68 research outputs found
A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116311/1/feb2s0014579307012264.pd
Transcription factor ZBP-89 is required for STAT1 constitutive expression
IFNγ is a pro-inflammatory cytokine that potentiates p53-independent apoptosis in a variety of cell types. STAT1 is the primary mediator of IFNγ action. ZBP-89 is a transcription factor that binds to the G/C-rich elements and mediates p53-independent apoptosis. In this study, site-directed mutagenesis revealed that a G-rich element from +171 to +179 within the first intron of the STAT1 gene is critical for optimal STAT1 promoter activity. Electrophoretic mobility shift assays and promoter analysis revealed that ZBP-89 binds directly to this STAT1 G-rich element along with Sp1 and Sp3. Reduction of ZBP-89 with siRNA attenuated both basal and IFNγ-induced STAT1 expression and subsequently diminished the activation of apoptotic markers, e.g. caspase-3 and PARP. Taken together, we conclude that ZBP-89 is required for constitutive STAT1 expression and in this way contributes to the ability of cells to be activated by IFNγ
Spiro compounds as IKZF2 degraders and their preparation, pharmaceutical compositions and use in the treatment of cancer
http://deepblue.lib.umich.edu/bitstream/2027.42/191181/2/WO 2023-183540 Al.pd
Piperidine-2,6-dione derivatives as cereblon-binding agents and their preparation
http://deepblue.lib.umich.edu/bitstream/2027.42/191180/2/WO 2023-183607 Al.pdfDescription of WO 2023-183607 Al.pdf : Published versio
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