33 research outputs found

    The Contribution of Ageing to Hospitalisation Days in Hong Kong: A Decomposition Analysis

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    Influence of Maternal Infection and Pregnancy Complications on Cord Blood Telomere Length

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    BACKGROUND: Exposure to suboptimal intrauterine environment might induce structural and functional changes that can affect neonatal health. Telomere length as an important indicator of cellular health has been associated with increased risk for disease development. OBJECTIVES: This study was aimed to examine the independent and combined effects of maternal, obstetric, and foetal factors on cord blood telomere length (TL). METHODS: Pregnant women at the gestational age of 20th to 24th week who attended the antenatal clinic of a major local hospital in Hong Kong were recruited. Participants were asked to complete a questionnaire on demographics, health-related quality of life, and history of risk behaviors. Medical history including pregnancy complications and neonatal outcomes was obtained from electronic medical records of both mother and neonate. Umbilical cord blood was collected at delivery for TL determination. RESULTS: A total of 753 pregnant women (average age: 32:18 ± 4:51 years) were recruited. The prevalence of maternal infection, anaemia, and hypertension during pregnancy was 30.8%, 30.0%, and 6.0%, respectively. The adjusted regression model displayed that maternal infection was negatively associated with cord blood TL (β = −0:18, p = 0:026). This association became even stronger in the presence of antenatal anaemia, hypertension, delivery complications, or neonatal jaundice (β = −0:25 to −0.45). Conclusions. This study consolidates evidence on the impact of adverse intrauterine environment at the cellular level. Maternal infection was significantly associated with shorter cord blood TL in a unique manner such that its presence may critically determine the susceptibility of telomere to other factors

    The effectiveness of parenting programs in regard to improving parental reflective functioning : a meta-analysis

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    202305 bcwwAccepted ManuscriptOthersThe Hong Kong Polytechnic UniversityPublishe

    Community-based interventions to reduce child maltreatment

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    202305 bcwwAccepted ManuscriptOthersThe Hong Kong Polytechnic UniversityPublishe

    Evaluating the portfolio as a social work capstone project: a case study in Hong Kong

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    202208 bcrcOthersThe Hong Kong Polytechnic University, Educational Development CentreEarly release12 month

    Association between childhood exposure to family violence and telomere length : a meta-analysis

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    202307 bcchVersion of RecordRGCOthersHong Kong Polytechnic UniversityPublishe

    The occurrence and co-occurrence of harsh parenting and family conflict in Hong Kong

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    202307 bcchVersion of RecordRGCOthersHome Affairs Bureau of the Government of the Hong Kong Special Administrative RegionPublishe

    Screening for multiple types of family violence : development and validation of the family polyvictimization screen

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    202001 bcmaVersion of RecordRGCPolyU37000316Publishe
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