PARPi related toxicities: do we need more appropriate instruments to evaluate it?

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Chemotherapy-free treatments: are we ready for prime time?

Epithelial ovarian cancer (EOC) is most frequently diagnosed at an advanced stage and, despite high response rates to initial taxane-platinum-based chemotherapy, more than 70% of patients will develop recurrent disease and will receive several chemotherapy treatments. At present, the 5-year overall survival (OS) for women diagnosed with stage III–IV disease is 46% and patients with genetic impairments of DNA repair pathways [BRCA mutations and in general homologous recombination deficiency (HRD)] live longer and possibly will receive even more lines of chemotherapy

IL CLIMA NEL VINO. METODI DI RICOSTRUZIONE E IMPATTI ECONOMICI DELLE FLUTTUAZIONI CLIMATICHE NELLE REGIONI VITIVINICOLE (SECOLI XVII-XX)

This study discusses the potential of wine quality as a new proxy data for the historical climatology. Wine-growing regions represent traditional areas of research since the beginnings of the discipline, when it was discovered the value of grape harvest dates (GHD) for the reconstruction of temperatures in the pre-instrumental period. However, annual meteorological variability exerts a considerable influence also on winemaking\u2019s results. To define the quality of wine we propose a quantitative index to convert narrative descriptions in vintage quality ratings. The analysis of the relationship between grape harvest dates and wine quality ratings shows significative correspondences in several European regions opening new perspectives of research for areas devoid of phenological data. Moreover, the information on vintages characteristics expands the meteorological knowledge available through the GHD series allowing useful suggestions about the seasonal distribution of temperature anomalies and precipitations. Finally, it was investigated also the role of the vintages quality in the economies of wine-growing regions, finding unexpected similarities in wine prices\u2019 historical trends of different European countries

Inhibition of cell migration and invasion mediated by the TAT-RasGAP317-326 peptide requires the DLC1 tumor suppressor.

TAT-RasGAP317-326, a peptide corresponding to the 317-326 sequence of p120 RasGAP coupled with a cell-permeable TAT-derived peptide, sensitizes the death response of various tumor cells to several anticancer treatments. We now report that this peptide is also able to increase cell adherence, prevent cell migration and inhibit matrix invasion. This is accompanied by a marked modification of the actin cytoskeleton and focal adhesion redistribution. Interestingly, integrins and the small Rho GTP-binding protein, which are well-characterized proteins modulating actin fibers, adhesion and migration, do not appear to be required for the pro-adhesive properties of TAT-RasGAP317-326. In contrast, deleted in liver cancer-1, a tumor suppressor protein, the expression of which is often deregulated in cancer cells, was found to be required for TAT-RasGAP317-326 to promote cell adherence and inhibit migration. These results show that TAT-RasGAP317-326, besides its ability to favor tumor cell death, hampers cell migration and invasion

Ectopic eruption of the first permanent molar in the maxilla: Cephalometric features of 13 pediatric patients

Ectopic eruption of the first permanent molar in the maxilla, generally characterized by the wrong axial positioning during eruption, is reported to occur in about 2–6% of children. Its incidence is surely under-estimated as it frequently remains undiagnosed and, additionally, becomes irreversible, resulting in posterior crowding in such cases. This retrospective study aims to investigate the cephalometric features of patients affected by ectopic eruption of the maxillary first molar in comparison to a control group of patients. From a total of 1935 subjects, 13 patients were enrolled in the study group, while 26 patients were randomly selected as a control group. Lateral cephalometric teleradiographs obtained at the time of diagnosis were used to measure cephalometric values between study patients and controls. The prevalence of ectopic eruption of the first maxillary permanent molar in our patients was 1.14%. The mandibular angle (SN-GoMe) was found to be significantly greater in the study group than in control. The same statistical trend was observed for the inter-maxillary angle (SnaSnp-GoMe); also, the distance Sna-Me was greater in the study group. Differences between groups were statistically significant for the following distances: Snp-Sna, Ba-S and SOR-Sna, which were found to be, overall, greater in the study group. Ectopic eruption of the first permanent molar in the maxilla seems to be associated with morphogenetic characteristics of patients, mainly with a dolichocephalic pattern

Post-test simulations for the NACIE-UP benchmark by STH codes

This paper illustrates the results obtained in the last phase of the NACIE-UP benchmark activity foreseen inside the EU SESAME Project. The purpose of this research activity, performed by system thermal–hydraulic (STH) codes, is finalized to the improvement, development and validation of existing STH codes for Heavy Liquid Metal (HLM) systems. All the participants improved their modelling of the NACIE-UP facility, respect to the initial blind simulation phase, adopting the actual experimental boundary conditions and reducing as much as possible sources of uncertainty in their numerical model. Four different STH codes were employed by the participants to the benchmark to model the NACIE-UP facility, namely: CATHARE for ENEA, ATHLET for GRS, RELAP5-3D© for the “Sapienza” University of Rome and RELAP5/Mod3.3(modified) for the University of Pisa. Three reference tests foreseen in the NACIE-UP benchmark and carried out at ENEA Brasimone Research Centre were analysed from four participants. The data from the post-test analyses, performed independently by the participant using different STH codes, were compared together and with the available experimental results and critically discussed

A figurational analysis of Health and/or Physical Education teacher educators’ conceptualisations of policy, and their sociogenesis

oai:repository.uel.ac.uk:8y81yPolicy engagement is key to promoting ‘quality’ physical education yet it has been identified as a ‘grand challenge’ for Health and/or Physical Education (H/PE) internationally. All H/PE professionals, including teacher educators, have a collective responsibility to engage with policy but existing research tells us little about how H/PE teacher educators (H/PETEs) understand and engage with policy. It is important to examine H/PETEs conceptualisations of policy for a few reasons, not least because teacher educators play a crucial role in supporting future generations of teachers who themselves will need to engage with policy as a core feature of their professional lives. Drawing on figurational sociology, and the concept of assemblage, this paper offers insights into the nature and development – or sociogenesis – of teacher educators’ conceptualisations of policy. The data shared in this paper was generated through semi-structured interviews with 12 H/PETE from 7 countries. Inductive-deductive analysis – drawing largely on figurational concepts such as interdependence, power, habitus and sociogenesis – revealed that H/PETEs conceptualised policy as: (i) informing intended action and change; (ii) a way to govern practice; (iii) imposition and possibility. In terms of how these conceptualisations came to be, key features of the H/PETE figuration that were identified as influential include: (i) interdependence with human and non-human elements; (ii) balances of power and (iii) social and individual habitus. It is concluded that capitalising on these elements through professional learning, for example, could support H/PETEs in engaging with policy in productive and meaningful ways. Given that engaging with policy is viewed as a collective responsibility of H/PETEs, and many – if not all – of the H/PETEs felt they needed support in this regard, this should be a key focus for the field

Determination of recombination length of a non-equilibrium plasma produced by laser ablation

An experimental study of the laser ablation produced plasma evolution is necessary for its deeper understanding, since plasma expansion has both spatially and temporally varying characteristics. We irradiated a Cu target with a KrF laser beam. A small Faraday cup array and an axial Faraday cup were used as diagnostic systems, in order to study the spatial variation in the total charge carried by plasma ions. Charge loss during the plasma expansion was observed, which was attributed to the charged species recombination. This occurred upstream to the critical distance where the plasma density is high enough. Downstream the critical distance the plasma particles collisions were negligible and the ion charge remained frozen. In these experiments it was observed that the critical distance for charge recombination was a function of laser fluence