Fitness-dependent topological properties of the World Trade Web

Among the proposed network models, the hidden variable (or good get richer) one is particularly interesting, even if an explicit empirical test of its hypotheses has not yet been performed on a real network. Here we provide the first empirical test of this mechanism on the world trade web, the network defined by the trade relationships between world countries. We find that the power-law distributed gross domestic product can be successfully identified with the hidden variable (or fitness) determining the topology of the world trade web: all previously studied properties up to third-order correlation structure (degree distribution, degree correlations and hierarchy) are found to be in excellent agreement with the predictions of the model. The choice of the connection probability is such that all realizations of the network with the same degree sequence are equiprobable.Comment: 4 Pages, 4 Figures. Final version accepted for publication on Physical Review Letter

Patterns of link reciprocity in directed networks

We address the problem of link reciprocity, the non-random presence of two mutual links between pairs of vertices. We propose a new measure of reciprocity that allows the ordering of networks according to their actual degree of correlation between mutual links. We find that real networks are always either correlated or anticorrelated, and that networks of the same type (economic, social, cellular, financial, ecological, etc.) display similar values of the reciprocity. The observed patterns are not reproduced by current models. This leads us to introduce a more general framework where mutual links occur with a conditional connection probability. In some of the studied networks we discuss the form of the conditional connection probability and the size dependence of the reciprocity.Comment: Final version accepted for publication on Physical Review Letter

Laue Lens Development for Hard X-rays (>60 keV)

Results of reflectivity measurements of mosaic crystal samples of Cu (111) are reported. These tests were performed in the context of a feasibility study of a hard X-ray focusing telescope for space astronomy with energy passband from 60 to 600 keV. The technique envisaged is that of using mosaic crystals in transmission configuration that diffract X-rays for Bragg diffraction (Laue lens). The Laue lens assumed has a spherical shape with focal length $f$. It is made of flat mosaic crystal tiles suitably positioned in the lens. The samples were grown and worked for this project at the Institute Laue-Langevin (ILL) in Grenoble (France), while the reflectivity tests were performed at the X-ray facility of the Physics Department of the University of Ferrara.Comment: 6 pages, 12 figures, accepted for publication in IEEE Transactions on Nuclear Scienc

Evaluating the Impact of PSA as a Selection Criteria for Nerve Sparing Radical Prostatectomy in a Screened Cohort

Purpose. We investigated whether NS-RP increased risk of PSA failure and whether PSA should be included as a selection criterion for NS. Methods:. We evaluated 357 consecutive men with screen-detected PC who underwent open RP without adjuvant radiotherapy between 9/11/2001 and 12/30/2008. Criteria for NS included Gleason score ≤3 + 4, percentage of positive biopsies (PPB) ≤50%, percentage of core involvement ≤50%, nonapical location, no perineural invasion, and no palpable disease on pre- or intraoperative exam but did not include a PSA threshold. Cox multivariable regression assessed whether increasing PSA or unilateral- or bilateral-NS versus non-NS-RP was associated with PSA failure adjusting for prognostic factors. Results:. After a median follow-up of 3.96 years, 34 men sustained PSA failure (9.5%). Increasing PSA was significantly associated with increased risk of PSA failure in the interaction model (adjusted hazard ratio (AHR): 1.09 [95% CI: 1.03–1.16]; P = 0.005), whereas unilateral (AHR: 1.24 [95% CI: 0.36–4.34]; P = 0.73) or bilateral NS (AHR: 0.41 [95% CI: 0.06–2.59]; P = 0.34) versus non-NS RP was not. Conclusion:. NS-RP in a screened cohort did not increase risk of PSA failure using NS criteria not including PSA

New results on focusing of gamma-rays with Laue lenses

We report on new results on the development activity of broad band Laue lenses for hard X-/gamma-ray astronomy (70/100-600 keV). After the development of a first prototype, whose performance was presented at the SPIE conference on Astronomical Telescopes held last year in Marseille (Frontera et al. 2008), we have improved the lens assembling technology. We present the development status of the new lens prototype that is on the way to be assembled.Comment: 8 pages, 11 figures, to be Published in SPIE Proceedings, vol.7437-19, 200

Development status of a Laue lens project for gamma-ray astronomy

We report the status of the HAXTEL project, devoted to perform a design study and the development of a Laue lens prototype. After a summary of the major results of the design study, the approach adopted to develop a Demonstration Model of a Laue lens is discussed, the set up described, and some results presented.Comment: 11 pages, 11 figures, 2007 SPIE Conference on Optics for EUV, X-Ray, and Gamma-Ray Astronomy II

Exploring the Hard X-/soft gamma-ray Continuum Spectra with Laue Lenses

The history of X-ray astronomy has shown that any advancement in our knowledge of the X-ray sky is strictly related to an increase in instrument sensitivity. At energies above 60 keV, there are interesting prospects for greatly improving the limiting sensitivity of the current generation of direct viewing telescopes (with or without coded masks), offered by the use of Laue lenses. We will discuss below the development status of a Hard X-Ray focusing Telescope (HAXTEL) based on Laue lenses with a broad bandpass (from 60 to 600 keV) for the study of the X-ray continuum of celestial sources. We show two examplesof multi-lens configurations with expected sensitivity orders of magnitude better ($\sim 1 \times 10^{-8}$ photons cm$^{-2}$ s$^{-1}$ keV$^{-1}$ at 200 keV) than that achieved so far. With this unprecedented sensitivity, very exciting astrophysical prospects are opened.Comment: 4 pages, 10 figures, to be published in the Proc. of the 39th ESLAB Symosium, 19-21 April 200

KDEON WK-11: A short antipseudomonal peptide with promising potential

The plight of antimicrobial resistance continues to limit the availability of antibiotic treatment effective in combating resistant bacterial infections. Despite efforts made to rectify this issue and minimise its effects on both patients and the wider community, progress in this area remains minimal. Here, we de-novo designed a peptide named KDEON WK-11, building on previous work establishing effective residues and structures active in distinguished antimicrobial peptides such as lactoferrin. We assessed its antimicrobial activity against an array of bacterial strains and identified its most potent effect, against Pseudomonas aeruginosa with an MIC value of 3.12 mu M, lower than its counterparts developed with similar residues and chain lengths. We then determined its anti-biofilm properties, potential mechanism of action and in vitro cytotoxicity. We identified that KDEON WK-11 had a broad range of antimicrobial activity and specific capabilities to fight Pseudomonas aeruginosa with low in vitro cytotoxicity and promising potential to express anti-lipopolysaccharide qualities, which could be exploited to expand its properties into an anti-sepsis agent

Feasibility study of a Laue lens for hard X-rays for space astronomy

We report on the feasibility study of a Laue lens for hard X-rays (>60 keV)based on mosaic crystals, for astrophysical applications. In particular we discuss the scientific motivations, its functioning principle, the procedure followed to select the suitable crystal materials, the criteria adopted to establish crystal dimensions and their distribution on the lens in order to obtain the best lens focusing capabilities, and the criteria for optimizing the lens effective area in a given passband. We also discuss the effects of misalignments of the crystal tiles due to unavoidable mechanical errors in assembling the lens. A software was developed to face all these topics and to evaluate the expected lens performance.Comment: 10 pages, corrected Fig. 1b and Fig. 2, which are wrong in the published version, corrected typo