Numerical Study on Nonlinear Semiactive Control of Steel-Concrete Hybrid Structures Using MR Dampers

Controlling the damage process, avoiding the global collapse, and increasing the seismic safety of the super high-rise building structures are of great significance to the casualties' reduction and seismic losses mitigation. In this paper, a semiactive control platform based on magnetorheological (MR) dampers comprising the Bouc-Wen model, the semi-active control law, and the shear wall damage criteria and steel damage material model is developed in LS-DYNA program, based on the data transferring between the main program and the control platform; it can realize the purpose of integrated modeling, analysis, and design of the nonlinear semi-active control system. The nonlinear seismic control effectiveness is verified by the numerical example of a 15-story steelconcrete hybrid structure; the results indicate that the control platform and the numerical method are stable and fast, the relative displacement, shear force, and damage of the steel-concrete structure are largely reduced using the optimal designed MR dampers, and the deformations and shear forces of the concrete tube and frame are better consorted by the control devices

Lack of Association of SULT1A1 R213H Polymorphism with Colorectal Cancer: A Meta-Analysis

BACKGROUND: A number of case-control studies were conducted to investigate the association of SULT1A1 R213H polymorphisms with colorectal cancer (CRC) in humans. But the results were not always consistent. We performed a meta-analysis to examine the association between the SULT1A1 R213H polymorphism and CRC. METHODS AND FINDINGS: Data were collected from the following electronic databases: PubMed, Elsevier Science Direct, Excerpta Medica Database, and Chinese Biomedical Literature Database, with the last report up to September 2010. A total of 12 studies including 3,549 cases and 5,610 controls based on the search criteria were involved in this meta-analysis. Overall, no significant association of this polymorphism with CRC was found (H versus R: OR = 1.04, 95%CI = 0.94-1.16, P = 0.46; HR+HH versus RR: OR = 1.01, 95%CI = 0.92-1.11, P = 0.81; HH versus RR+HR: OR = 1.01, 95%CI = 0.74-1.38, P = 0.95; HH versus RR: OR = 1.00, 95%CI = 0.77-1.31, P = 0.98; HR versus RR: OR = 1.01, 95%CI = 0.92-1.11, P = 0.86). In subgroup analysis, we also did not find any significant association in Cauasians (H versus R: OR = 1.02, 95%CI = 0.92-1.15, P = 0.68; HR+HH versus RR: OR = 0.99, 95%CI = 0.91-1.09, P = 0.90; HH versus RR+HR: OR = 1.01, 95%CI = 0.73-1.39, P = 0.97; HH versus RR: OR = 0.99, 95%CI = 0.75-1.31, P = 0.94; HR versus RR: OR = 0.99, 95%CI = 0.90-1.09, P = 0.85). The results were not materially altered after the studies which did not fulfill Hardy-Weinberg equilibrium were excluded (H versus R: OR = 1.06, 95%CI = 0.95-1.19, P = 0.31; HR+HH versus RR: OR = 1.03, 95%CI = 0.93-1.13, P = 0.56; HH versus RR+HR: OR = 1.10, 95%CI = 0.78-1.56, P = 0.57; HH versus RR: OR = 1.09, 95%CI = 0.83-1.44, P = 0.53; HR versus RR: OR = 1.02, 95%CI = 0.92-1.13, P = 0.75). CONCLUSION: This meta-analysis demonstrates that there is no association between the SULT1A1 R213H polymorphism and CRC

Automatic DNN architecture design using CPSOTJUTT for power system inspection

Abstract To quickly and accurately automatically design more high-precision deep neural network models (DNNs), this paper proposes an automatic DNN architecture design ensemble model based on consensus particle swarm optimization-assisted trajectory unified and TRUST-TECH (CPSOTJUTT), called CPSOTJUTT-EM. The proposed model is a three-layer model, and its core is a three-stage method for addressing the sensitivity of the local solver to the initial point and enabling fast and robust training DNN, effectively avoiding missing high-quality DNN models in the process of automatic DNN architecture design. CPSOTJUTT has the following advantages: (1) high-quality local optimal solutions (LOSs) and (2) robust convergence against random initialization. CPSOTJUTT-EM consists of the bottom layer: stable and fast design high-quality DNN architectures, the middle layer: exploration for a diverse set of optimal DNN classification engines, and the top layer: ensemble model for higher performance. This paper tests the performance of CPSOTJUTT-EM on public datasets and three self-made power system inspection datasets. Experimental results show that the CPSOTJUTT-EM has excellent performance in automatic DNN architecture design, DNN model optimization. And the CPSOTJUTT-EM can automatically design high-quality DNN ensemble models, laying a solid foundation for the application of DNN in other fields

Numerical Study on Nonlinear Semiactive Control of Steel-Concrete Hybrid Structures Using MR Dampers

Controlling the damage process, avoiding the global collapse, and increasing the seismic safety of the super high-rise building structures are of great significance to the casualties’ reduction and seismic losses mitigation. In this paper, a semiactive control platform based on magnetorheological (MR) dampers comprising the Bouc-Wen model, the semi-active control law, and the shear wall damage criteria and steel damage material model is developed in LS-DYNA program, based on the data transferring between the main program and the control platform; it can realize the purpose of integrated modeling, analysis, and design of the nonlinear semi-active control system. The nonlinear seismic control effectiveness is verified by the numerical example of a 15-story steel-concrete hybrid structure; the results indicate that the control platform and the numerical method are stable and fast, the relative displacement, shear force, and damage of the steel-concrete structure are largely reduced using the optimal designed MR dampers, and the deformations and shear forces of the concrete tube and frame are better consorted by the control devices

Fast Preparation of Porous MnO/C Microspheres as Anode Materials for Lithium-Ion Batteries

Porous MnO/C microspheres have been successfully fabricated by a fast co-precipitation method in a T-shaped microchannel reactor. The structures, compositions, and electrochemical performances of the obtained MnO/C microspheres are characterized by X-ray diffraction, field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (HRTEM), Brunauer–Emmett–Teller analysis, charge-discharge testing, cyclic voltammograms, and electrochemical impedance spectra. Experimental results reveal that the as-prepared MnO/C, with a specific surface area of 96.66 m2·g−1 and average pore size of 24.37 nm, exhibits excellent electrochemical performance, with a discharge capacity of 655.4 mAh·g−1 after cycling 50 times at 1 C and capacities of 808.3, 743.7, 642.6, 450.1, and 803.1 mAh·g−1 at 0.2, 0.5, 1, 2, and 0.2 C, respectively. Moreover, the controlled method of using a microchannel reactor, which can produce larger specific surface area porous MnO/C with improved cycling performance by shortening lithium-ion diffusion distances, can be easily applied in real production on a large scale

Neuropeptide Substance P Improves Osteoblastic and Angiogenic Differentiation Capacity of Bone Marrow Stem Cells In Vitro

Our previous work showed that implanting a sensory nerve or vascular bundle when constructing vascularized and neurotized bone could promote bone osteogenesis in tissue engineering. This phenomenon could be explained by the regulatory function of neuropeptides. Neuropeptide substance P (SP) has been demonstrated to contribute to bone growth by stimulating the proliferation and differentiation of bone marrow stem cells (BMSCs). However, there have been no prior studies on the association between Wnt signaling and the mechanism of SP in the context of BMSC differentiation. Our results have shown that SP could enhance the differentiation of BMSCs by activating gene and protein expression via the Wnt pathway and by translocating β-catenin, which can be inhibited by Wnt signaling blocker treatment or by the NK-1 antagonist. SP could also increase the growth factor level of bone morphogenetic protein-2 (BMP-2). Additionally, SP could enhance the migration ability of BMSCs, and the promotion of vascular endothelial growth factor (VEGF) expression by SP has been studied. In conclusion, SP could induce osteoblastic differentiation via the Wnt pathway and promote the angiogenic ability of BMSCs. These results indicate that a vascularized and neurotized tissue-engineered construct could be feasible for use in bone tissue engineering strategies

Identification of the Related Substances in Ampicillin Capsule by Rapid Resolution Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry

Rapid Resolution Liquid Chromatography coupled with Electrospray Ionization Tandem Mass Spectrometry (RRLC-ESI-MSn) was used to separate and identify related substances in ampicillin capsule. The fragmentation behaviors of related substances were used to identify their chemical structures. Finally, a total of 13 related substances in ampicillin capsule were identified, including four identified components for the first time and three groups of isomers on the basis of the exact mass, fragmentation behaviors, retention time, and chemical structures in the literature. This study avoided time-consuming and complex chemosynthesis of related substances of ampicillin and the results could be useful for the quality control of ampicillin capsule to guarantee its safety in clinic. In the meantime, it provided a good example for the rapid identification of chemical structures of related substances of drugs

Expression analysis of correlative regulatory factors of anthocyanin in ‘Cuihongli’ and ‘Qiangcuili’

MYB10, bHLH and WD40 are correlative regulatory factors of anthocyanin. In this paper, the expression of MYB10, bHLH and WD40 in the peel and the pulp of two plum cultivars were analyzed with the materials of ‘Cuihongli’ and ‘Qiangcuili’. The results showed that, with the development of the fruit of ‘Cuihongli’, the expression of MYB10 in the peel was downregulated firstly then upregulated, and the expression of MYB10 was not detected in the flesh of ‘Cuihongli’s pulp and the peel and the pulp of the ‘Qiangcuili’. The expression of bHLH and WD40 showed that the they had no significant correlation with the accumulation of anthocyanin in the two cultivars. It is suggested that the deletion of MYB10 gene expression result in the lack of anthocyanin in the flesh of ‘Qiangcuili’