Prendre le temps d'apprendre le temps aux enfants. Les travaux d'une chercheuse à l'ULB

Montres et réveils, horaires chargés des parents, récréations minutées et sonneries ponctuelles rythment la journée des enfants. A l'ère de l'urgence et de l'immédiat, notre temps est encombré. Et donc, le leur également. Lotta De Coster, psychologue et chercheuse à l'ULB, explique comment les aider à "apprendre le temps".Article rédigé par Christophe Lo Giudice. Interview avec Lotta De Coster.info:eu-repo/semantics/publishe

The antitumour activity of diorganotin(IV) complexes with adenine and glycylglycine

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The antitumor activity of di-n-butyltin(IV) glycylglycinate, and the correlation with the structure of dialkyltin(IV) glycylglycinates in solution

The in vivo activity of Bu2nSnGlyGly, Na(CI2GaGlyGly), and CIGaGlyGly (GlyGly2-- = glycylglycinate) has been investigated in connection with a number of tumors. Positive results have been obtained only for the Bu2nSnIV complex in the case of leukemia P-388 In order to try to interpret the pharmacological data on a molecular basis, the nature of the species present in solutions of AIK2Sn GlyGly complexes, as well as the reactivity of aqueous Me2SnGlyGly, have been studied. The presence of chelated species (I), Figure 1, in organic solvents, and the equilibrium (I) ⇌ (II), Figure 1, in water and mixed water-organic solvent systems, have been inferred from conductance measurements, as well as from studies by Mössbauer (in frozen solution), 1H, 13C, and 119Sn NMR, and ir spectroscopy. Moreover, solvated (II) would release AlK2SnIV moieties, as evidenced by the slow formation of (Me2SnO)n from aqueous Me2Sn GlyGly. The involvement of (I) and (II) in the transportation of these drugs across cell membranes is discussed. © 1985.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Marie-Soleil Frère racontée par ses collègues du Département des sciences de l’information et de la communication de l’ULB

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