Spin-wave analysis of the transverse-field Ising model on the checkerboard lattice

The ground state properties of the S=1/2 transverse-field Ising model on the checkerboard lattice are studied using linear spin wave theory. We consider the general case of different couplings between nearest neighbors (J1) and next-to-nearest neighbors (J2). In zero field the system displays a large degeneracy of the ground state, which is exponential in the system size (for J1=J2) or in the system's linear dimensions (for J2>J1). Quantum fluctuations induced by a transverse field are found to be unable to lift this degeneracy in favor of a classically ordered state at the harmonic level. This remarkable fact suggests that a quantum-disordered ground state can be instead promoted when non-linear fluctuations are accounted for, in agreement with existing results for the isotropic case J1=J2. Moreover spin-wave theory shows sizable regions of instability which are further candidates for quantum-disordered behavior.Comment: 12 pages, 13 figure

Imaging correlates of molecular signatures in oligodendrogliomas.

Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T(1) images and mixed intensity signal on T(1) and T(2). Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms

Effects of foam on ocean surface microwave emission inferred from radiometric observations of reproducible breaking waves

Includes bibliographical references.WindSat, the first satellite polarimetric microwave radiometer, and the NPOESS Conical Microwave Imager/Sounder both have as a key objective the retrieval of the ocean surface wind vector from radiometric brightness temperatures. Available observations and models to date show that the wind direction signal is only 1-3 K peak-to-peak at 19 and 37 GHz, much smaller than the wind speed signal. In order to obtain sufficient accuracy for reliable wind direction retrieval, uncertainties in geophysical modeling of the sea surface emission on the order of 0.2 K need to be removed. The surface roughness spectrum has been addressed by many studies, but the azimuthal signature of the microwave emission from breaking waves and foam has not been adequately addressed. RECENtly, a number of experiments have been conducted to quantify the increase in sea surface microwave emission due to foam. Measurements from the Floating Instrumentation Platform indicated that the increase in ocean surface emission due to breaking waves may depend on the incidence and azimuth angles of observation. The need to quantify this dependence motivated systematic measurement of the microwave emission from reproducible breaking waves as a function of incidence and azimuth angles. A number of empirical parameterizations of whitecap coverage with wind speed were used to estimate the increase in brightness temperatures measured by a satellite microwave radiometer due to wave breaking in the field of view. These results provide the first empirically based parameterization with wind speed of the effect of breaking waves and foam on satellite brightness temperatures at 10.8, 19, and 37 GHz.This work was supported in part by the Department of the Navy, Office of Naval Research under Awards N00014-00-1-0615 (ONR/YIP) and N00014-03-1-0044 (Space and Remote Sensing) to the University of Massachusetts Amherst, and N00014-00-1-0152 (Space and Remote Sensing) to the University of Washington. The National Polar-orbiting Operational environmental Satellite System Integrated Program Office supported the Naval Research Laboratory's participation through Award NA02AANEG0338 and supported data analysis at Colorado State University and the University of Washington through Award NA05AANEG0153

Point-of-admission hypoglycaemia among under-five nigerian children with plasmodium falciparum malaria: Prevalence and risk factors

Background: Hypoglycaemia is a well recognized complication of falciparum malaria in children but its diagnosis may be overlooked because all the clinical features may mimic those of severe malaria.Objective: To determine the prevalence of hypoglycaemia at the point of hospital admission of under-fives with falciparum malaria and identify its risk factors in patients seen in a Nigerian secondary-health-care institution.Methods: At the point of admission, venous blood sample was collected into an appropriate sample bottle (fluoride oxalate bottle) from 502 children who were below 5 years old for malaria parasites (Giemsa stain). The blood sample was analysed for glucose using the glucose oxidase method. The time of last meal was noted.Results: Ninety two (18.3%) of 502 children with falciparum malaria had hypoglycaemia ( blood glucose below 2.6 mmol/L) at the point of hospital admission. Twenty three percent, 78 of 339 children below 36 months of age were hypoglycaemic compared to 8.6%, 14 of 163 children aged 36 months and above; p < 0.01. Prevalence of hypoglycaemia was higher in girls than boys; 20.7% versus 16.3%, Odd ratio, OR = 1.3 (95% Confidence Interval, CI = 0.692-1.815). Forty of 305 children (13.1%) in whom the time of last meal was less than 12 hours had hypoglycaemia compared to 52 of 197 (26.4%) in whom the time of last meal was greater than 12 hours; p < 0.05. The duration of illness and the degree of parasitaemia did not have significant bearing with the prevalence of hypoglycaemia.Conclusion: Hypoglycaemia do occur at point of hospital admission among under-fives with falciparum malaria, with age below 36 months and time of last meal greater than 12 hours being important risk factors. Routine monitoring of blood glu­cose at point of admission is suggested

Gene expression in Leishmania is regulated predominantly by gene dosage

ABSTRACT Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here, we report the genome sequence of this pathogen and 7,863 identified protein-coding genes, and we show that the majority of clinical isolates possess high levels of allelic diversity, genetic admixture, heterozygosity, and extensive aneuploidy. By utilizing paired genome-wide high-throughput DNA sequencing (DNA-seq) with RNA-seq, we found that gene dosage, at the level of individual genes or chromosomal “somy” (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85% of total gene expression variation in genes with a 2-fold or greater change in expression. High gene copy number variation (CNV) among membrane-bound transporters, a class of proteins previously implicated in drug resistance, was found for the most highly differentially expressed genes. Our results suggest that gene dosage is an adaptive trait that confers phenotypic plasticity among natural Leishmania populations by rapid down- or upregulation of transporter proteins to limit the effects of environmental stresses, such as drug selection. IMPORTANCE Leishmania is a genus of unicellular eukaryotic parasites that is responsible for a spectrum of human diseases that range from cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL) to life-threatening visceral leishmaniasis (VL). Developmental and strain-specific gene expression is largely thought to be due to mRNA message stability or posttranscriptional regulatory networks for this species, whose genome is organized into polycistronic gene clusters in the absence of promoter-mediated regulation of transcription initiation of nuclear genes. Genetic hybridization has been demonstrated to yield dramatic structural genomic variation, but whether such changes in gene dosage impact gene expression has not been formally investigated. Here we show that the predominant mechanism determining transcript abundance differences (>85%) in Leishmania tropica is that of gene dosage at the level of individual genes or chromosomal somy

A Revised Orbital Ephemeris for HAT-P-9b

We present here three transit observations of HAT-P-9b taken on 14 February 2010, 18 February 2010, and 05 April 2010 UT from the University of Arizona's 1.55 meter Kuiper telescope on Mt. Bigelow. Our transit light curves were obtained in the I filter for all our observations, and underwent the same reduction process. All three of our transits deviated significantly (approximately 24 minutes earlier) from the ephemeris of Shporer et al. (2008). However, due to the large time span between our observed transits and those of Shporer et al. (2008), a 6.5 second (2 sigma) shift downwards in orbital period from the value of Shporer et al. (2008) is sufficient to explain all available transit data. We find a new period of 3.922814 +/- 0.000002 days for HAT-P-9b with no evidence for significant nonlinearities in the transit period.Comment: 10 pages, 3 figure

Intrinsic ELMing in ASDEX Upgrade and global control system-plasma self-entrainment

It is well established that edge localized modes can be entrained to the frequency of applied global magnetic perturbations. These perturbations are delivered to the plasma using the vertical control system field coil currents. These field coils are part of an active control system that is required to maintain the plasma in a steady state. We perform time domain timeseries analysis of natural ELMing when there are no applied perturbations in the ASDEX Upgrade tokamak. We find that the plasma can transition into a state in which the control system field coil currents continually oscillate and are synchronized with oscillations in characteristic plasma parameters such as plasma edge position and total MHD energy. These synchronous oscillations have a one-to-one correlation with the naturally occurring ELMs; the ELMs all occur when the control system coil current is around a specific temporal phase. Large and small ELMs may be distinguished by the amplitude of inward movement of the edge following an ELM. Large ELMs are then found to occur preferentially around a specific temporal phase of the vertical position control coil current. Small ELMs are most likely in antiphase to this. The large and small natural ELMs occur at the opposite extrema of the oscillations in the control system vertical position control coil current. The control system coil current phase may thus provide a useful parameter to order the observed ELM dynamics. We have identified a class of natural ELMing which is a self-entrained state, in which there is a continual non-linear feedback between the global plasma dynamics and the active control system that is intrinsic to the cyclic dynamics of naturally occurring ELMs. Control system-plasma feedback thus becomes an essential component for integration into future models of natural ELM dynamics