How to remove the boundary in CFT - an operator algebraic procedure

The relation between two-dimensional conformal quantum field theories with and without a timelike boundary is explored.Comment: 18 pages, 2 figures. v2: more precise title, reference correcte

Cardiovascular disease and metabolic syndrome in health transition and evidence-based medicine: a perspective from Africa

The Cardiovascular Disease (CVD) pandemic worldwide presents a true challenge today with a high health burden that is only expected to rise. I address the causes and prevention of CVD, as well as CVD rehabilitation and physiology. As a member of the American Heart Association and European Society of cardiology, I practice under the level of evidence and the strength of recommendation of particular treatment options, as outlined in the tables below

Radio emission from dark matter annihilation in the Large Magellanic Cloud

The Large Magellanic Cloud, at only 50 kpc away from us and known to be dark matter dominated, is clearly an interesting place where to search for dark matter annihilation signals. In this paper, we estimate the synchrotron emission due to WIMP annihilation in the halo of the LMC at two radio frequencies, 1.4 and 4.8 GHz, and compare it to the observed emission, in order to impose constraints in the WIMP mass vs. annihilation cross section plane. We use available Faraday rotation data from background sources to estimate the magnitude of the magnetic field in different regions of the LMC's disc, where we calculate the radio signal due to dark matter annihilation. We account for the e+ e- energy losses due to synchrotron, Inverse Compton Scattering and bremsstrahlung, using the observed hydrogen and dust temperature distribution on the LMC to estimate their efficiency. The extensive use of observations, allied with conservative choices adopted in all the steps of the calculation, allow us to obtain very realistic constraints.Comment: 9 pages, 7 figure

On local boundary CFT and non-local CFT on the boundary

The holographic relation between local boundary conformal quantum field theories (BCFT) and their non-local boundary restrictions is reviewed, and non-vacuum BCFT's, whose existence was conjectured previously, are constructed.Comment: 16 pages. Contribution to "Rigorous Quantum Field Theory", Symposium in honour of J. Bros, Paris, July 2004. Based on joint work math-ph/0405067 with R. Long

Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells

Abstract: BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at 72 h (117 μM). Exposure of cells to BC-11, either pre-absorbed with a soluble preparation of the N-terminal fragment of urokinase-plasminogen activator (uPa), or in co-treatment with two different EGFR inhibitors, indicated that: (i) BC-11 acts via binding to the N-terminus of the enzyme where uPa- and EGF receptor-recognizing sites are present, thereby abrogating the growth-sustaining effect resulting from receptor binding; and (ii) the co-presence of the EGFR inhibitor PD153035 potentiates BC-11’s cytotoxicity. Exposure of cells to a higher concentration of BC-11 corresponding to its ED75 at 72 h (250 μM) caused additional impairment of mitochondrial activity, the production of reactive oxygen species and promotion of apoptosis. Therefore, BC-11 treatment appears to show potential for the development of this class of compounds in the prevention and/or therapy of “aggressive” breast carcinoma

Intestinal perforation after surgical treatment for incisional hernia. iatrogenic or idiopathic?

Intestinal perforation (IP) is a life-threatening gastroenterological condition requiring urgent surgical care, which may present itself as an uncommon complication following incisional hernia repair surgery, most often because of iatrogenic traumatism occurring during the procedure. However, we report a case where a spontaneous onset can be hypothesised. A 60-years-old patient underwent repair of an abdominal laparocele, through rectus abdominis muscle plasty, 5 years after development of an incisional hernia due to exploratory laparotomy for the treatment of acute appendicitis. Xipho-pubic scar was excised and umbilicus and supra-umbilical hernia sac dissected, a linear median incision was performed along the sub-umbilical linea alba, reaching preperitoneal plane to assess any intestinal loop adherence to the abdominal wall. After limited viscerolysis, abdominal wall defect was corrected by 'rectus abdominis muscle plasty' and umbilicus reconstruction by Santanelli technique. Postoperative course was uneventful until Day 29, with sudden onset of epigastric pain, fever and bulge. Sixty cubic centimeter pus was drained percutaneously and cavity was rinsed with a 50% H2O2 and H2O V-V solution until draining clear fluid. Symptoms recurred two days later, while during rinsing presented dyspnoea. X-Ray and CT scan diagnosed IP, and she underwent under emergency an exploratory laparotomy, leading to right hemicolectomy extended to last ileal loops and middle third of the transverse, right monolateral salpingo-ovariectomy and a temporary ileostomy by general surgeon. Twenty-three days later an ileostomy reversal surgery was performed and 8 days after she was discharged. At latest follow-up patient showed fair conditions, complaining abdominal pain and diarrhoea, attributable to the extensive intestinal resection. IP following incisional hernia repair, is reported as uncommon and early postoperative complication. In our case, the previous regular postoperative course with late onset lead us to hypothesise a possible idiopathic etiopathogenesis, because of a strangulation followed by gangrene and abscess formation, which might begin before the incisional hernia repair and unnoticed at the time surgery was performed

Industrial Aquaculture: History, Problems, Potential - Political Economic Review and Analysis of Socioecological Issues in Global Industrial Aquaculture Supply Chains

*This report highlights characteristics of global industrial aquaculture value chains. For example: Most producers are located in global South countries, but rely on input (e.g. feed, pest control agents) that are often in the hands of wealthy corporations in the EU and U.S. Global supply chains are buyer-driven, with massive grocery and retail food conglomerates based in the global North being the most powerful buyers. *Several key concerns related to feed are emphasized. For example: Social concerns of worker exploitation and forced labor to capture wild fish to feed farmed fish. Marine ecological concerns as wild fish stock suffers as a result of pressures to obtain "trash fish" as aquafeed. Concerns with impacts on terrestrial environment such as cutting down forests to cultivate soybean to feed farmed fish.*The prevalence of pests and diseases and the heavy use of antibiotics in industrial aquaculture operations is another concern. Intensive aquaculture also raises ethical concerns with regard to the welfare of the farmed aquatic animals.*The "displacement paradox" and the "Jevons paradox" in industrial aquaculture is explained.*The report cautions against the use of regulations that emphasize market mechanisms and new technologies as key solutions to industrial aquaculture with global value chains. It recommends instead the promotion of small-scale local supply chains, the production of species that are less reliant on intensive inputs, more in-tune with their ecological surroundings, and lower on the food chain (e.g. mussels, oysters)

The effect of non-Saccharomyces and Saccharomyces non-cerevisiae yeasts on ethanol and glycerol levels in wine

Non-Saccharomyces and Saccharomyces non-cerevisiae studies have increased in recent years due to an interest in uninoculated fermentations, consumer preferences, wine technology, and the effect of climate change on the chemical composition of grapes, juice, and wine. The use of these yeasts to reduce alcohol levels in wines has garnered the attention of researchers and winemakers alike. This review critically analyses recent studies concerning the impact of non-Saccharomyces and Saccharomyces non-cerevisiae on two important parameters in wine: ethanol and glycerol. The influence they have in sequential, co-fermentations, and solo fermentations on ethanol and glycerol content is examined. This review highlights the need for further studies concerning inoculum rates, aeration techniques (amount and flow rate), and the length of time before Saccharomyces cerevisiae sequential inoculation occurs. Challenges include the application of such sequential inoculations in commercial wineries during harvest time