Supplemental material for Development of a Core Outcome Set for research on critically ill obstetric patients: A study protocol

<p>Supplemental material for Development of a Core Outcome Set for research on critically ill obstetric patients: A study protocol by Julien Viau-Lapointe, Rohan D’Souza, Louise Rose and Stephen E Lapinsky in Obstetric Medicine</p

Partial Ventilatory Support Modalities in Acute Lung Injury and Acute Respiratory Distress Syndrome—A Systematic Review

<div><h3>Purpose</h3><p>The efficacy of partial ventilatory support modes that allow spontaneous breathing in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is unclear. The objective of this scoping review was to assess the effects of partial ventilatory support on mortality, duration of mechanical ventilation, and both hospital and intensive care unit (ICU) lengths of stay (LOS) for patients with ALI and ARDS; the secondary objective was to describe physiologic effects on hemodynamics, respiratory system and other organ function.</p> <h3>Methods</h3><p>MEDLINE (1966–2009), Cochrane, and EmBase (1980–2009) databases were searched using common ventilator modes as keywords and reference lists from retrieved manuscripts hand searched for additional studies. Two researchers independently reviewed and graded the studies using a modified Oxford Centre for Evidence-Based Medicine grading system. Studies in adult ALI/ARDS patients were included for primary objectives and pre-clinical studies for supporting evidence.</p> <h3>Results</h3><p>Two randomized controlled trials (RCTs) were identified, in addition to six prospective cohort studies, one retrospective cohort study, one case control study, 41 clinical physiologic studies and 28 pre-clinical studies. No study was powered to assess mortality, one RCT showed shorter ICU length of stay, and the other demonstrated more ventilator free days. Beneficial effects of preserved spontaneous breathing were mainly physiological effects demonstrated as improvement of gas exchange, hemodynamics and non-pulmonary organ perfusion and function.</p> <h3>Conclusions</h3><p>The use of partial ventilatory support modalities is often feasible in patients with ALI/ARDS, and may be associated with short-term physiological benefits without appreciable impact on clinically important outcomes.</p> </div

Summary of results for clinical studies.

<p>APACHE2: Acute Physiology and Chronic Health Evaluation 2 Score; ARF: acute renal failure; CI: cardiac index; CPPV: continuous positive pressure ventilation; CRS: compliance (respiratory system); DO2: oxygen delivery; PaO2: partial pressure of oxygen (mmHg); PMAX/PINFLATION : upper and lower (respectively) pressure levels in APRV/BIPAP mode; LIS: lung-injury score; NR: not reported; RASS: Richmond Agitation Severity Score; SOFA: sequential organ failure assessment; VT: tidal volume; all other abbreviations as stated previously in the text.</p

Modified Oxford Centre for Evidence-Based Medicine Levels of Evidence (8).

<p>RCT = randomized control trial; SR = systematic review. For definitions refer to text.</p

Additional file 6: of Barriers and facilitators to early rehabilitation in mechanically ventilated patients—a theory-driven interview study

Frequency of all Beliefs by Profession. (DOCX 29 kb

Targeted populations acceptability and perception of Motivational interviewing : A scoping review of MI from a cultural relativism and universalist perspective

Studien syftar till att undersöka olika målgruppers mottaglighet och uppfattning av Motiverande samtal (MI) utifrån ett universalistiskt och kulturrelativistiskt perspektiv. Bakgrunden är att MI är en frekvent använd samtalsmetod som används i det lösningsfokuserade sociala arbetet samt att en forskningslucka identifierats kring hur MI faktiskt tas emot och uppfattas av olika målgrupper. Studien avser analysera MI utfört i olika kontexter och utifrån både kulturrelativism och universalism. För att undersöka detta har en scoping review gjorts där 35 akademiska artiklar inom forskningsområdet valdes ut och sedan analyserades tematiskt. De fem teman som identifierats är mottaglighet och uppfattning av MI bland olika målgrupper, betydelsen av handledning och utbildning för olika målgruppers inställning till MI, MI:s påverkan för relationsbyggande och dess betydelse för mottagligheten och uppfattningen hos olika målgrupper, potentialen MI har i kombination med andra insatser för olika målgruppers mottaglighet och uppfattning, samt ökad mottaglighet och förbättrad uppfattning genom målgruppsanpassning av MI. Det huvudsakliga resultatet har varit att ett antal aspekter utifrån dessa teman bör beaktas och kan förstås bättre utifrån de två nämnda teoretiska perspektiven. Övergripande förefaller MI mottas och uppfattas väl av olika målgrupper, men flera studier tyder ändå på att resultatet av MI interventioner inte får en långvarig påverkan. The study aims to investigate the receptivity and perception of different target populations of Motivational Interviewing (MI) from a universalist and cultural relativistic perspective. The background is that MI is a frequently used conversational method used in the solution-focused social work and that a research gap has been identified around how MI is received by different target groups. The study intends to analyse MI performed in different contexts and based on both cultural relativism and universalism. To investigate this, a scoping review has been made where 35 academic articles in the research area were selected and then analysed thematically. The five themes identified are receptivity and perception of MI among different target populations, the importance of guidance and education for different target populations attitude to MI, MI's impact on relationship building and its significance for receptivity and perception in different target populations, the potential MI has in combination with other initiatives for the receptivity and perception of different target populations, as well as increased receptivity and improved perception through target populations adaptation of MI. The main result has been that several aspects based on these themes should be considered and can be better understood from the two mentioned theoretical perspectives. Overall, MI seems to be received and perceived well by different target populations, but several studies still indicate that the results of MI interventions do not have a long-term impact

Additional file 1: of Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol

Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P). PRISMA-P items and their respective line locations within the manuscript. (DOCX 135 kb

Brown Queers screened at Leeds Queer Film Festival

Shown at Leeds Queer Festival: Brown Queers (Michelle Williams Gamaker, 2017) Brown Queers developed out of a need to create a social document of current modes of identity through multiple personas and styles. The protagonists of Brown Queers explore such modes through their conscious decision to be gender fluid and non-binary. For the past eight months, I have been following Krishna Istha, Katy Jalili and Natasha Lall, all individuals who identify as queer and brown. Beyond this, complexities related to nationality, race, gender and sexuality play out through their bodies and in the different contexts in which they live and work: the film thus acts as a record of these individuals in contemporary Britain. Brown Queers poses questions that come out of the layered states of being that embody fluidity, “browness” and “queerness”. I have authored the work, but it is very much a conversation about presenting and framing the individual. During shoots, an idea is posed and the result is a docu-fiction, located between the verité of Jean Rouch’s Chronique d'un été [Chronicle of a Summer] (1961) and the illusion of realism in highly stylised films such as Lachapelle’s Rize (2005). Thus far, locations have been varied, following each subject at home, in tattoo parlours, in clubs or performing on stage. The plan is to “voice” thoughts so that their bodies speak, rather than via direct conversation to camera, in order to offer a multiplicity of voices, a plural body, where three individuals contribute to a wider monologue that speaks for many experiencing the unknown territory of identity as identities. Just as Rouch and sociologist Edgar Morin question whether or not it is possible to act sincerely in front of a camera. I wish to complicate the framing of the individual through thought, as monologues toy with the conscious fictionalising of self through costume, make-up and the body politic. The sequence in the teaser trailer was shot at Central London bar Sketch, a space very much part of the establishment and thus embodying privilege. I wanted the brown queers to be visible within the stylised pink décor, thereby intentionally playing with the stereotypically gendered colour scheme for girls or women. Under the guidance of expert trans hair and make-up beauty stylist Umber Ghauri, Krishna, Katy and Natasha transform into their chosen identities against the tableaux-vivant of Sketch’s main dining room. As a person of colour and a queer filmmaker, the significance of this project is key to my work both personally and politically

Supplemental Material - Left ventricular unloading in patients supported with veno-arterial extra corporeal membrane oxygenation; an international EuroELSO survey

Supplemental Material for Left ventricular unloading in patients supported with veno-arterial extra corporeal membrane oxygenation; an international EuroELSO survey by Saad M Ezad, Matthew Ryan, Nicholas Barrett, Luigi Camporota, Justyna Swol, Marta V Antonini, Dirk W Donker, Federico Pappalardo, Navin K Kapur, Louise Rose and Divaka Perera in Perfusion</p

Additional file 1 of Clinical impact of screening computed tomography in extracorporeal membrane oxygenation: a retrospective cohort study

Additional file 1: Additional Tables, Tables S1-S5