61 research outputs found
<a name="home"></a>The role of IFN-gamma and IL-4 in gastric mucosa inflammation associated with Helicobacter heilmannii type 1 infection
13C-Urea breath test: Reproducibility and association with the severity of Helicobacter pylori-associated antral gastritis
BackgroundThe purpose of the present paper was to assess the reproducibility of the (13)C-urea breath test ((13)C-UBT) and its ability to reflect the level of Helicobacter pylori-associated inflammation.MethodsAsymptomatic H. pylori-positive subjects (n = 21) performed the (13)C-UBT six times. The H. pylori-positive symptomatic subjects (n = 55) performed the (13)C-UBT and had antral biopsies taken for histopathology, culture, urease activity assay and myeloperoxidase activity assay.ResultsNo significant intraindividual variation in (13)C-UBT results were observed for the asymptomatic subjects. The (13)C-UBT results were significantly higher in symptomatic subjects with a moderate to severe gastritis compared to a mild gastritis and to no inflammation (34.5 +/- 4.4 vs 17.7 +/- 2.8 vs 1.7 +/- 0.1, respectively, P < 0.01). The (13)C-UBT results significantly correlated with urease (r = 0.55) and myeloperoxidase activity (r = 0.82) but not with bacterial load. conclusion: The (13)C-UBT is a reproducible determinant of H. pylori infection and non-invasively assesses the severity of antral inflammation.Matthews, Geoffrey M; Cummins, Adrian G; Lawrence, Andrew; Johnson, Bruce; Campbell, Fiona; Butler, Ross
Applicability of Polymerase Chain Reaction Assay for Detecting Helicobacter pylori in Gastric Juice Aspirates
Double-blind, Multicenter, Placebo-Controlled Evaluation Of Clarithromycin And Omeprazole For Helicobacter Pylori-Associated Duodenal Ulcer
An evaluative system for the response of antibacterial therapy: Based on the morphological change of Helicobacter pylori
Helicobacter pylori?Positive Duodenal Ulcer: A Long-Term Double-Blind Randomized Study in Patients Healed with H 2
Helicobacter Pylori Eradication for Peptic Ulceration: An Observational Study in a Scottish Primary Care Setting
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