68 research outputs found
Optimal Structure and Dissolution of Partnerships
We derive the optimal incentive compatible and individually rational mechanisms to reallocate arbitrary given ownership shares among a set of agents. These mechanisms are optimal in the sense that they maximize social surplus of the final allocation subject to the aforementioned constraints and a revenue constraint. We allow for the agents' types to be drawn from non-identical distributions and for interdependent values. Because outside options are type dependent, the critical types for which individual rationality binds must be determined simultaneously with the allocation rule. We show that optimality uniquely pins down the set of critical types, which allows us to fully characterize the optimal mechanisms. Moreover, we find that the value function is Schur-concave in ownership shares when types are identically distributed, so that more symmetric shares are better irrespective of size of the revenue constraint
Vertical Intra-Industry Trade, Technology and Income Distribution: A Panel Data Analysis of EU Trade with Central-East European Countries
This article tests a Heckscher-Ohlin framework versus a neo-Ricardian framework for explaining vertical intra-industry trade. The study applies panel techniques with instrument variables to analyse trade between 'old' EU and 10 Central-East European countries in their transition period. Results show country-pair fixed effects to be of high relevance for explaining vertical intra-industry trade. Technology differences are positively, while differences in factor endowment measured in GDP per capita, are negatively correlated with vertical intra-industry trade, and confirm the relevance of the neo-Ricardian framework. In addition, changing bilateral differences in personal income distribution during the transition of Central-East European countries towards a market economy contribute to changes in vertical intra-industry trade
SN 2022oqm: A Multi-peaked Calcium-rich Transient from a White Dwarf Binary Progenitor System
We present the photometric and spectroscopic evolution of SN 2022oqm, a
nearby multi-peaked hydrogen- and helium-weak calcium-rich transient (CaRT). SN
2022oqm was detected 19.9 kpc from its host galaxy, the face-on spiral galaxy
NGC 5875. Extensive spectroscopic coverage reveals a hot (T >= 40,000 K)
continuum and carbon features observed ~1 day after discovery, SN Ic-like
photospheric-phase spectra, and strong forbidden calcium emission starting 38
days after discovery. SN 2022oqm has a relatively high peak luminosity (MB =
-17 mag) for CaRTs, making it an outlier in the population. We determine that
three power sources are necessary to explain SN 2022oqm's light curve, with
each power source corresponding to a distinct peak in its light curve. The
first peak of the light curve is powered by an expanding blackbody with a power
law luminosity, consistent with shock cooling by circumstellar material.
Subsequent peaks are powered by a double radioactive decay model, consistent
with two separate sources of photons diffusing through an optically thick
ejecta. From the optical light curve, we derive an ejecta mass and 56Ni mass of
~0.89 solar masses and ~0.09 solar masses, respectively. Detailed spectroscopic
modeling reveals ejecta that is dominated by intermediate-mass elements, with
signs that Fe-peak elements have been well-mixed. We discuss several physical
origins for SN 2022oqm and favor a white dwarf progenitor model. The inferred
ejecta mass points to a surprisingly massive white dwarf, challenging models of
CaRT progenitors.Comment: 33 pages, 17 figures, 5 tables, Submitted to Ap
Darbepoetin Administration to Neonates Undergoing Cooling for Encephalopathy: A Safety and Pharmacokinetic Trial
Background:
Despite therapeutic hypothermia, neonates with encephalopathy (NE) have high rates of death or disability. Darbepoetin alfa (Darbe) has comparable biological activity to erythropoietin, but has extended circulating half-life (t1/2). Our aim was to determine Darbe safety and pharmacokinetics as adjunctive therapy to hypothermia. Study design:
Thirty infants (n = 10/arm) ≥36 wk gestation undergoing therapeutic hypothermia for NE were randomized to receive placebo, Darbe low dose (2 μg/kg), or high dose (10 μg/kg) given intravenously within 12 h of birth (first dose/hypothermia condition) and at 7 d (second dose/normothermia condition). Adverse events were documented for 1 mo. Serum samples were obtained to characterize Darbe pharmacokinetics. Results:
Adverse events (hypotension, altered liver and renal function, seizures, and death) were similar to placebo and historical controls. Following the first Darbe dose at 2 and 10 μg/kg, t1/2 was 24 and 32 h, and the area under the curve (AUCinf) was 26,555 and 180,886 h*mU/ml*, respectively. In addition, clearance was not significantly different between the doses (0.05 and 0.04 l/h). At 7 d, t1/2 was 26 and 35 h, and AUCinf was 10,790 and 56,233 h*mU/ml*, respectively (*P \u3c 0.01). Conclusion:
Darbe combined with hypothermia has similar safety profile to placebo with pharmacokinetics sufficient for weekly administration
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