Determination of carbonyl compounds in exhaled breath by on-sorbent derivatization coupled with thermal desorption and gas chromatography-tandem mass spectrometry

A reliable method for the determination of carbonyl compounds in exhaled breath based on on-sorbent derivatization coupled with thermal desorption and gas chromatography-tandem mass spectrometry is described. The analytical performances were optimized for a mixture of C2-C9 aldehydes and C3-C9 ketones, particularly interesting for clinical applications, by using an internal standard and applying a 2^3 full factorial design. A volume of sample (250 ml) was loaded at 50 ml min-1 into a Tenax GR sorbent tube containing 130 nmol of O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride. All compounds showed a limit of detection lower than 200 pptv. The yield of the derivatization procedure was normalized by adding to the sample a known amount of 6D-acetone as an internal standard. This allowed halving the relative standard deviation to 10% and 15% for the mono-and di-carbonyl compounds, respectively, thus improving reliability. The optimized method was applied to the determination of carbonyl compounds in 12 breath samples collected from four patients suffering from heart failure during hospitalization

New infrastructure for studies of transmutation and fast systems concepts

In this work we report initial studies on a low power Accelerator-Driven System as a possible experimental facility for the measurement of relevant integral nuclear quantities. In particular, we performed Monte Carlo simulations of minor actinides and fission products irradiation and estimated the fission rate within fission chambers in the reactor core and the reflector, in order to evaluate the transmutation rates and the measurement sensitivity. We also performed a photo-peak analysis of available experimental data from a research reactor, in order to estimate the expected sensitivity of this analysis method on the irradiation of samples in the ADS considered

Bio-based benzoxazines synthesized in a deep eutectic solvent: A greener approach toward vesicular nanosystems

A green synthesis of benzoxazines, based upon reaction of cardanol with formaldehyde and primary amines, is achieved in high yields using choline chloride-urea mixture as deep eutectic solvent. Then, it is demonstrated how the cardanol-based benxoxazines can be employed as only component for the preparation of a nanovesicular systems

An algebraic classification of entangled states

We provide a classification of entangled states that uses new discrete entanglement invariants. The invariants are defined by algebraic properties of linear maps associated with the states. We prove a theorem on a correspondence between the invariants and sets of equivalent classes of entangled states. The new method works for an arbitrary finite number of finite-dimensional state subspaces. As an application of the method, we considered a large selection of cases of three subspaces of various dimensions. We also obtain an entanglement classification of four qubits, where we find 27 fundamental sets of classes.Comment: published versio

On manifolds with nonhomogeneous factors

We present simple examples of finite-dimensional connected homogeneous spaces (they are actually topological manifolds) with nonhomogeneous and nonrigid factors. In particular, we give an elementary solution of an old problem in general topology concerning homogeneous spaces

Comparison of sampling bags for the analysis of volatile organic compounds in breath

Nalophan, Tedlar and Cali-5-Bond polymeric bags were compared to determine the most suitable type for breath sampling and storage when volatile organic compounds are to be determined. Analyses were performed by thermal desorption gas chromatography mass spectrometry. For each bag, the release of contaminants and the chemical stability of a gaseous standard mixture containing eighteen organic compounds, as well as the CO2 partial pressure were assessed. The selected compounds were representative of breath constituents and belonged to different chemical classes (i.e. hydrocarbons, ketones, aldehydes, aromatics, sulfurs and esters). In the case of Nalophan, the influence of the surface-to-volume ratio, related to the bag's filling degree, on the chemical stability was also evaluated. Nalophan bags were found to be the most suitable in terms of contaminants released during storage (only 2-methyl-1,3-dioxalane), good sample stability (up to 24 h for both dry and humid samples), and very limited costs (about 1 for a 20 liter bag). The (film) surface-to-(sample) volume ratio was found to be an important factor affecting the stability of selected compounds, and therefore we recommended to fill the bag completely

Teleportation, Braid Group and Temperley--Lieb Algebra

We explore algebraic and topological structures underlying the quantum teleportation phenomena by applying the braid group and Temperley--Lieb algebra. We realize the braid teleportation configuration, teleportation swapping and virtual braid representation in the standard description of the teleportation. We devise diagrammatic rules for quantum circuits involving maximally entangled states and apply them to three sorts of descriptions of the teleportation: the transfer operator, quantum measurements and characteristic equations, and further propose the Temperley--Lieb algebra under local unitary transformations to be a mathematical structure underlying the teleportation. We compare our diagrammatical approach with two known recipes to the quantum information flow: the teleportation topology and strongly compact closed category, in order to explain our diagrammatic rules to be a natural diagrammatic language for the teleportation.Comment: 33 pages, 19 figures, latex. The present article is a short version of the preprint, quant-ph/0601050, which includes details of calculation, more topics such as topological diagrammatical operations and entanglement swapping, and calls the Temperley--Lieb category for the collection of all the Temperley--Lieb algebra with physical operations like local unitary transformation

MS-based targeted profiling of oxylipins in COVID-19: A new insight into inflammation regulation

The key role of inflammation in COVID-19 induced many authors to study the cytokine storm, whereas the role of other inflammatory mediators such as oxylipins is still poorly understood. IMPRECOVID was a monocentric retrospective observational pilot study with COVID-19 related pneumonia patients (n = 52) admitted to Pisa University Hospital between March and April 2020. Our MS-based analytical platform permitted the simultaneous determination of sixty plasma oxylipins in a single run at ppt levels for a comprehensive characterisation of the inflammatory cascade in COVID-19 patients. The datasets containing oxylipin and cytokine plasma levels were analysed by principal component analysis (PCA), computation of Fisher's canonical variable, and a multivariate receiver operating characteristic (ROC) curve. Differently from cytokines, the panel of oxylipins clearly differentiated samples collected in COVID-19 wards (n = 43) and Intensive Care Units (ICUs) (n = 27), as shown by the PCA and the multivariate ROC curve with a resulting AUC equal to 0.92. ICU patients showed lower (down to two orders of magnitude) plasma concentrations of anti-inflammatory and pro-resolving lipid mediators, suggesting an impaired inflammation response as part of a prolonged and unsolvable pro-inflammatory status. In conclusion, our targeted oxylipidomics platform helped shedding new light in this field. Targeting the lipid mediator class switching is extremely important for a timely picture of a patient's ability to respond to the viral attack. A prediction model exploiting selected lipid mediators as biomarkers seems to have good chances to classify patients at risk of severe COVID-19

Quantum geometry and quantum algorithms

Motivated by algorithmic problems arising in quantum field theories whose dynamical variables are geometric in nature, we provide a quantum algorithm that efficiently approximates the colored Jones polynomial. The construction is based on the complete solution of Chern-Simons topological quantum field theory and its connection to Wess-Zumino-Witten conformal field theory. The colored Jones polynomial is expressed as the expectation value of the evolution of the q-deformed spin-network quantum automaton. A quantum circuit is constructed capable of simulating the automaton and hence of computing such expectation value. The latter is efficiently approximated using a standard sampling procedure in quantum computation.Comment: Submitted to J. Phys. A: Math-Gen, for the special issue ``The Quantum Universe'' in honor of G. C. Ghirard