Biography of Leann L Birch, PhD, 25 June 1946 – 26 May 2019

On 26 May, 2019, the nutrition community lost a visionary ambassador, trusted advisor, and cherished mentor. Leann Birch was a pioneer in bringing a developmental psychology perspective to the study of children\u27s nutrition as a means to respond to real-world questions raised by parents. Leann Elsie Traub was born in Owosso, Michigan 25 June, 1946. She grew up primarily in Southern California and received a bachelor\u27s degree in psychology from California State University, Long Beach, in 1971. She completed her graduate studies at the University of Michigan where she received a master\u27s degree in 1973 and a doctorate in 1975, both in psychology. She subsequently held faculty appointments reflecting affiliations with nutrition as well as human development at the University of Illinois, Urbana-Champaign (1976–1992), the Pennsylvania State University (1992–2014), and the University of Georgia (2014–2019). Over this time, Leann was a prolific scientist, publishing \u3e250 publications (with \u3e51,000 citations) and receiving \u3e$30 million in federal research funding. The public health impact and reach of Leann\u27s work is profound. References to her work can be found everywhere: federal dietary guidance, position statements from leading professional organizations, early-childhood education policies, anticipatory guidance given in the pediatrician\u27s office, and popular books on feeding children

Keck Spectra of Brown Dwarf Candidates and a Precise Determination of the Lithium Depletion Boundary in the Alpha Persei Open Cluster

We have identified twenty-seven candidate very low mass members of the relatively young Alpha Persei open cluster from a six square degree CCD imaging survey. Based on their I magnitudes and the nominal age and distance to the cluster, these objects should have masses less than 0.1 Msunif they are cluster members. We have subsequently obtained intermediate resolution spectra of seventeen of these objects using the Keck II telescope and LRIS spectrograph. We have also obtained near-IR photometry for many of the stars. Our primary goal was to determine the location of the "lithium depletion boundary" and hence to derive a precise age for the cluster. We detect lithium with equivalent widths greater than or equal to 0.4 \AA in five of the program objects. We have constructed a color-magnitude diagram for the faint end of the Alpha Persei main sequence. These data allow us to accurately determine the Alpha Persei single-star lithium depletion boundary at M(I$_C$) = 11.47, M(Bol) = 11.42, (R-I)$_{C0}$ = 2.12, spectral type M6.0. By reference to theoretical evolutionary models, this converts fairly directly into an age for the Alpha Persei cluster of 90 $\pm$ 10 Myr. At this age, the two faintest of our spectroscopically confirmed members should be sub-stellar (i.e., brown dwarfs) according to theoretical models.Comment: Accepted Ap

Psychoneuroimmunology: application to ocular diseases

Psychoneuroimmunology (PNI) is a relatively new discipline within the field of neuroscience which researches the relationship between emotional states, the central and peripheral nervous systems, and the endocrine and immune systems. Negative psychological states, such as stress, anxiety, and depression, may alter immune system regulation and modulation of peripheral cytokines. A plethora of PNI studies have shown that increased psychological stress and depression are associated with an alteration of immune functioning and worsened health outcomes for many conditions. To date, application of PNI methodology has not been reported for ocular diseases. This article provides an historical perspective on the origins of the rift between the emotional and spiritual from physical aspects of disease. A review of how stress is mediated through sympathetic adrenomedullary and hypothalamic pituitary axis activation with shifts in immunity is provided. The literature which supports spirituality in healing is presented. Finally, ocular diseases which would be most amenable to a PNI approach are discussed

Retinal ganglion cell functional plasticity and optic neuropathy: a comprehensive model

The clinical management of glaucoma and optic neuropathies has traditionally focused on stages of the diseases at which there are congruent losses of visual function and optic nerve tissue. Increasing clinical and experimental evidence suggests that the electrical activity of retinal ganglion cells, as measured by pattern electroretinogram (PERG), may be altered long before measurable changes in the thickness of the retinal nerve fiber layer. In addition, PERG alterations in early glaucoma may be either reversed by lowering the intraocular pressure or induced with head-down body posture. Here we apply the well-known concept of neural plasticity to model the reversible/inducible changes of retinal ganglion cell electrical activity during a critical period of dysfunction preceding death. Identification and characterization of this stage of modifiable retinal ganglion cell function represents both a rationale and a target for treatment to change the natural history of the disease

Physiologic significance of steady-state pattern electroretinogram losses in glaucoma: clues from simulation of abnormalities in normal subjects

To better understand pathophysiologic mechanisms underlying pattern electroretinogram (PERG) losses in glaucoma by simulating either retinal ganglion cell (RGC) dysfunction or RGC loss in normal subjects. The steady-state PERG has been recorded in 10 normal subjects (mean age: 31+/-8 y) according to the PERGLA paradigm by means of skin electrodes in response to horizontal gratings (1.7 cycles/degree, 99% contrast, 40 cd/m mean luminance, circular field size 25 degree diameter) alternating 16.28 times/seconds. Simulated RGC dysfunction has been obtained by reducing either contrast and mean luminance or blurring the visual stimulus. Simulated RGC loss has been obtained by reducing stimulus area. Outcome measures were PERG amplitude and phase obtained by discrete Fourier transform of PERG waveforms. Progressive PERG amplitude reductions spanning the entire dynamic range of PERG response could be obtained by progressively reducing stimulus contrast and luminance, blurring the stimulus, and reducing stimulus area. The same variations in stimulus conditions caused phase changes of disparate sign and magnitude. Phase advanced (latency shortened) by reducing stimulus contrast or blurring the stimulus; phase lagged (latency increased) by reducing stimulus luminance; phase remained constant by reducing stimulus area. PERG amplitude and phase are essentially uncoupled, implying that these measures reflect distinct aspects of RGC activity. On the basis of our results and known PERG physiology, we propose a model in which both RGC dendrites and RGC axons contribute to the PERG signal. PERG delays may represent an indication of synaptic dysfunction that is potentially reversible

Normative data for a user-friendly paradigm for pattern electroretinogram recording

To provide normative data for a user-friendly paradigm for the pattern electroretinogram (PERG) optimized for glaucoma screening (PERGLA). Prospective nonrandomized case series. Ninety-three normal subjects ranging in age between 22 and 85 years. A circular black-white grating of 25 degrees visual angle, reversing 16.28 times per second, was presented on a television monitor placed inside a Ganzfeld bowl. The PERG was recorded simultaneously from both eyes with undilated pupils by means of skin cup electrodes taped over the lower eyelids. Reference electrodes were taped on the ipsilateral temples. Electrophysiologic signals were conventionally amplified, filtered, and digitized. Six hundred artifact-free repetitions were averaged. The response component at the reversal frequency was isolated automatically by digital Fourier transforms and was expressed as a deviation from the age-corrected average. The procedure took approximately 4 minutes. Pattern electroretinogram amplitude ( micro V) and phase (pi rad); response variability (coefficient of variation [CV] = standard deviation [SD] / mean x 100) of amplitude and phase of 2 partial averages that build up the PERG waveform; amplitude ( micro V) of background noise waveform, obtained by multiplying alternate sweeps by +1 and -1; and interocular asymmetry (CV of amplitude and phase of the PERG of the 2 eyes). On average, the PERG has a signal-to-noise ratio of more than 13:1. The CVs of intrasession and intersession variabilities in amplitude and phase are lower than 10% and 2%, respectively, and do not depend on the operator. The CV of interocular asymmetries in amplitude and phase are 9.8+/-8.8% and 1.5+/-1.4%, respectively. The PERG amplitude and phase decrease with age. Residuals of linear regression lines have normal distribution, with an SD of 0.1 log units for amplitude and 0.019 log units for phase. Age-corrected confidence limits (P<0.05) are defined as +/-2 SD of residuals. The PERGLA paradigm yields responses as reliable as the best previously reported using standard protocols. The ease of execution and interpretation of results of PERGLA indicate a potential value for objective screening and follow-up of glaucoma

Restoration of retinal ganglion cell function in early glaucoma after intraocular pressure reduction: a pilot study

To investigate the changes of pattern electroretinogram (PERG) after intraocular pressure lowering in glaucoma patients and normal controls. Interventional retrospective cross-sectional study. Twenty-five patients (49 eyes) with ocular hypertension or glaucoma undergoing topical treatment to lower IOP served as a study group; 22 patients (44 eyes) with ocular hypertension or glaucoma observed without treatment served as a control group for treated glaucoma patients; 9 normal subjects (18 eyes) receiving a 250-mg acetazolamide tablet served as a second study group; and 17 normal subjects (34 eyes) from a previous study served as a second control group for treated normal subjects. Pattern electroretinograms were recorded simultaneously from both eyes using skin electrodes and automated analysis. Visual field (VF) analyses were performed with white-on-white standard automated perimetry (SAP). Intraocular pressure was measured with Goldmann applanation tonometry; central corneal thickness was measured with pachymetry. Pattern electroretinogram amplitude (microvolts), phase (pi rads), and test-retest variability (test 2-to-test 1 ratio, in decibels), SAP mean deviation (decibels), and IOP (millimeters of mercury). In 56% of right eyes and 21% of left eyes of the treated glaucoma subgroup, the PERG amplitude and/or phase improved beyond the 95% confidence intervals of the test-retest variability of the untreated glaucoma control group. Pattern electroretinogram improvement with IOP lowering occurred in both high- and low-tension glaucoma eyes. Eyes with severely impaired VFs showed little improvement in PERG; however, eyes of normal subjects treated with acetazolamide did not show significant PERG changes relative to the test-retest variability of normal controls. Retinal ganglion cell function can be at least partially restored after IOP reduction in glaucomatous eyes with early VF impairment

Adaptive changes of inner retina function in response to sustained pattern stimulation

We have characterized adaptive changes of inner retina function in response to sustained pattern stimulation in 32 normal subjects with an age range 23-77 years by measuring changes of the pattern electroretinogram (PERG) as a function of time. Contrast-reversal stimuli had square-wave profile in space and time, with peak spatial and temporal frequency and high contrast to maximize response amplitude. The PERG signal was sampled over 5min with a resolution of 15s. PERG signals were non-stationary, resulting in either progressive amplitude decline or even enhancement to a plateau, with a time course that could be well described by an exponential function with a time constant of 1-2min. Higher initial amplitudes were generally associated with amplitude decline, and lower initial amplitudes with enhancement. The delta amplitude (plateau minus initial) was a linear function of the initial amplitude. The magnitude of delta decreased with decreasing initial amplitude and inverted its sign for initial amplitudes about 1/3 lower than the maximum initial amplitude measured, but still about 3-4 times larger than the noise. Amplitude decline was generally associated with phase lag, whereas amplitude enhancement was associated with phase advance. Altogether, PERG generators appear to slowly adjust their gain in order to keep their sustained activity at an intermediate level that is rather independent of the level of activity at stimulus onset. This behavior is reminiscent of a buffering mechanism, where glial cells may play a primary role. An energy-budget model of neural-vascular-glial interaction is provided together with an equivalent electrical circuit that accounts for the results

Progressive loss of retinal ganglion cell function is hindered with IOP-lowering treatment in early glaucoma

To investigate progressive changes of retinal ganglion cell (RGC) function in glaucoma suspects before and after IOP-lowering treatment. The authors retrospectively analyzed pattern electroretinograms (PERG) recorded twice a year in 32 glaucoma suspects over at least 6 years. Fifteen patients (28 eyes in the study group) received IOP-lowering treatment at intermediate points during the follow-up, thereby generating a break point between the untreated period and the treated period. Seventeen patients (31 eyes in the control group) were not treated; a break point in the follow-up period was randomly assigned. To assess the effect of treatment, linear regression slopes of PERG amplitude were calculated for periods before and after the break point, and compared both within and between groups. Linear mixed models applied to raw PERG amplitudes recorded over the entire follow-up period were also calculated. Before the break point, slopes had a similar negative trend in both groups, whereas after the break point the slope became shallower in the treated group (P = 0.002). The linear mixed model revealed an interaction between groups, period relative to break point, and segment duration (P = 0.001). Both analyses agreed that after the break point, the rate of PERG amplitude decline slowed in treated eyes by 0.013-0.019 μV/year compared with the untreated eyes. Mean IOPs measured before and after break point were similar in control eyes (14.8 ± 3.20 vs. 14.8 ± 3.14 mm Hg) but different in treated eyes (16.84 ± 3.96 vs. 14.8 ± 3.24 mm Hg; P < 0.001). Progressive loss of RGC function in early glaucoma may be alleviated after IOP lowering, as measured by PERG