Research on Water Pollution Control Based on STM32 Intelligent Vehicle

In order to solve the high cost and low efficiency of different degrees of pollution control of natural water resources in China at this stage, photocatalytic water purification technology is adopted to reduce the cost of water pollution treatment and improve the treatment efficiency, and an intelligent vehicle equipped with photocatalytic materials is proposed, which is equipped with industrial cameras, communication positioning modules and sensors, and realizes dynamic planning of navigation routes by improving ant colony algorithms, computer vision recognition, ultrasonic obstacle avoidance, and realizes photocatalytic fixed-point purification. Predict advanced photoelectric catalytic performance based on density functional theory and machine learning, solve the problem of BiVO4 photo corrosion and instability, and achieve efficient water purification at low cost

High sensitivity HI image of diffuse gas and new tidal features in M51 observed by FAST

We observed the classical interacting galaxy M51 with FAST and obtain high sensitivity HI image with column density down to 3.8 $\times$ 10$^{18}$ cm$^{-2}$. In the image we can see a diffuse extended envelope around the system and several new tidal features. We also get a deeper look at M51b's probable gas, which has an approximated velocity range of 560 to 740 km s$^{-1}$ and a flux of 7.5 Jy km s$^{-1}$. Compared to the VLA image, we observe more complete structures of the Southeast Tail, Northeast Cloud and Northwest Plume, as well as new features of the Northwest Cloud and Southwest Plume. M51's most prominent tidal feature, the Southeast Tail, looks very long and broad, in addition with two small detached clouds at the periphery. Due to the presence of optical and simulated counterparts, the Northwest cloud appears to be the tail of M51a, while the Northwest Plume is more likely a tidal tail of M51b. The large mass of the Northwest Plume suggests that M51b may have been as gas-rich as M51a before the interaction. In addition, the formation process of the Northeast Cloud and Southwest Plume is obscured by the lack of optical and simulated counterparts. These novel tidal features, together with M51b's probable gas, will inspire future simulations and provide a deeper understanding of the evolution of this interacting system.Comment: 11 pages, 9 figures, accepted for publication in MNRA

Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction

Mild cognitive impairment (MCI) occurs during the pre-dementia stage of Alzheimer’s disease (AD) and is characterized by a decline in cognitive abilities that frequently represents a transition between normal cognition and AD dementia. Its pathogenesis is not well understood. Here, we demonstrate the direct consequences and potential mechanisms of oxidative stress, mitochondrial dynamic and functional defects in MCI-derived mitochondria. Using cytoplasmic hybrid (cybrid) cell model in which mitochondria from MCI or age-matched non-MCI subjects were incorporated into a human neuronal cell line depleted of endogenous mitochondrial DNA, we evaluated the mitochondrial dynamics and functions, as well as the role of oxidative stress in the resultant cybrid lines. We demonstrated increased expression levels of mitofusin 2 (Mfn2) is markedly induced by oxidative stress in MCI-derived mitochondria along with aberrant mitochondrial functions. Inhibition of oxidative stress rescues MCI-impaired mitochondrial fusion/fission balance as shown by the suppression of Mfn2 expression, attenuation of abnormal mitochondrial morphology and distribution, and improvement in mitochondrial function. Furthermore, blockade of MCI related stress-mediated activation of extracellular signal-regulated kinase (ERK) signaling not only attenuates aberrant mitochondrial morphology and function but also restores mitochondrial fission and fusion balance, in particular inhibition of overexpressed Mfn2. Our results provide new insights into the role of the oxidative stress-ERK-Mfn2 signal axis in MCI-related mitochondrial abnormalities, indicating that the MCI phase may be targetable for the development new therapeutic approaches that improve mitochondrial function in age-related neurodegeneration

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

Mitochondrial dysfunction is an early pathological feature of Alzheimer’s disease (AD). The underlying mechanisms and strategies to repair it remain unclear. Here, we demonstrate for the first time the direct consequences and potential mechanisms of mitochondrial functional defects associated with abnormal mitochondrial dynamics in AD. Using cytoplasmic hybrid (cybrid) neurons with incorporated platelet mitochondria from AD and age-matched non-AD human subjects into mitochondrial DNA (mtDNA)-depleted neuronal cells, we observed that AD cybrid cells had significant changes in morphology and function; such changes associate with altered expression and distribution of dynamin-like protein (DLP1) and mitofusin 2 (Mfn2). Treatment with antioxidant protects against AD mitochondria-induced extracellular signal-regulated kinase (ERK) activation and mitochondrial fission-fusion imbalances. Notably, inhibition of ERK activation not only attenuates aberrant mitochondrial morphology and function but also restores the mitochondrial fission and fusion balance. These effects suggest a role of oxidative stress-mediated ERK signal transduction in modulation of mitochondrial fission and fusion events. Further, blockade of the mitochondrial fission protein DLP1 by a genetic manipulation with a dominant negative DLP1 (DLP1K38A), its expression with siRNA-DLP1, or inhibition of mitochondrial division with mdivi-1 attenuates mitochondrial functional defects observed in AD cybrid cells. Our results provide new insights into mitochondrial dysfunction resulting from changes in the ERK-fission/fusion (DLP1) machinery and signaling pathway. The protective effect of mdivi-1 and inhibition of ERK signaling on maintenance of normal mitochondrial structure and function holds promise as a potential novel therapeutic strategy for AD

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

Mitochondrial dysfunction is an early pathological feature of Alzheimer’s disease (AD). The underlying mechanisms and strategies to repair it remain unclear. Here, we demonstrate for the first time the direct consequences and potential mechanisms of mitochondrial functional defects associated with abnormal mitochondrial dynamics in AD. Using cytoplasmic hybrid (cybrid) neurons with incorporated platelet mitochondria from AD and age-matched non-AD human subjects into mitochondrial DNA (mtDNA)-depleted neuronal cells, we observed that AD cybrid cells had significant changes in morphology and function; such changes associate with altered expression and distribution of dynamin-like protein (DLP1) and mitofusin 2 (Mfn2). Treatment with antioxidant protects against AD mitochondria-induced extracellular signal-regulated kinase (ERK) activation and mitochondrial fission-fusion imbalances. Notably, inhibition of ERK activation not only attenuates aberrant mitochondrial morphology and function but also restores the mitochondrial fission and fusion balance. These effects suggest a role of oxidative stress-mediated ERK signal transduction in modulation of mitochondrial fission and fusion events. Further, blockade of the mitochondrial fission protein DLP1 by a genetic manipulation with a dominant negative DLP1 (DLP1K38A), its expression with siRNA-DLP1, or inhibition of mitochondrial division with mdivi-1 attenuates mitochondrial functional defects observed in AD cybrid cells. Our results provide new insights into mitochondrial dysfunction resulting from changes in the ERK-fission/fusion (DLP1) machinery and signaling pathway. The protective effect of mdivi-1 and inhibition of ERK signaling on maintenance of normal mitochondrial structure and function holds promise as a potential novel therapeutic strategy for AD

Community trauma exposure and post-traumatic stress disorder in Chinese children and adolescents

BackgroundAn increasing number of studies have shown the association between traumatic events occurring in childhood and adolescence and post-traumatic stress disorder (PTSD). A gap remains in the literature on the epidemiology and influencing factors of traumatic events and post-traumatic stress disorder in communities in northern China. This study aimed to determine the prevalence of traumatic events and PTSD in communities in northern China, to explore the types of stressful traumatic events and the impact of these traumatic events on children and adolescents, and to investigate the effect of sociodemographic factors on PTSD.MethodsA cross-sectional survey study was conducted among 6,027 students (7–17 years old) from 6 cities in Liaoning Province, China. The sample consisted of 2,853 males (47.34%) and 3,174 females (52.66%). The Essen Trauma-Inventory for Children and Adolescents (ETI-CA) Scale was used. The ETI-CA has 5 sections, which include type of traumatic events, worst traumatic event, post-traumatic symptoms, onset, duration, burden of PTSD, and present difficulties in different areas of life. PTSD symptoms were assessed with 23 items in Part 3 of the ETI-CA.ResultsWe found that 2,068 (34.3%) of 6,027 participants experienced trauma events and 686 (33.2%) of 2,068 reported PTSD. Among trauma-exposed youth (2,068), the sudden death of close relatives (33.9%), serious accidents (20.9%), and parental divorce (15.5%) were reported as the worst traumatic events. Studies have shown that after exposure to stressful life events, more than 30% of people feel nervous or upset (39.8%), scared (33.4%), helpless (32.6%), and about 10% have headaches (15.5%), rapid heartbeat (13.3%), and dizziness (11.8%). Multivariable logistic regression analyses showed that students in middle school [OR = 1.29 (1.016, 1.637)], not a student leader [OR = 0.738 (0.618, 0.881)], and their parents in single marital status significantly predicted higher PTSD prevalence the remarried [OR = 0.474 (0.252, 0.893)], married [OR = 0.42 (0.227, 0.778)].ConclusionThe present study suggests the government to train psychological counselors in schools and communities to provide emotional and psychological support, as well as the school leaders and parents to elevate adolescents' psychological suzhi. Particularly, counseling and professional support should be given to those students whose parents are single

Effect of Tin Addition on the Degradability and Corrosion Properties of a New Zn-1.0 wt.% Mg Alloy

In this study, to investigate effects of tin addition on the microstructures and corrosion properties, Zn-1Mg-xSn (x = 1.0, 2.0 and 5.0 wt.%) ternary zinc alloys were prepared. The experimental results indicated that the Zn-1Mg-2.0 wt.% Sn alloy has the better mechanical properties compared with pure zinc and Zn-1Mg alloy. The tensile strength of the alloy material is 173.2±3.7 MPa, the yield strength is 120.7±2.4 MPa, the elongation is 5.64±0.08% and the hardness is 76.9±0.8 HV. The average degradation rate of the alloys immersion in SBF solution for 60 days is 0.16±0.03 mm/year, and the Zn-1Mg-2.0 wt.% Sn alloy hemolysis rate is only 0.81±0.02%. It is confirmed that the addition of tin is effective to improve the mechanical properties and degradation of Zn-1Mg alloy. It may be a candidate of the clinical application requirements of the degradable implant materials in orthopedics

A Two-Stage Calibration Method for Low-Cost UAV Attitude Estimation Using Infrared Sensor

Infrared (IR) sensors are widely used on robotics platforms for measurement purposes. Low-cost small unmanned aerial vehicles (UAVs) have drawn broad interests during recent years for their various uses in many applications. This paper introduces a two-stage IR sensor calibration method for the attitude estimation of low-cost UAVs. The first stage is based on ground and flight tuning procedures, which are concluded from experience; the second stage is to use the calibration algorithm with inertial measurement unit (IMU) as the baseline reference. The implementation and optimization of the proposed algorithm is described and explained in detail. The experimental flight results are compared and discussed in the end