Aditivacion de resinas epoxi mediante complejos poliméricos homo y heterometálicos con 1,3,5-triaza-7-fosfaadamantanofosfina (PTA) y 3,7-dimetil-1,3,7-triaza-5-phosphabiciclo[3.3.1]nonane (dmoPTA)

Publication number: ES2627009 A1 (26.07.2017) Also published as: ES2627009 B2 (22.01.2018) Application number: P201600099 (26.01.2016)La presente invención se relaciona con el uso de polímeros homo y heterometálicos con el ligando 1,3,5-triaza-7-fosfaadamantanofosfina (PTA) y 3,7-dimetil-1,3,7-triaza-5-phosphabiciclo[3.3.1]nonane) (dmoPTA), como aditivos de resinas epoxídicas. Estos aditivos previa disolución o suspensión mejoran y modifican las propiedades de las resinas confiriéndoles nuevas propiedades como color, conductividad eléctrica y magnética, resistencia térmica y al fuego, flexibilidad, distinto tiempo de curado, entre otras propiedades.Universidad de Almerí

New achievements on C-C bond formation in water catalyzed by metal complexes

The C-C coupling is the best strategy to obtain new organic molecules and building blocks from economical and abundant small molecules. Traditionally these reactions are accomplished in organic solvents, which are often dried before use as water molecules can react quickly with both the catalyst or the intermediate of the reactions, blocking the catalytic cycle. Nevertheless, the efforts of the researchers are providing new synthetic procedures in water that can substitute some of those, previously developed, "dry reactions". In the last years, really useful processes to obtain C-C bonds in water were proposed. These reactions usually are catalysed with 4d-metals but also examples with metals of the first transition row were proposed. This review aims to summarize and order by types the C-C coupling catalytic reactions in water published during the last five years. The abundance of reactions and the significance of the published results shows that a long way is needed to achieve a good knowledge of catalytic C-C coupling reactions in water. Nevertheless, accomplish this objective can provide significant and valuable synthetic processes, more economical, cleaner, more selective, therefore friendlier and more respectful with nature. (C )2021 Elsevier B.V. All rights reserved.Authors thank to the University of Almeria for the project PPUENTE2020/011 and the Junta de Andalucia for funding research PAI team FQM-317

New Findings in Metal Complexes with Antiproliferative Activity Containing 1,3,5-Triaza-7-phosphaadamantane (PTA) and Derivative Ligands

This minireview summarizes some of the most significant findings published in the last years on metal complexes containing PTA and PTA derivatives ligands such as dmoPTA, with antiproliferative activity [PTA = 1,3,5-triaza-7-phospha- adamantane; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[ 3.3.1]nonane (dmoPTA)]. Comments on other biological properties of the complexes are also included

New achievements on C-C bond formation in water catalyzed by metal complexes.

The C–C coupling is the best strategy to obtain new organic molecules and building blocks from economical and abundant small molecules. Traditionally these reactions are accomplished in organic solvents, which are often dried before use as water molecules can react quickly with both the catalyst or the intermediate of the reactions, blocking the catalytic cycle. Nevertheless, the efforts of the researchers are providing new synthetic procedures in water that can substitute some of those, previously developed, ‘‘dry reactions”. In the last years, really useful processes to obtain C–C bonds in water were proposed. These reactions usually are catalysed with 4d-metals but also examples with metals of the first transition row were proposed. This review aims to summarize and order by types the C–C coupling catalytic reactions in water published during the last five years. The abundance of reactions and the significance of the published results shows that a long way is needed to achieve a good knowledge of catalytic C–C coupling reactions in water. Nevertheless, accomplish this objective can provide significant and valuable synthetic processes, more economical, cleaner, more selective, therefore friendlier and more respectful with nature

Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity.

[{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-N,N’-CuCl}2-μ-Cl-μ- OCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2- N,N’-NiCl}2-μ-Cl-μ-OH](CF3SO3)2 (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI50 values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated

Impact of operatoŕs experience on peri-procedural outcomes with Watchman FLX: Insights from the FLX-SPA registry

Background: The Watchman FLX is a device upgrade of the Watchman 2.5 that incorporates several design enhancements intended to simplify left atrial appendage occlusion (LAAO) and improve procedural outcomes. This study compares peri-procedural results of LAAO with Watchman FLX (Boston Scientific, Marlborough, Massachusetts) in centers with varying degrees of experience with the Watchman 2.5 and Watchman FLX. Methods: Prospective, multicenter, 'real-world' registry including consecutive patients undergoing LAAO with the Watchman FLX at 26 Spanish sites (FLX-SPA registry). Implanting centers were classified according to the center's prior experience with the Watchman 2.5. A further division of centers according to whether or not they had performed ≤ 10 or > 10Watchman FLX implants was prespecified at the beginning of the study. Procedural outcomes of institutions stratified according to their experience with the Watchman 2.5 and FLX devices were compared. Results: 359 patients [mean age 75.5 (SD8.1), CHA2DS2-VASc 4.4 (SD1.4), HAS-BLED 3.8(SD0.9)] were included. Global success rate was 98.6%, successful LAAO with the first selected device size was achieved in 95.5% patients and the device was implanted at first attempt in 78.6% cases. There were only 9(2.5%) major peri-procedural complications. No differences in efficacy or safety results according to the centeŕs previous experience with Watchman 2.5 and procedural volume with Watchman FLX existed. Conclusions: The Watchman FLX attains high procedural success rates with complete LAA sealing in unselected, real-world patients, along with a low incidence of peri-procedural complications, regardless of operatoŕs experience with its previous device iteration or the number of Watchman FLX devices implanted