Promotion of collaboration between medical and dental professionals

Includes bibliographical references (p. 25-26).published_or_final_versio

Selective versus non-selective suppression of nitric oxide synthase on regional hemodynamics in rats with or without LPS-induced endotoxemia

The late phase of severe septic shock is associated with reduced cardiac output (CO) and activation of the inducible isoform of nitric oxide synthase (NOS). This study examined the effects of 1400 W (N-3-aminomethylbenzyl-acetamidine), a new selective inhibitor of inducible NOS (iNOS), relative to those of NG-nitro-L-arginine (L-NNA, non-selective inhibitor of NOS) and the vehicle, on mean arterial pressure (MAP), CO, total peripheral resistance (TPR) and tissue blood flow (BF) in thiobutabarbital-anesthetized rats with lipopolysaccharide (LPS, 10 mg/kg, i.v.) induced endotoxemia. At 2.5 as well as 4h after injection of LPS, MAP, CO, and BF of the stomach, skeletal muscle and skin were decreased, but TPR was increased, BF to the heart and kidneys were also decreased at 4 h after injection of LPS. Treatment of endotoxemic rats with 1400W (3 mg/kg followed by 3 mg/kg/h, i.v.) at 2.5 h after endotoxin challenge prevented the late phase fall in MAP without exacerbating the decreases in CO and tissue BF. In contrast, treatment with L-NNA (8mg/kg followed by 3 mg/kg/h, i.v.) at 2.5 h did not prevent the decline in MAP in the LPS-treated rats. Furthermore, CO drastically decreased, TPR markedly increased, and BF to the heart, brain, intestine and skeletal muscle were decreased at 4 h relative to the readings in saline- or 1400 W-treated endotoxemic rats. Therefore, selective inhibition of iNOS by 1400 W restores MAP without compromising CO, but non-selective inhibition of NOS is detrimental at the late stage of septic shock.link_to_subscribed_fulltex

The Library of Hong Kong Society for the Blind

The Information Accessibility Centre (IAC) of the Hong Kong Society for the Blind (HKSB) is the only library that provides information and library services to the visually impaired people in Hong Kong. It plays a vital role in helping its HKSB members to obtain information and reading materials, thereby fulfilling their recreational reading needs, as well as to explore the world, while the supports provided by the local public libraries are very limited. In the following interview, Fung-kam Chung (Senior Library Assistant, HKSB) explains in detail, the unique collections, services, as well as other recreational activities that are tailor-made for the visually impaired people, as well as the hard work and patience that is involved for working as a library professional for the HKSB.link_to_OA_fulltex

Integrating functional analysis in the next-generation sequencing diagnostic pipeline of RASopathies

2017-2018 > Academic research: refereed > Publication in refereed journal201808 bcrcVersion of RecordPublishe