Successful treatment of a persistent rhino-cerebral mucormycosis in a pediatric patient with a debut of acute lymphoblastic leukemia Tratamiento exitoso de una mucormicosis rinocerebral persistente en un paciente pediátrico durante el debut de una leucemi

© 2015, Sociedad Chilena de Infectologia. All rights reserved.The fungi of the order Mucorales cause mucormycosis, which usually presents as an invasive fungal disease with rapid angioinvasion in immunocompromised patients. Rhinocerebral is the most common presentation. The lipid formulations of amphotericin B are used as primary treatment in invasive mucormycosis; the combined use of posaconazole could allow a reduction in the dose of amphotericin B improving tolerance and adherence to treatment. Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models. We present the case of a preschool patient that during the debut of acute lymphoblastic leukemia developed a rhinocerebral mucormycosis successfully responding to antifungal treatment with the combination of liposomal amphotericin and caspofungin

Noonan syndrome with multiple Giant cell lesions, management and treatment with surgery and interferon alpha-2a therapy: Case report

We report the case of a 14-year-old girl that was referred to the maxillo facial surgery unit at age 11 years because she exhibited swelling in the right side of her maxilla and right mandible. After a conservative surgery, she started with interferon alpha-2a to avoid recurrence. She has remained in treatment with successful results during her follow up. Considerable reduction of both maxilla and mandible lesions and bone fill have been documented. In addition, her clinical history and phenotype were suggestive of Noonan syndrome. She has short stature, broad and short neck; hypertelorism (increased distance between the eyes); downslanting palpebral fissures; sparse eyebrows and eyelashes; posteriorly rotated ears with fleshy lobes; follicular keratosis over the face, and developmental delay. Her karyotype was 46, XX. Molecular analysis of RAS/MAPK pathway genes showed a SOS1 amino acid substitution of arginine to lysine at position 552 (p.R552K). This case presents the infrequent condition of Noonan syndrome with multiple giant cell lesions (NS/MGCL) that would be the first patient as far as we know treated with surgery and interferon alpha-2a for her giant cell lesions

QUISTE FOLICULAR INFLAMATORIO. REVISIÓN BIBLIOGRÁFICA Y REPORTE DE TRES CASOS CLÍNICOS

El quiste folicular se ubica según la clasificación de la OMS como un quiste inflamatorio, siendo una patología poco frecuente. Se presenta en los niños entre los 5 a 12 años, es más frecuente en hombres y la zona anatómica más afectada es la región mandibular correspondiente a los premolares. La etiología, es inflamatoria ya que existe una progresión del proceso inflamatorio de los molares temporales tratados endodónticamente hacia el folículo del premolar.  El tratamiento de ésta patología varía desde la extracción del diente temporal hasta un tratamiento más invasivo como la enucleación del quiste. La selección del tratamiento depende de diferentes factores como la edad del paciente, tamaño de la lesión, compromiso de estructuras adyacentes, ubicación del diente retenido etc. Generalmente el pronóstico es bueno. Se presenta una revisión de la literatura sobre el quiste folicular inflamatorio, y tres casos pediátricos. Se revisarán las características clínicas, imagenológicas, posibles diagnósticos diferenciales y el tratamiento. Palabras Clave: Quiste Folicular InflamatorioSummaryThe follicular cyst was classified by the OMS in 1992 as an inflammatory cyst. The prevalence is poor and may be encountered in patients between 5 and 12 years old. There is a male predilection and a higher prevalence in the mandibular premolars. The pathogenesis is a result of the progression from a periapical inflammation from an overlying primary tooth that has been pulpotomized to the premolar follicle. The treatment for the follicular cyst varies from the extraction of the primary tooth to enucleation of the cyst. The selection of the treatment depends on the age of the patient, extension of the cyst, the compromise of the adjacent structures, location of the impacted tooth etc. Generally the prognosis is excellent. A review of the literature about the follicular cyst and three pediatric cases will be presented. The clinical and radiographic features, differential diagnosis and treatment will be discussed.Key Words: Follicular Cyst, Inflammatory Cyst

Histiocitosis de células de Langerhans localizada en hueso malar. Presentación de un caso

ResumenLa histiocitosis de células de Langerhans localizada (HCLL), conocida como granuloma eosinófilo, representa entre el 50 y el 60% de todos los casos de histiocitosis de células de Langerhans. El tratamiento clásico para la HCLL ha sido el curetaje o la resección de las lesiones óseas. Hay publicaciones de casos tratados con inyección intralesional de corticosteroides, combinado con curetaje.Se presenta un caso clínico de un paciente de tres años de edad con diagnóstico de HCLL que compromete en su extensión el hueso malar, tratado con infiltraciones de corticosteroides y posterior curetaje de la lesión. A un año de realizado el tratamiento, el paciente se encuentra asintomático y con una regeneración ósea del hueso malar, evidenciable en la tomografía axial computarizada.AbstractLocalized Langerhans cell histiocytosis (LLCH), also known as eosinophilic granuloma, represents 50 to 60% of all cases of Langerhans cell histiocytosis. The standard treatment for LLCH has been lesion curettage or resection. Cases treated with intralesional corticosteroid injections combined with curettage have been described.We report the case of a three-year-old patient diagnosed of LLCH with extensive zygomatic bone involvement, who was treated with corticosteroid infiltrations and subsequent curettage of the lesion. One year after treatment, the patient is asymptomatic with zygomatic reossification evidenced on computed tomography