Guest Editorial: Taking Mentoring Seriously

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66955/2/10.1177_00220345910700032001.pd

The Relationship Between Gingivitis and the Serum Antibodies to the Microbiota Associated With Periodontal Disease in Children With Down’s Syndrome

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141873/1/jper0626.pd

A Comparison of the Gingival Health of Children with Down Syndrome to Healthy Children Residing in an Institution

The purpose of this study was to compare the onset and severity of gingivitis in children with Down syndrome, when compared to a healthy control group of children. The subjects included 41 children with Down syndrome ages two to 14 years (mean age: 7.6 years) and 112 age-matched healthy controls. We assessed the gingival health of all subjects using the gingival inflammation (M-PMA) index and periodontal probing depth (PD). Children were divided into three age categories: <5 years (AD, 5 to <10 years (AID, and 10 to <17 years (AIII). Supragingival plaque was measured using the Oral Hygiene Index (OHI) and the subjects were screened with the BANA test (Perioscan-Oral-B). Measurement of the M-PMA index in the healthy children showed an age-related increase (F = 10.369. p<0.001), and the M-PMA index at the younger age group <5 year (AD was significantly lower than that for the other two age groups AII or AIII (p<0.005, p<0.001). In contrast, the M-PMA index values at AI and AIII in the subjects with Down syndrome were significantly higher than those for healthy children (p<0.001, p<0.001). Both groups had an age-related increase in PD (F=3.388, p<0.05 & F= 10.806, p<0.001). and PD at AIII was significantly higher than that at AI in both groups (p<0.01, p<0.001). The children with Down syndrome showed an age-related increase in the BANA test score (F=3.452, p<0.05), and the BANA test score at AIII was significantly higher than that at AI (p<0.02). The BANA test score in the healthy children was not age-related but was significantly higher than that in the children with Down syndrome (p<0.02, p<0.05).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72264/1/j.1754-4505.2006.tb01504.x.pd

The Expression of the Epithelial Blood-group Substances: Normal and Malignant Tissues

The blood-group isoantigens are macromolecules localized to the plasma membranes of certain epithelial tissues.2,11-15 These substances are not detectable on the epithelium once it has undergone malignant transformation.2,9,13 Results of this investigation have demonstrated that the loss of detectability of the blood-group isoantigens does not appear to be related to a "masking" effect by an increase in surface sialic acid. Using fluorescein-labeled lectins specific for sugar subunits which are components of the blood-group oligosaccharide chain, it was found that the malignant cells and cells of the para basal layer of normal oral epithelium had high levels of N-acetyl-D-glucosamine (GlcNAC), the subterminal sugar residue of the blood-group chain. The basal cells of normal epithelium and a minority of the malignant cells demonstrated levels of D-galactose-N-acetyl-D-galactosamine, which are the most proximal blood-group sugar subunits, as well as subunits of other membrane antigens. Our results indicate that malignant cells seem to be capable of synthesizing the blood-group oligosaccharide chains to the same level as the normal cells of the para basal layer of stratified squamous epithelium. This level is just subjacent to the terminal D-galactose residue of the blood-group precursor chain. Increased or decreased differentiation characteristics of squamous cell carcinomas did not alter the level of blood-group synthesis. However, there may be a correlation between the level of synthesis of these antigens and the ability of the cells to demonstrate motility and to proliferate.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66719/2/10.1177_00220345800590112001.pd

The Relationship Between Gingivitis and Colonization by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in Children

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142121/1/jper0403.pd

Blood group substances as differentiation markers in human dento-gingival epithelium

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65594/1/j.1600-0765.1987.tb02054.x.pd

Occurrence of Porphyromonas gingivalis, Bacteroides forsythus, and Treponema denticola in Periodontally Healthy and Diseased Subjects as Determined by an ELISA Technique

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142036/1/jper0018.pd

Effect of Lyophilized Autologous Plasma on Periodontal Healing of Replanted Teeth

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142100/1/jper0568.pd

Humoral Immunity to Stress Proteins and Periodontal Disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141026/1/jper1185.pd

Measurement of immunoglobulin concentration in cell culture supernates by computer-assisted ELISA

The enzyme-linked immunosorbent assay (ELISA) is used extensively in immunologic research for obtaining quantitative estimates of immunoglobulin concentration in cell culture supernates. Through incorporation of a microcomputer for data acquisition, storage and rapid calculation of results, a substantial reduction in total assay time may be realized. Described here are a set of menu-driven programs written in Basic for the IBM-PC which provide advantages over existing software in simplicity, versatility and accuracy. Hardware requirements are minimal. These programs should encourage greater flexibility in terms of the size and complexity of experimental designs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25976/1/0000042.pd