CXCR4-targeted and MMP-responsive iron oxide nanoparticles for enhanced magnetic resonance imaging

MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity. In this study, two sets of iron oxide nanoparticles (IONPs) were synthesized that were designed to selectively undergo copper-free click conjugation upon sensing of matrix metalloproteinase (MMP) enzymes, thereby leading to a self-assembled superparamagnetic nanocluster network with T2 signal enhancement properties. For this purpose, IONPs with bioorthogonal azide and alkyne surfaces masked by polyethylene glycol (PEG) layers tethered to CXCR4-targeted peptide ligands were synthesized and characterized. The IONPs were tested in vitro and T2 signal enhancements of around 160 % were measured when the IONPs were incubated with cells expressing MMP2/9 and CXCR4. Simultaneous systemic administration of the bioorthogonal IONPs in tumor-bearing mice demonstrated the signal-enhancing ability of these ‘smart’ self-assembling nanomaterials

Fidelity, dynamic structure factor, and susceptibility in critical phenomena

Motivated by the growing importance of fidelity in quantum critical phenomena, we establish a general relation between fidelity and structure factor of the driving term in a Hamiltonian through a newly introduced concept: fidelity susceptibility. Our discovery, as shown by some examples, facilitates the evaluation of fidelity in terms of susceptibility using well developed techniques such as density matrix renormalization group for the ground state, or Monte Carlo simulations for the states in thermal equilibrium.Comment: 4 pages, 2 figures, final version accepted by PR

Tomographic measurements on superconducting qubit states

We propose an approach to reconstruct any superconducting charge qubit state by using quantum state tomography. This procedure requires a series of measurements on a large enough number of identically prepared copies of the quantum system. The experimental feasibility of this procedure is explained and the time scales for different quantum operations are estimated according to experimentally accessible parameters. Based on the state tomography, we also investigate the possibility of the process tomography.Comment: 12 pages, 4 figure

Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus.

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Reuse of design pattern measurements for health data

Research using health data is challenged by its heterogeneous nature, description and storage. The COVID-19 outbreak made clear that rapid analysis of observations such as clinical measurements across a large number of healthcare providers can have enormous health benefits. This has brought into focus the need for a common model of quantitative health data that enables data exchange and federated computational analysis. The application of ontologies, Semantic Web technologies and the FAIR principles is an approach used by different life science research projects, such as the European Joint Programme on Rare Diseases, to make data and metadata machine readable and thereby reduce the barriers for data sharing and analytics and harness health data for discovery. Here, we show the reuse of a pattern for measurements to model diverse health data, to demonstrate and raise visibility of the usefulness of this pattern for biomedical research