Effectiveness of sensory modulation in treating sensory modulation disorders in adults with schizophrenia: a Systematic Literature Review

Sensory modulation, as a treatment for sensory modulation disorders in adults with psychiatric conditions, has been implemented by occupational therapists for more than two decades. The purpose of this systematic literature review was to evaluate published research evidence relating to this intervention. The aim of the study was to determine if there was established evidence for the effectiveness of sensory modulation in treating sensory modulation disorder in adults with schizophrenia and to identify any gaps in knowledge to guide further research. We utilized Australia’s National Health and Medical Research Council (NHMRC)’s levels of evidence and recommendation grading and the Rosalind Franklin Research Appraisal Instrument (RF-QRA) to review selected articles. The results were then summarized and reported utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework. A total of 17 studies were included in the study. We concluded that there is preliminary evidence for the existence of sensory modulation disorder in schizophrenia and the effectiveness of sensory modulation interventions for reducing distress. We recommended further studies on the effectiveness of sensory modulation with better rigor and advise that guidelines be developed for use in practice by clinicians.Griffith Health, School of Applied PsychologyNo Full Tex

Mechanistic understanding of the rotating membrane emulsification process towards the development of design and scale-up theory

The effect of processing and formulation parameters on the resulting oil-in-water, emulsion microstructure has been studied for a recently developed process; rotating membrane emulsification. A broad range of surfactant and particle dispersions were explored to reveal the key drivers that determine the final droplet size produced. The aim of the study was to understand initial droplet generation and therefore emulsion stability, whilst a significant element in emulsification studies, is not considered here. By furthering the understanding of the processing mechanisms involved, this enabled development of theoretical models to estimate droplet size and extent of coalescence from first principles. In addition, the implications of process scale-up were studied. From this work, the very first design procedure for rotating membrane emulsification was derived and proposed. The final emulsion microstructure is heavily dependent on the coupled interaction between the fluid flow behaviour of the two phases and interfacial phenomena. Careful selection of process parameters based on sufficient characterisation of properties such as interfacial tension and viscosity, can avoid the occurrence of droplet coalescence or dispersed phase jetting. These can have a detrimental effect on producing a carefully controlled microstructure on a repeatable basis. Of particular importance is the rate of surfactant adsorption at the oil/water interface. A unique approach of dispersing non-ionic, high HLB surfactants such as Tween 20 and Brij 97 within the oil phase has been found to significantly reduce droplet size. This discovery allows the process to be highly competitive with a rotor-stator high shear mixer and an ultrasonic probe at a fraction of the energy consumption. Pilot-scale operation of rotating membrane emulsification provided important insight into how one might design and therefore implement the process for an industrial purpose. It is proposed here that a suitable scale-up parameter would be the membrane surface velocity

High-resolution broadband spectroscopy using externally dispersed interferometry at the Hale telescope: part 2, photon noise theory

High-resolution broadband spectroscopy at near-infrared (NIR) wavelengths (950 to 2450 nm) has been performed using externally dispersed interferometry (EDI) at the Hale telescope at Mt. Palomar, with the TEDI interferometer mounted within the central hole of the 200-in. primary mirror in series with the comounted TripleSpec NIR echelle spectrograph. These are the first multidelay EDI demonstrations on starlight. We demonstrated very high (10×) resolution boost and dramatic (20× or more) robustness to point spread function wavelength drifts in the native spectrograph. Data analysis, results, and instrument noise are described in a companion paper (part 1). This part 2 describes theoretical photon limited and readout noise limited behaviors, using simulated spectra and instrument model with noise added at the detector. We show that a single interferometer delay can be used to reduce the high frequency noise at the original resolution (1× boost case), and that except for delays much smaller than the native response peak half width, the fringing and nonfringing noises act uncorrelated and add in quadrature. This is due to the frequency shifting of the noise due to the heterodyning effect. We find a sum rule for the noise variance for multiple delays. The multiple delay EDI using a Gaussian distribution of exposure times has noise-to-signal ratio for photon-limited noise similar to a classical spectrograph with reduced slitwidth and reduced flux, proportional to the square root of resolution boost achieved, but without the focal spot limitation and pixel spacing Nyquist limitations. At low boost (∼1×) EDI has ∼1.4× smaller noise than conventional, and at >10× boost, EDI has ∼1.4× larger noise than conventional. Readout noise is minimized by the use of three or four steps instead of 10 of TEDI. Net noise grows as step phases change from symmetrical arrangement with wavenumber across the band. For three (or four) steps, we calculate a multiplicative bandwidth of 1.8:1 (2.3:1), sufficient to handle the visible band (400 to 700 nm, 1.8:1) and most of TripleSpec (2.6:1)

Nutrient recycling facilitates long-term stability of marine microbial phototroph–heterotroph interactions

Biological interactions underpin the functioning of marine ecosystems, be it via competition, predation, mutualism or symbiosis processes. Microbial phototroph–heterotroph interactions propel the engine that results in the biogeochemical cycling of individual elements, and they are critical for understanding and modelling global ocean processes. Unfortunately, studies thus far have focused on exponentially growing cultures in nutrient-rich media, meaning knowledge of such interactions under in situ conditions is rudimentary at best. Here, we have performed long-term phototroph–heterotroph co-culture experiments under nutrient-amended and natural seawater conditions, and show that it is not the concentration of nutrients but rather their circulation that maintains a stable interaction and a dynamic system. Using the Synechococcus–Roseobacter interaction as a model phototroph–heterotroph case study, we show that although Synechococcus is highly specialized for carrying out photosynthesis and carbon fixation, it relies on the heterotroph to remineralize the inevitably leaked organic matter, making nutrients circulate in a mutualistic system. In this sense we challenge the general belief that marine phototrophs and heterotrophs compete for the same scarce nutrients and niche space, and instead suggest that these organisms more probably benefit from each other because of their different levels of specialization and complementarity within long-term stable-state systems

Raman spectroscopy of ion irradiated SiC: chemical defects, strain, annealing, and oxidation

Raman spectroscopy has been used to identify defective bonding in neon and silicon ion irradiated single crystals of 6H-SiC. Observable differences exist in the C-C bonding region corresponding to different defect structures for neon and silicon ion implantations. Raman spectra of ion irradiated SiC show less tensile strain than neutron irradiations, explained by a residual compressive stress caused by the swelling constrained by the undamaged substrate. Evidence of oxidation during high temperature ion implantation is observed as C-O and Si-O Raman signals. Annealing irradiated SiC while acquiring Raman spectra shows rapid recovery of Si-C bonding, but not a complete recovery of the unirradiated structure. Annealing irradiated SiC causes surface oxidation where unirradiated SiC does not oxidise. Comparisons are made to the apparent radiation resistance of diamond and silicon which have similar crystal structures, but are monatomic, leading to the suggestion that chemical defects are responsible for increased radiation damage in SiC.Comment: 24 pages, 8 figure

TEDI: the TripleSpec Exoplanet Discovery Instrument

The TEDI (TripleSpec - Exoplanet Discovery Instrument) will be the first instrument fielded specifically for finding low-mass stellar companions. The instrument is a near infra-red interferometric spectrometer used as a radial velocimeter. TEDI joins Externally Dispersed Interferometery (EDI) with an efficient, medium-resolution, near IR (0.9 - 2.4 micron) echelle spectrometer, TripleSpec, at the Palomar 200" telescope. We describe the instrument and its radial velocimetry demonstration program to observe cool stars.Comment: 6 Pages, To Appear in SPIE Volume 6693, Techniques and Instrumentation for Detection of Exoplanets II