Evolution of neoadjuvant chemotherapy in locally advanced HER2-positive breast cancer over 10 years in Hong Kong

Poster Presentation 2 - Breast Cancer: no. 71PThis journal suppl. entitled: ESMO Asia Congress, 18-21 December 2015, SingaporeAIM/BACKGROUND: Over the last 10 years we witnessed major changes in treatment for locally advanced HER2-positive breast cancer. The emergence of multiple anti-HER2 therapies and recognition of pathological complete response (pCR) as the surrogate marker for survival are the major landmarks. The clinical benefit of this approach and effects on patient behaviour in Asian countries has not been reported. METHODS: This retrospective study summarizes the changes in practice and outcome during the period 2005 to 2015 from a tertiary referral center in Hong Kong. Patients were divided into 3 groups according to the NAC they received: chemotherapy only (CH), chemotherapy plus trastuzumab (CH-H), and chemotherapy plus double anti- HER2 therapies (CH-DH). RESULTS: There were 177 patients captured during this period and significantly more pre-menopausal women in the groups receiving anti-HER2 therapies (*p < 0.01). Rate of pCR was higher in patients who received anti-HER2 therapies (*p < 0.01), with patients in CH-DH group had more pCR than those in CH-H group (**p < 0.01). This was accompanied by a trend in increase rate of breast conservation therapy (BCT). The estimated recurrent-free-survival (censored) at 5 years was 57% (CH), 76% (CH-H), and 93% (CH-DH) respectively with a mean follow up of 4.2 years. Longer follow up would be required for conclusive results. CONCLUSIONS: Current approach of NAC using CH-H and CH-DH appeared to derive similar favourable pCR rate in Asian patients compared with published results. The option of BCT after the enhanced tumor shrinkage achieved with NAC may explain the preference of NAC in HER-positive premenopausal women. Combination NAC with double anti-HER2 therapy is likely to become the preferred option to achieve higher BCT rates.link_to_OA_fulltex

The New Era of e-Learning Volume II - Interactive Learning and Assessment for Learning

The book can be viewed at: http://www.engineering.hku.hk/enggke/ebook/elearning2_en.pdf1st Edition: 2014A book introduce the new trend in e-learning and publsihed cases of innovative pedagogy and technology in interactive teaching in HKU, HK and mainland

Risk factors for child physical abuse and neglect among Chinese young mothers

Although studies have reported a linkage between young pregnancy and child maltreatment risk, it is still unclear about what factors place young mothers at greater risk of maltreating their child in Chinese context. Based on the socio-ecological model, risk factors in 4 domains: family background/structure, maternal stressors, mother-child interaction, and child behavioral issue in relation to physical assault, neglect, both physical assault and neglect, and either physical assault or neglect among Chinese young mothers in Hong Kong were assessed. 392 young mothers were recruited from an integrated supportive program for young mothers. The mean age of mothers at delivery was 21.8 (SD = 3.0) and 52.3% were married. Individual risk factors and cumulative risk domains related to different child maltreatment groups were examined. Our results show both overlapping and unique risk factors across the domains associated with physical assault and neglect. Further, young families exposed to higher number of risk domains show higher rates for physical assault and neglect, co-occurrence of physical assault and neglect, and either form of maltreatment. In addition, various risk domains were found to be particularly important for different forms of maltreatment: family background/structure domain was found to be an important risk domain for neglect; mother-child interaction domain for both physical assault and neglect; family background/structure and maternal stressors domains for either physical assault or neglect. Closer examination of a subgroup of adolescent mothers aged 18 and below shows that family background/structure was an important risk domain for this group.Department of Applied Social Science

Risk factors for child physical abuse and neglect among Chinese young mothers

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