Sheathing and Pay Techniques in the Boa Vista 1 Ship (Lisbon, Portugal)

Between September 2012 and February 2013, archaeological excavations carried out in the riverside area of Lisbon (Portugal) revealed the remains of two wooden ships: Boa Vista 1 (BV1) and Boa Vista 2 (BV2), both dating from the late seventeenth or early eighteenth century. BV1 ship consists of scattered hull timbers which were damaged and out of their original positions. Some of the ship’s hull features are common in the Mediterranean like a composite keel with butt joints and hook scarfs in the connection between floors and futtocks, while others are well-known Iberian shipbuilding features like the transition between the keel and the sternpost being made through a single piece, the heel. A unique feature was a layer of animal hair between the sheathing and the hull planking. This paper focuses mainly on the study of wooden sheathing, including but not limited to the analysis of its conventional “architectural signatures”. The latest results concerning animal hair identification will also be presented and discussed, showing the added value of multidisciplinary approaches in archaeology.info:eu-repo/semantics/publishedVersio

A probable early 16th century colonial shipwreck in the Portuguese coast

UIDB/04666/2020 UIDP/04666/2020The Ria de Aveiro F site was discovered during preventive archaeological works carried out in the scope of the 2002 expansion of Aveiro’s harbour into the Ria de Aveiro, a lagoon system located in northern Portugal which played a great role in the salt trade of the Early Modern period. Despite the global destruction of the context caused by the dredging works, several well preserved structural elements were recovered. They belonged to two ships, a carvel-built one and a clinker-built one. The former features several construction characteristics that are common in the Mediterranean. The latter possibly corresponds to a small support boat. Beside the structural findings, several rigging elements wooden and rope artifacts, some pottery shards, ballast stones and a limestone cannonball were also recovered. The global study of the findings allowed to assign these remains to a chronology around the first half of the 16th century. Wood identification analysis were recently carried out; the results indicate the use of tropical, South American species in the construction of the clinker-built vessel. This data allows us to suggest that this site may belong to an initial phase of the relationship between the Americas and the Iberian Peninsula.publishersversionpublishe

Evaluation of a deep learning approach for predicting the fraction of transpirable soil water in vineyards

As agriculture has an increasing impact on the environment, new techniques can help meet future food needs while maintaining or reducing the environmental footprint. Those techniques must incorporate a range of sensing, communication, and data analysis technologies to make informed management decisions, such as those related to the use of water, fertilizer, pesticides, seeds, fuel, labor, etc., to help increase crop production and reduce water and nutrient losses, as well as negative environmental impacts. In this study, a Bidirectional Long Short-Term Memory (BiLSTM) model was trained on real data from Internet of Things sensors in a vineyard located in the Douro wine-growing region, from 2018–2021, to evaluate the ability of this model to predict the Fraction of Transpirable Soil Water (FTSW). The model uses historical data, including reference evapotranspiration, relative humidity, vapor pressure deficit, and rainfall, and outputs the FTSW for periods of one, three, five, and seven days. The model achieved an RMSE between 8.3% and 16.6% and an R2-score between 0.75 and 0.93. The model was validated on an independent dataset collected in 2002–2004 from a different vineyard located in the Lisbon wine-growing region, Portugal, and achieved an R2-score of 87% and an RMSE of 10.36%. Finally, the performance of the FTSW in the vineyard prediction model was compared with that of the Random Forest model, support vector regression, and linear regression. The results showed that BiLSTM performed better than the RF model on the unseen data, and the BiLSTM model can be considered a suitable model for the accurate prediction of the FTSW.info:eu-repo/semantics/publishedVersio

The protist Trichomonas vaginalis harbors multiple lineages of transcriptionally active Mutator-like elements

<p>Abstract</p> <p>Background</p> <p>For three decades the <it>Mutator </it>system was thought to be exclusive of plants, until the first homolog representatives were characterized in fungi and in early-diverging amoebas earlier in this decade.</p> <p>Results</p> <p>Here, we describe and characterize four families of <it>Mutator</it>-like elements in a new eukaryotic group, the Parabasalids. These <b><it>T</it></b><it>richomonas </it><b><it>v</it></b><it>aginalis </it><it><b>Mu</b>tator- <b>l</b>ike </it><it><b>e</b>lements</it>, or <it>TvMULEs</it>, are active in <it>T. vaginalis </it>and patchily distributed among 12 trichomonad species and isolates. Despite their relatively distinctive amino acid composition, the inclusion of the repeats <it>TvMULE1</it>, <it>TvMULE2</it>, <it>TvMULE3 </it>and <it>TvMULE4 </it>into the <it>Mutator </it>superfamily is justified by sequence, structural and phylogenetic analyses. In addition, we identified three new <it>TvMULE</it>-related sequences in the genome sequence of <it>Candida albicans</it>. While <it>TvMULE1 </it>is a member of the <it>MuDR </it>clade, predominantly from plants, the other three <it>TvMULEs</it>, together with the <it>C. albicans </it>elements, represent a new and quite distinct <it>Mutator </it>lineage, which we named <it>TvCaMULEs</it>. The finding of <it>TvMULE1 </it>sequence inserted into other putative repeat suggests the occurrence a novel TE family not yet described.</p> <p>Conclusion</p> <p>These findings expand the taxonomic distribution and the range of functional motif of <it>MULEs </it>among eukaryotes. The characterization of the dynamics of <it>TvMULEs </it>and other transposons in this organism is of particular interest because it is atypical for an asexual species to have such an extreme level of TE activity; this genetic landscape makes an interesting case study for causes and consequences of such activity. Finally, the extreme repetitiveness of the <it>T. vaginalis </it>genome and the remarkable degree of sequence identity within its repeat families highlights this species as an ideal system to characterize new transposable elements.</p

Avaliação e tratamento do doente com acne – Parte I: Epidemiologia, etiopatogenia, clínica, classificação, impacto psicossocial, mitos e realidades, diagnóstico diferencial e estudos complementares

O Portuguese Acne Advisory Board (PAAB), grupo de dermatologistas portugueses que, à semelhança de grupos congéneres internacionais, tem dedicado particular atenção à definição de linhas de orientação para o tratamento da acne, pretende que o presente documento constitua uma ferramenta útil na abordagem dos doentes com esta patologia. Elaborou-se um dossier, para educação médica contínua, subdividido em 2 partes: Parte I – etiopatogenia e clínica; Parte II – abordagem terapêutica. Nesta Parte I, revêem-se os principais aspectos da clínica e da fisiopatogenia da acne à luz dos conhecimentos actuais. Discute-se a importância do impacto psicológico e social desta entidade e analisam-se os principais mitos e realidades com ela relacionados. Descrevem-se, sucintamente, as patologias mais relevantes no diagnóstico diferencial das lesões de acne. Enumeram-se as indicações para estudo hormonal, bem como os exames a efectuar nos doentes com esta patologia. The Portuguese Acne Advisory Board (PAAB), a group of Portuguese dermatologists with a special interest in acne, develop, as other international groups in this field, consensus recommendations for the treatment of acne. Overall, the goal is to provide a practice guideline to all physicians dealing with this entity. The continuing medical education dossier was divided in two parts: Part I – etiopathogeny and clinical features; Part II – therapy. This Part I reviews acne pathophysiology, clinical aspects, psychological and social impact and several myths surrounding this disease. Some other entities relevant for the differential diagnosis are described. The need of hormonal evaluation is also discusse

Avaliação e tratamento do doente com acne - Parte II: tratamento tópico, sistémico e cirúrgico, tratamento da acne na grávida, algoritmo terapêutico

O Portuguese Acne Advisory Board (PAAB), grupo de dermatologistas portugueses que, à semelhança de grupos congéneres internacionais, tem dedicado particular atenção à definição de linhas de orientação para o tratamento da acne, pretende que o presente documento constitua uma ferramenta útil na abordagem dos doentes com esta patologia. Elaborou-se um dossier, para educação médica contínua, subdividido em 2 partes: Parte I – etiopatogenia e clínica; Parte II – abordagem terapêutica. Nesta Parte II discute-se a abordagem terapêutica – tópica e sistémica – em cada forma clínica de acne, dando particular ênfase aos retinóides e aos antimicrobianos, e salientam-se as estratégias a adoptar para limitar a crescente resistência bacteriana aos antibióticos. Referem-se as indicações específicas para terapêutica hormonal e analisam-se as particularidades do tratamento da acne na grávida e lactante. Descrevem-se algumas técnicas para correcção das cicatrizes da acne. Por último, publica-se um algoritmo que pretende ilustrar a classificação da acne e definir, para cada tipo clínico, a abordagem terapêutica consensualmente recomendada

Early modern reused ship timbers from Boqueirão do Duro, Lisbon, Portugal

Archaeological excavations conducted at the riverside area of Lisbon (Boqueirão do Duro, Santos) in 2016 revealed archaeological remains from the 18th to the 19th centuries, including the remains of a late 19th-century factory named Vulcano e Colares built on top of an ancient beach and later port.The waterfront archaeological contexts were wide-ranging. There were several timbers from a large ship dismantled on the beach, port structures that reused ship elements, and an assemblage of pre-shaped timbers. Among the dismantled elements were keels, keelsons, stems, floor timbers, futtocks, hull planks, wooden sheathing, and an uncommon find, three complete bilge pumps.Des fouilles archéologiques menées sur les rives du Tage à Lisbonne (Boqueirão do Duro, Santos) en 2016 ont révélé des vestiges archéologiques du xviiie au xixe siècles, y compris les vestiges d’une usine de la fin du xixe siècle nommée Vulcano e Colares, construite au sommet d’une ancienne plage qui deviendra plus tard un port.Les contextes archéologiques de la rive se révèlent très variés : plusieurs fragments de bois d’un grand navire démantelé sur la plage, des structures portuaires qui réutilisaient des éléments de navire et un assemblage de bois de charpente pré-équarri. Parmi les éléments démontés, on trouve des quilles, des carlingues, des étraves, des vaigres, des allonges, des fragments de bordé, des revêtements en bois et une découverte rare : trois pompes de cale complètes

Perfluorinated Alcohols at High Pressure: Experimental Liquid Density and Computer Simulations

The liquid density of five liquid 1H,1H-perfluorinated alcohols (CF3(CF2)n−1CH2OH n = 2, 3, 4, 5, 6) was measured as a function of pressure (0.1−70 MPa) and temperature (293.15−313.15 K). The corresponding isothermal compressibility and isobaric thermal expansivity coefficients were calculated from the experimental data. The results are compared with data from the literature for the equivalent hydrogenated alcohols. Atomistic molecular dynamics simulations were also performed, providing molecular-level insight into the experimental results, in particular about the H-bond network of the perfluorinated alcohols and the effect of pressure on the organization of the liquid

Stage at presentation of breast cancer in Luanda, Angola - a retrospective study

Background: It is expected that, by 2020, 15 million new cases of cancer will occur every year in the world, one million of them in Africa. Knowledge of cancer trends in African countries is far from adequate, and improvements in cancer prevention efforts are urgently needed. The aim of this study was to characterize breast cancer clinically and pathologically at presentation in Luanda, Angola; we additionally provide quality information that will be useful for breast cancer care planning in the country. Methods: Data on breast cancer cases were retrieved from the Angolan Institute of Cancer Control, from 2006 to 2014. For women diagnosed in 2009 (5-years of follow-up), demographic, clinical and pathological information, at presentation, was collected, namely age at diagnosis, parity, methods used for pathological diagnoses, tumor pathological characteristics, stage of disease and treatment. Descriptive statistics were performed. Results: The median age of women diagnosed with breast cancer in 2009 was 47 years old (range 25–89). The most frequent clinical presentation was breast swelling with axillary lymph nodes metastasis (44.9 %), followed by a mass larger than 5 cm (14.2 %) and lump (12.9 %). Invasive ductal carcinoma was the main histologic type (81.8 %). Only 10.1 % of cancer cases had a well differentiated histological grade. Cancers were diagnosed mostly at advanced stages (66.7 % in stage III and 11.1 % in stage IV). Discussion: In this study, breast cancer was diagnosed at a very advanced stage. Although it reports data from a single cancer center in Luanda, Angola it reinforces the need for early diagnosis and increasing awareness. According to the main challenges related to breast cancer diagnosis and treatment herein presented, we propose a realistic framework that would allow for the implementation of a breast cancer care program, built under a strong network based on cooperation, teaching, audit, good practices and the organization of health services. Conclusion: Angola needs urgently a program for early diagnosis of breast cancer.We thank Susana Santos for correction of the article in English language, and a Cancer Registry Staff from IACC, particularly Pedro Luis Hernandez Gonzalez, Paulo Ernesto Alves, Xacu Parica and Alberto Sivi Lutumba for their support in data acquisition. We also thank SEMED -Portugal in support for publication