Simulating the Multi-Epoch Direct Detection Technique to Isolate the Thermal Emission of the Non-Transiting Hot Jupiter HD187123B

We report the 6.5$\sigma$ detection of water from the hot Jupiter HD187123b with a Keplerian orbital velocity $K_p$ of 53 $\pm$ 13 km/s. This high confidence detection is made using a multi-epoch, high resolution, cross correlation technique, and corresponds to a planetary mass of 1.4$^{+0.5}_{-0.3}$ $M_J$ and an orbital inclination of 21 $\pm$ 5$^{\circ}$. The technique works by treating the planet/star system as a spectroscopic binary and obtaining high signal-to-noise, high resolution observations at multiple points across the planet's orbit to constrain the system's binary dynamical motion. All together, seven epochs of Keck/NIRSPEC $L$-band observations were obtained, with five before the instrument upgrade and two after. Using high resolution SCARLET planetary and PHOENIX stellar spectral models, along with a line-by-line telluric absorption model, we were able to drastically increase the confidence of the detection by running simulations that could reproduce, and thus remove, the non-random structured noise in the final likelihood space well. The ability to predict multi-epoch results will be extremely useful for furthering the technique. Here, we use these simulations to compare three different approaches to combining the cross correlations of high resolution spectra and find that the Zucker 2003 log(L) approach is least affected by unwanted planet/star correlation for our HD187123 data set. Furthermore, we find that the same total S/N spread across an orbit in many, lower S/N epochs rather than fewer, higher S/N epochs could provide a more efficient detection. This work provides a necessary validation of multi-epoch simulations which can be used to guide future observations and will be key to studying the atmospheres of further separated, non-transiting exoplanets.Comment: Accepted to AJ, 14 pages, 10 figure

Detection of Water Vapor in the Thermal Spectrum of the Non-Transiting Hot Jupiter upsilon Andromedae b

The upsilon Andromedae system was the first multi-planet system discovered orbiting a main sequence star. We describe the detection of water vapor in the atmosphere of the innermost non-transiting gas giant ups~And~b by treating the star-planet system as a spectroscopic binary with high-resolution, ground-based spectroscopy. We resolve the signal of the planet's motion and break the mass-inclination degeneracy for this non-transiting planet via deep combined flux observations of the star and the planet. In total, seven epochs of Keck NIRSPEC $L$ band observations, three epochs of Keck NIRSPEC short wavelength $K$ band observations, and three epochs of Keck NIRSPEC long wavelength $K$ band observations of the ups~And~system were obtained. We perform a multi-epoch cross correlation of the full data set with an atmospheric model. We measure the radial projection of the Keplerian velocity ($K_P$ = 55 $\pm$ 9 km/s), true mass ($M_b$ = 1.7 $^{+0.33}_{-0.24}$ $M_J$), and orbital inclination \big($i_b$ = 24 $\pm$ 4$^{\circ}$\big), and determine that the planet's opacity structure is dominated by water vapor at the probed wavelengths. Dynamical simulations of the planets in the ups~And~system with these orbital elements for ups~And~b show that stable, long-term (100 Myr) orbital configurations exist. These measurements will inform future studies of the stability and evolution of the ups~And~system, as well as the atmospheric structure and composition of the hot Jupiter.Comment: Accepted to A

Ground- and Space-based Detection of the Thermal Emission Spectrum of the Transiting Hot Jupiter KELT-2Ab

We describe the detection of water vapor in the atmosphere of the transiting hot Jupiter KELT-2Ab by treating the star-planet system as a spectroscopic binary with high-resolution, ground-based spectroscopy. We resolve the signal of the planet's motion with deep combined flux observations of the star and the planet. In total, six epochs of Keck NIRSPEC $L$-band observations were obtained, and the full data set was subjected to a cross correlation analysis with a grid of self-consistent atmospheric models. We measure a radial projection of the Keplerian velocity, $K_P$, of 148 $\pm$ 7 km s$^{-1}$, consistent with transit measurements, and detect water vapor at 3.8$\sigma$. We combine NIRSPEC $L$-band data with $Spitzer$ IRAC secondary eclipse data to further probe the metallicity and carbon-to-oxygen ratio of KELT-2Ab's atmosphere. While the NIRSPEC analysis provides few extra constraints on the $Spitzer$ data, it does provide roughly the same constraints on metallicity and carbon-to-oxygen ratio. This bodes well for future investigations of the atmospheres of non-transiting hot Jupiters.Comment: accepted to A

Evidence for the Direct Detection of the Thermal Spectrum of the Non-Transiting Hot Gas Giant HD 88133 b

We target the thermal emission spectrum of the non-transiting gas giant HD 88133 b with high-resolution near-infrared spectroscopy, by treating the planet and its host star as a spectroscopic binary. For sufficiently deep summed flux observations of the star and planet across multiple epochs, it is possible to resolve the signal of the hot gas giant's atmosphere compared to the brighter stellar spectrum, at a level consistent with the aggregate shot noise of the full data set. To do this, we first perform a principal component analysis to remove the contribution of the Earth's atmosphere to the observed spectra. Then, we use a cross-correlation analysis to tease out the spectra of the host star and HD 88133 b to determine its orbit and identify key sources of atmospheric opacity. In total, six epochs of Keck NIRSPEC L band observations and three epochs of Keck NIRSPEC K band observations of the HD 88133 system were obtained. Based on an analysis of the maximum likelihood curves calculated from the multi-epoch cross correlation of the full data set with two atmospheric models, we report the direct detection of the emission spectrum of the non-transiting exoplanet HD 88133 b and measure a radial projection of the Keplerian orbital velocity of 40 $\pm$ 15 km/s, a true mass of 1.02$^{+0.61}_{-0.28}M_J$, a nearly face-on orbital inclination of 15${^{+6}_{-5}}^{\circ}$, and an atmosphere opacity structure at high dispersion dominated by water vapor. This, combined with eleven years of radial velocity measurements of the system, provides the most up-to-date ephemeris for HD 88133.Comment: 9 pages, 6 figures; accepted for publication in Ap

Contrast and Temperature Dependence of Multi-Epoch High-Resolution Cross-Correlation Exoplanet Spectroscopy

While high-resolution cross-correlation spectroscopy (HRCCS) techniques have proven effective at characterizing the atmospheres of transiting and non-transiting hot Jupiters, the limitations of these techniques are not well understood. We present a series of simulations of one HRCCS technique, which combines the cross-correlation functions from multiple epochs, to place temperature and contrast limits on the accessible exoplanet population for the first time. We find that planets approximately Saturn-size and larger within ∼0.2 AU of a Sun-like star are likely to be detectable with current instrumentation in the L-band, a significant expansion compared with the previously-studied population. Cooler (T_(eq) ≤ 1000 K) exoplanets are more detectable than suggested by their photometric contrast alone as a result of chemical changes which increase spectroscopic contrast. The L-band CH₄ spectrum of cooler exoplanets enables robust constraints on the atmospheric C/O ratio at T_(eq)∼900K, which have proven difficult to obtain for hot Jupiters. These results suggest that the multi-epoch approach to HRCCS can detect and characterize exoplanet atmospheres throughout the inner regions of Sun-like systems with existing high-resolution spectrographs. We find that many epochs of modest signal-to-noise (S/N_(epoch)∼1500) yield the clearest detections and constraints on C/O, emphasizing the need for high-precision near-infrared telluric correction with short integration times

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which Accepted Article This article is protected by copyright. All rights reserved. are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target

Low-frequency ventilation during cardiopulmonary bypass for lung protection:A randomized controlled trial

OBJECTIVE: Pulmonary dysfunction is a common complication in patients undergoing heart surgery. Current clinical practice does not include any specific strategy for lung protection. To compare the anti-inflammatory effects of low-frequency ventilation (LFV), as measured by nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) p65 pathway activation, for the entire cardiopulmonary bypass (CPB) vs both lungs left collapsed in patients undergoing coronary artery bypass grafting (CABG). METHODS: Two groups parallel randomized controlled trial. The primary outcome was inflammation measured by NF-κB p65 activation in pre- and post-CPB lung biopsies. Secondary outcomes were additional inflammatory markers in both biopsy tissue and blood. RESULTS: Thirty-seven patients were randomly allocated to LFV (18) and to both lungs left collapsed (19). The mean concentration of NF-κB p65 in the biopsies before chest closure (adjusted for pre-CPB concentration) was higher in the LFV group compared to both lungs left collapsed group but this was not significant (0.102, 95% confidence interval, -0.022 to 0.226, P = 0.104). There were no significant differences between groups in the other inflammatory markers measured in tissue and blood. CONCLUSIONS: In patients undergoing elective CABG, the use of LFV during CPB when compared to both lungs left collapsed does not seem to reduce inflammation in lung biopsies and blood