no need to recalculate integrals over virtual or real photon momentum or any traces.Comment: 15 pages, 2 figures, RevTex. Extended discussion. Final version to appear in Physical Review

Electroweak Precision Constraints on the Littlest Higgs Model with T Parity

We compute the leading corrections to the properties of W and Z bosons induced at the one-loop level in the SU(5)/SO(5) Littlest Higgs model with T parity, and perform a global fit to precision electroweak data to determine the constraints on the model parameters. We find that a large part of the model parameter space is consistent with data. Values of the symmetry breaking scale as low as 500 GeV are allowed, indicating that no significant fine tuning in the Higgs potential is required. We identify a region within the allowed parameter space in which the lightest T-odd particle, the partner of the hypercharge gauge boson, has the correct relic abundance to play the role of dark matter. In addition, we find that a consistent fit to data can be obtained for large values of the Higgs mass, up to 800 GeV, due to the possibility of a partial cancellation between the contributions to the T parameter from Higgs loops and new physics.Comment: 23 pages, 9 figures. Minor correction

Little Hierarchy, Little Higgses, and a Little Symmetry

Little Higgs theories are an attempt to address the little hierarchy problem, i.e., the tension between the naturalness of the electroweak scale and the precision measurements showing no evidence for new physics up to 5-10 TeV. In little Higgs theories, the Higgs mass-squareds are protected to the one-loop order from the quadratic divergence. This allows the cutoff to be raised up to \~10 TeV, beyond the scales probed by the precision data. However, strong constraints can still arise from the contributions of the new TeV scale particles and hence re-introduces the fine-tuning problem. In this paper we show that a new symmetry, denoted as T-parity, under which all heavy gauge bosons and scalar triplets are odd, can remove all the tree-level contributions to the electroweak observables and therefore makes the little Higgs theories completely natural. The T-parity can be manifestly implemented in a majority of little Higgs models by following the most general construction of the low energy effective theory a la Callan, Coleman, Wess and Zumino. In particular, we discuss in detail how to implement the T-parity in the littlest Higgs model based on SU(5)/SO(5). The symmetry breaking scale f can be even lower than 500 GeV if the contributions from the unknown UV physics at the cutoff are somewhat small. The existence of $T$-parity has drastic impacts on the phenomenology of the little Higgs theories. The T-odd particles need to be pair-produced and will cascade down to the lightest T-odd particle (LTP) which is stable. A neutral LTP gives rise to missing energy signals at the colliders which can mimic supersymmetry. It can also serve as a good dark matter candidate.Comment: 20 pages, 2 figures, RevTeX; v2: Yukawa sector in the SU(5)/SO(5) model slightly modified. Also added comments on the Dirac mass term for the fermionic doublet partner; v3: clarifying comments on the modified Yukawa sector. version to appear on JHE

Littlest Higgs model and associated ZH production at high energy e+e−e^{+}e^{-} collider

In the context of the littlest Higgs (LH) model, we consider the Higgs strahlung process $e^{+}e^{-}\to ZH$. We find that the correction effects on this process mainly come from the heavy photon $B'$. If we take the mixing angle parameter $c$ in the range of 0.75 - 1, the contributions of the heavy gauge boson $W_{3}'$ is larger than 6%. In most of the parameter space, the deviation of the total production cross section $\sigma^{tot}$ from its SM value is larger than 5%, which may be detected in the future high energy $e^{+}e^{-}$ collider (LC) experiments. The future LC experiments could test the LH model by measuring the cross section of the process $e^{+}e^{-}\to ZH$.Comment: 13 pages, 3 figure

The Littlest Higgs in Anti-de Sitter Space

We implement the SU(5)/SO(5) littlest Higgs theory in a slice of 5D Anti-de Sitter space bounded by a UV brane and an IR brane. In this model, there is a bulk SU(5) gauge symmetry that is broken to SO(5) on the IR brane, and the Higgs boson is contained in the Goldstones from this breaking. All of the interactions on the IR brane preserve the global symmetries that protect the Higgs mass, but a radiative potential is generated through loops that stretch to the UV brane where there are explicit SU(5) violating boundary conditions. Like the original littlest Higgs, this model exhibits collective breaking in that two interactions must be turned on in order to generate a Higgs potential. In AdS space, however, collective breaking does not appear in coupling constants directly but rather in the choice of UV brane boundary conditions. We match this AdS construction to the known low energy structure of the littlest Higgs and comment on some of the tensions inherent in the AdS construction. We calculate the 5D Coleman-Weinberg effective potential for the Higgs and find that collective breaking is manifest. In a simplified model with only the SU(2) gauge structure and the top quark, the physical Higgs mass can be of order 200 GeV with no considerable fine tuning (25%). We sketch a more realistic model involving the entire gauge and fermion structure that also implements T-parity, and we comment on the tension between T-parity and flavor structure.Comment: 42 pages, 7 figures, 3 tables; v2: minor rewording, JHEP format; v3: to match JHEP versio

What Precision Electroweak Physics Says About the SU(6)/Sp(6) Little Higgs

We study precision electroweak constraints on the close cousin of the Littlest Higgs, the SU(6)/Sp(6) model. We identify a near-oblique limit in which the heavy W' and B' decouple from the light fermions, and then calculate oblique corrections, including one-loop contributions from the extended top sector and the two Higgs doublets. We find regions of parameter space that give acceptably small precision electroweak corrections and only mild fine tuning in the Higgs potential, and also find that the mass of the lightest Higgs boson is relatively unconstrained by precision electroweak data. The fermions from the extended top sector can be as light as 1 TeV, and the W' can be as light as 1.8 TeV. We include an independent breaking scale for the B', which can still have a mass as low as a few hundred GeV.Comment: 52 pages, 16 figure

The Intermediate Higgs

Two paradigms for the origin of electroweak superconductivity are a weakly coupled scalar condensate, and a strongly coupled fermion condensate. The former suffers from a finetuning problem unless there are cancelations to radiative corrections, while the latter presents potential discrepancies with precision electroweak physics. Here we present a framework for electroweak symmetry breaking which interpolates between these two paradigms, and mitigates their faults. As in Little Higgs theories, the Higgs is a pseudo-Nambu Goldstone boson, potentially composite. The cutoff sensitivity of the one loop top quark contribution to the effective potential is canceled by contributions from additional vector-like quarks, and the cutoff can naturally be higher than in the minimal Standard Model. Unlike the Little Higgs models, the cutoff sensitivity from one loop gauge contributions is not canceled. However, such gauge contributions are naturally small as long as the cutoff is below 6 TeV. Precision electroweak corrections are suppressed relative to those of Technicolor or generic Little Higgs theories. In some versions of the intermediate scenario, the Higgs mass is computable in terms of the masses of these additional fermions and the Nambu-Goldstone Boson decay constant. In addition to the Higgs, new scalar and pseudoscalar particles are typically present at the weak scale

KK Parity in Warped Extra Dimension

We construct models with a Kaluza-Klein (KK) parity in a five- dimensional warped geometry, in an attempt to address the little hierarchy problem present in setups with bulk Standard Model fields. The lightest KK particle (LKP) is stable and can play the role of dark matter. We consider the possibilities of gluing two identical slices of 5D AdS in either the UV (IR-UV-IR model) or the IR region (UV-IR-UV model) and discuss the model-building issues as well as phenomenological properties in both cases. In particular, we find that the UV-IR-UV model is not gravitationally stable and that additional mechanisms might be required in the IR-UV-IR model in order to address flavor issues. Collider signals of the warped KK parity are different from either the conventional warped extra dimension without KK parity, in which the new particles are not necessarily pair-produced, or the KK parity in flat universal extra dimensions, where each KK level is nearly degenerate in mass. Dark matter and collider properties of a TeV mass KK Z gauge boson as the LKP are discussed.Comment: 35 pages, 11 figure