Bounds on the Size of the Likelihood Ratio Test of Independence in a Contingency Table

AbstractBounds are obtained on the limiting size of the nominal level-α likelihood ratio test of independence in a r × c contingency table. The situations considered include sampling with both marginal totals random and with one margin fixed. Upper and lower bounds are obtained. The limiting size is greater than α when some marginal probabilities are small. As the degrees of freedom increase, the limiting size tends to 1 for all α-values

Dynamic protein methylation in chromatin biology

Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals

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