Schnittstellenaufgaben in Analysis I – Wie können sie aussehen und wie hilfreich sind sie?

Frohn D, Lotz J. Schnittstellenaufgaben in Analysis I – Wie können sie aussehen und wie hilfreich sind sie? In: Gesellschaft für Didaktik der Mathematik, ed. Beiträge zum Mathematikunterricht 2020. 2020

Gadolinium-based Contrast Agents for Cardiac MRI:Use of Linear and Macrocyclic Agents with Associated Safety Profile from 154 779 European Patients

Purpose: To assess current use and acute safety profiles of gadolinium-based contrast agents (GBCAs) in cardiac MRI given recent suspensions of GBCA approval. Materials and Methods: Patients were retrospectively included from the multinational multicenter European Society of Cardiovascular Radiology (ESCR) MR/CT Registry collected between January 2013 and October 2019. GBCA-associated acute adverse events (AAEs) were classified as mild (self-limiting), moderate (pronounced AAE requiring medical management), and severe (life threatening). Multivariable generalized linear mixed-effect models were used to assess AAE likelihood. Results: A total of 154 779 patients (average age, 53 years ± 19 [standard deviation]; 99 106 men) who underwent cardiac MRI were included, the majority of whom underwent administration of GBCAs (94.2% [n = 145 855]). While linear GBCAs were used in 15.2% of examinations through 2011, their use decreased to less than 1% in 2018 and 2019. Overall, 0.36% (n = 556) of AAEs were documented (mild, 0.12% [n = 178]; moderate, 0.21% [n = 331]; severe, 0.03% [n = 47]). For nonenhanced cardiac MRI, examination-related events were reported in 2.59% (231 of 8924) of cases, the majority of which were anxiety (0.98% [n = 87]) and dyspnea (0.93% [n = 83]). AAE rates varied significantly by pharmacologic stressor, GBCA molecular structure (macrocyclic vs linear GBCA: multivariable odds ratio, 0.634; 95% confidence interval: 0.452, 0.888; P = .008), GBCA subtype, and imaging indication. Conclusion: Gadolinium-based contrast agent administration changed according to recent regulatory decisions, with use of macrocyclic agents almost exclusively in 2018 and 2019; these agents also demonstrated a favorable acute safety profile.Supplemental material is available for this article.© RSNA, 2020

On the Color Magnitude Relation of Early-type Galaxies

In this letter we present a study of the color magnitude relation of 468 early-type galaxies in the Virgo Cluster with Sloan Digital Sky Survey imaging data. The analysis of our homogeneous, model-independent data set reveals that, in all colors (u-g, g-r, g-i, i-z) similarly, giant and dwarf early-type galaxies follow a continuous color magnitude relation (CMR) that is best described by an S-shape. The magnitude range and quality of our data allows us to clearly confirm that the CMR in Virgo is not linear. Additionally, we analyze the scatter about the CMR and find that it increases in the intermediate-luminosity regime. Nevertheless, despite this observational distinction, we conclude from the similarly shaped CMR of semi-analytic model predictions that dwarfs and giants could be of the same origin.Comment: Accepted by ApJL; 5 pages, 3 figures; added missing line to Figure

Serum glial fibrillary acidic protein and neurofilament light chain in patients with early treated phenylketonuria

To pave the way for healthy aging in early treated phenylketonuria (ETPKU) patients, a better understanding of the neurological course in this population is needed, requiring easy accessible biomarkers to monitor neurological disease progression in large cohorts. The objective of this pilot study was to investigate the potential of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) as blood biomarkers to indicate changes of the central nervous system in ETPKU. In this single-center cross-sectional study, GFAP and NfL concentrations in serum were quantified using the Simoa® multiplex technology in 56 ETPKU patients aged 6–36 years and 16 age matched healthy controls. Correlation analysis and hierarchical linear regression analysis were performed to investigate an association with disease-related biochemical parameters and retinal layers assessed by optical coherence tomography. ETPKU patients did not show significantly higher GFAP concentrations (mean 73 pg/ml) compared to healthy controls (mean 60 pg/ml, p = 0.140). However, individual pediatric and adult ETPKU patients had GFAP concentrations above the healthy control range. In addition, there was a significant association of GFAP concentrations with current plasma tyrosine concentrations (r = −0.482, p = 0.036), a biochemical marker in phenylketonuria, and the retinal inner nuclear layer volume (r = 0.451, p = 0.04). There was no evidence of NfL alterations in our ETPKU cohort. These pilot results encourage multicenter longitudinal studies to further investigate serum GFAP as a complementary tool to better understand and monitor neurological disease progression in ETPKU. Follow-up investigations on aging ETPKU patients are required to elucidate the potential of serum NfL as biomarker