A comparative study of inflammatory marker highly sensitive C- Reactive Protein in depression patients exhibiting suicidal behaviour and depression patients without suicidal behaviour

Background: Recent research have found a link between inflammatory pathway and suicidal behaviour. hs-CRP, IL, TNF have been shown to have significant alterations in suicidality, however multiple covariates influence this relationship. One of the main limitations of most of the studies is that they have evaluated the CRP in patients demonstrating suicidal behaviour but not in depression. No study has been conducted in Indian subpopulation with parameters of our study. Aims of the study was to compare hsCRP levels between depression patients with suicidal behaviour and without suicidal behaviour.Methods: Authors compared 50 depression patients with suicidal behaviour and 50 depression patients without suicidal behaviour, diagnosed using ICD10. Hamilton Depression Rating Scale (HDRS‑17), Suicide behaviour Questionnaire- Revised (SBQ-R), Beck Scale for Suicidal Ideation (BSSI) were applied for assessment of depression and suicidality. Highly sensitive CRP was measured using autoanalyzer.Results: hsCRP levels were significantly high in depression patients with suicidal behaviour (4.12 mg/dl) than depression without suicidal behaviour (2.42 mg/dl). Duration of illness, HAM-D, BSSI and SBQ-R scores correlated positively with hsCRP levels.Conclusions: Depression with suicidal behaviour patients have a significantly higher hs-CRP levels than depression without suicidal behaviour. Patients of depression with suicidal behaviour group have a strong positive correlation between hs-CRP levels and HAM-D, BSSI and SBQ-R scores

Clinico-biochemical correlation between psoriasis and lipid profile

Background: Psoriasis is an autoimmune disorder associated with alteration of different metabolism. The present study was aimed to assess the lipid metabolism and its correlation with severity of disease and associated cardiovascular risk factors in psoriasis.Methods: Study comprises total of 60 cases of psoriasis attended the dermatology clinics at Maharaja Yashwant Rao hospital, Indore, Madhya Pradesh, India and 30 age, gender matched healthy controls. Subjects were enrolled in the study as per the inclusion criteria. Severity of the disease was assessed by PASI score. Fasting blood samples were collected and evaluated for Lipid profile and risk ratio was calculated.Results: The results indicated that serum total cholesterol, triglycerides, LDL-C,VLDL-C were significantly increased in moderate to severe cases in comparison to control and level of HDL-C significantly decreased in moderate psoriasis and highly significant decreased was observed in severe cases when compared to control. Serum triglyceride (TG), total cholesterol, low density lipoprotein showed a significant positive correlation with severity of psoriasis. Study concludes that lipid derangement correlate with the severity of disease and also acts as a good prognostic sign.  Conclusions: Present study concludes that psoriatic patients should be evaluated and followed up for the risk of dyslipidemia and cardiovascular morbidity

Study on clinical profile of acute pancreatitis from a tertiary care teaching institute of western Uttar Pradesh: Clinical profile of acute pancreatitis

Objective- To study the clinical profile of subjects diagnosed and managed for acute pancreatitis at a tertiary care teaching institute of western Uttar Pradesh. Methods- All the cases diagnosed and managed for acute pancreatitis at the study place and during the study time formed the study population. All the cases were followed up till the outcome of the case. A detailed proforma was designed to capture relevant details of study subjects. Results- Underlying cause of the clinical condition was noted as alcoholic in nature by majority (80%) of the study subjects. In 10 patients (16.7%) reason for the pancreatitis could not be ascertained despite extensive evaluation. Common complications of the clinical condition were noted as pleural effusion (n=12, 20%) followed by ascitis (n=9, 15%) and acute fluid collection (n=5, 8.3%). Morality was seen among 2 patients (3.3%). Conclusion- In this region of the western Uttar Pradesh, alcohol is the most frequent cause of acute pancreatitis. Males are more likely to get the condition, and it typically manifests in the fourth decade of life. Biochemical and radiological results supplement the primary clinical diagnosis

Clinico-biochemical correlation between psoriasis and lipid profile

Background: Psoriasis is an autoimmune disorder associated with alteration of different metabolism. The present study was aimed to assess the lipid metabolism and its correlation with severity of disease and associated cardiovascular risk factors in psoriasis.Methods: Study comprises total of 60 cases of psoriasis attended the dermatology clinics at Maharaja Yashwant Rao hospital, Indore, Madhya Pradesh, India and 30 age, gender matched healthy controls. Subjects were enrolled in the study as per the inclusion criteria. Severity of the disease was assessed by PASI score. Fasting blood samples were collected and evaluated for Lipid profile and risk ratio was calculated.Results: The results indicated that serum total cholesterol, triglycerides, LDL-C,VLDL-C were significantly increased in moderate to severe cases in comparison to control and level of HDL-C significantly decreased in moderate psoriasis and highly significant decreased was observed in severe cases when compared to control. Serum triglyceride (TG), total cholesterol, low density lipoprotein showed a significant positive correlation with severity of psoriasis. Study concludes that lipid derangement correlate with the severity of disease and also acts as a good prognostic sign.  Conclusions: Present study concludes that psoriatic patients should be evaluated and followed up for the risk of dyslipidemia and cardiovascular morbidity

Study of serum leptin levels in patients with type 2 diabetes mellitus at a tertiary care centre of central India

Background: It has been reported that Insulin and leptin share a common central signaling pathway and there might be a possible role of leptin in the etiology of type 2 DM. Studies regarding role of leptin in type 2 DM in central India are lacking. Aim: This study was conducted with the aim of comparing leptin levels in patients with type 2 DM with apparently healthy controls. Subjects and Methods: A total of 80 subjects including 40 patients of type 2 DM attending outdoor clinics of MY Hospital and 40 age and sex matched healthy controls. Fasting venous blood sample was analysed for leptin, total cholesterol (TC), triglycerides (TG), HDL-C and fasting blood sugar (FBS). Statistical analysis was performed using SPSS software version 14. Results: Mean BMI of diabetic group was 32 ± 3.48kg/m2 and that of control group was 28 ± 2.56kg/m2. Leptin levels among diabetic cases were 29.3± 19.3 ng/ml and in non diabetic subjects it was 34.8 ±21.4 ng/ml. The difference in leptin levels between cases and control were statistically significant. Conclusion: Low leptin levels are associated with type 2 diabetes mellitus independent of changes in BMI