Why surface nanobubbles live for hours

We present a theoretical model for the experimentally found but counter-intuitive exceptionally long lifetime of surface nanobubbles. We can explain why, under normal experimental conditions, surface nanobubbles are stable for many hours or even up to days rather than the expected microseconds. The limited gas diffusion through the water in the far field, the cooperative effect of nanobubble clusters, and the pinned contact line of the nanobubbles lead to the slow dissolution rate.Comment: 5 pages, 3 figure

Inert gas accumulation in sonoluminescing bubbles

In this paper we elaborate on the idea [Lohse et al., Phys. Rev. Lett. 78, 1359-1362 (1997)] that (single) sonoluminescing air bubbles rectify argon. The reason for the rectification is that nitrogen and oxygen dissociate and their reaction products dissolve in water. We give further experimental and theoretical evidence and extend the theory to other gas mixtures. We show that in the absence of chemical reactions (e.g., for inert gas mixtures) gas accumulation in strongly acoustically driven bubbles can also occur.Comment: J. Chem. Phys., in press (to appear in November 1997), 30 pages, 15 eps-figure

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients

The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease. CARD15 functions as an intracellular receptor for bacterial components and thus represents an important link between inflammatory bowel disease and innate immunity. Three major CARD15/NOD2 gene mutations have been associated with Crohn's disease in Caucasians in several independent studies. Together, they explain about 20% of the genetic susceptibility for Crohn's disease. Genotype-phenotype analyses demonstrated an association of these mutations with ileum-specific disease, an increased incidence of the fibrostenotic phenotype and an earlier age of disease onset. Beside these associations, no other relationship between the CARD15/NOD2 genotype and disease behavior or response to treatment has been detailed so far. Thus, the clinical impact of knowing the patient's genotype is limited at this time. Screening for CARD15 mutations in order to identify high-risk individuals or to introduce an individualized disease management is therefore currently not recommended. Copyright (C) 2003 S. Karger AG, Basel

R116C mutation of cationic trypsinogen in a Turkish family with recurrent pancreatitis illustrates genetic microheterogeneity of hereditary pancreatitis

Hereditary pancreatitis is due to heterozygosity for gain-of-function mutations in the cationic trypsinogen gene which result in increased levels of active trypsin within pancreatic acinar cells and autodigestion of the pancreas. The number of disease-causing defects is generally considered to be low. To gain further insight into the molecular basis of this disorder, DNA sequence analysis of all five exons was performed in 109 unrelated patients with idiopathic chronic pancreatitis in order to determine the variability of the underlying mutations. Two German females and one German male were carriers of the most common N291 and R122H mutations (trypsinogen numbering system). In a Turkish proband, an arginine (CGT) to cysteine (TGT) substitution at amino acid position 116 was identified. Family screening demonstrated that the patient had inherited the mutation from his asymptomatic father and that he had transmitted it to both of his children, his daughter being symptomatic since the age of 3 years. In addition, a German male was found to be a heterozygote for a D100H (GAC-->CAC) amino acid replacement. Our data provide evidence for genetic heterogeneity of hereditary pancreatitis. The growing number of cationic trypsinogen mutations is expected to change current mutation screening practices for this disease

Optimal Prandtl number for heat transfer in rotating Rayleigh-Benard convection

Numerical data for the heat transfer as a function of the Prandtl (Pr) and Rossby (Ro) numbers in turbulent rotating Rayleigh-Benard convection are presented for Rayleigh number Ra = 10^8. When Ro is fixed the heat transfer enhancement with respect to the non-rotating value shows a maximum as function of Pr. This maximum is due to the reduced efficiency of Ekman pumping when Pr becomes too small or too large. When Pr becomes small, i.e. for large thermal diffusivity, the heat that is carried by the vertical vortices spreads out in the middle of the cell, and Ekman pumping thus becomes less efficient. For higher Pr the thermal boundary layers (BLs) are thinner than the kinetic BLs and therefore the Ekman vortices do not reach the thermal BL. This means that the fluid that is sucked into the vertical vortices is colder than for lower Pr which limits the efficiency of the upwards heat transfer.Comment: 5 pages, 6 figure

Order-to-disorder transition in ring-shaped colloidal stains

A colloidal dispersion droplet evaporating from a surface, such as a drying coffee drop, leaves a distinct ring-shaped stain. Although this mechanism is frequently used for particle self-assembly, the conditions for crystallization have remained unclear. Our experiments with monodisperse colloidal particles reveal a structural transition in the stain, from ordered crystals to disordered packings. We show that this sharp transition originates from a temporal singularity of the flow velocity inside the evaporating droplet at the end of its life. When the deposition speed is low, particles have time to arrange by Brownian motion, while at the end, high-speed particles are jammed into a disordered phase.Comment: accepted for PR

Quantifying microbubble clustering in turbulent flow from single-point measurements

Single-point hot-wire measurements in the bulk of a turbulent channel have been performed in order to detect and quantify the phenomenon of preferential bubble accumulation. We show that statistical analysis of the bubble-probe colliding-times series can give a robust method for investigation of clustering in the bulk regions of a turbulent flow where, due to the opacity of the flow, no imaging technique can be employed. We demonstrate that micro-bubbles (radius R_0 ~ 0.1 mm) in a developed turbulent flow, where the Kolmogorov length-scale is, eta ~ R_0, display preferential concentration in small scale structures with a typical statistical signature ranging from the dissipative range, O(eta), up to the low inertial range, O(100 eta). A comparison with Eulerian-Lagrangian numeri- cal simulations is also presented to further support our proposed way to characterize clustering from temporal time series at a fixed position.Comment: 7 pages, 4 figure