Induced Stem Cells as a Novel Multiple Sclerosis Therapy.

Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or mesenchymal stem cells is a potential therapy for MS thanks to their capacity for cell repopulation as well as for their immunomodulatory and neurotrophic properties. Induced pluripotent stem cell (iPSC), an emerging cell source in regenerative medicine, is also being tested for the treatment of MS. Remarkable improvement in mobility and robust remyelination have been observed after transplantation of iPSC-derived neural cells into demyelinated models. Direct reprogramming of somatic cells into induced neural cells, such as induced neural stem cells (iNSCs) and induced oligodendrocyte progenitor cells (iOPCs), without passing through the pluripotency stage, is an alternative for transplantation that has been proved effective in the congenital hypomyelination model. iPSC technology is rapidly progressing as efforts are being made to increase the efficiency of iPSC therapy and reduce its potential side effects. In this review, we discuss the recent advances in application of stem cells, with particular focus on induced stem/progenitor cells (iPSCs, iNSC, iOPCs), which are promising in the treatment of MS

Chaotic Attitude Motion of a Class of Spacecraft on an Elliptic Orbit

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Inhibition of hepatocelluar carcinoma MAT2A and MAT2beta gene expressions by single and dual small interfering RNA

RNA interference (RNAi) has been successfully applied in suppression of hepatic cancer genes. In hepatocelluar carcinoma cell, one methionine adenosyltransferase (MAT) isozyme, MATII was found to have two catalytic subunits which were encoded by MAT2A and MAT2β respectively. During tumorigeness of hepatocelluar carcinoma, expressions of the two genes were discovered to be increased combining with a switch of MAT (form MATI to MATII), To figure out the role played by MATII in hepatic cancer, In this study, for the first time we established a dual small interfering RNA (siRNA) expression system, which could simultaneously express two different siRNA molecules specifically targeting two genes. To test the effectiveness of this system, we applied this approach to express simultaneously two different siRNA duplexes that specifically target MAT2A and MAT2β genes of hepatocelluar carcinoma respectively in HepG2 cell. Results indicated that dual siRNA could simultaneously inhibit the expression of MAT2A and MAT2β gene by 89.5% and 97.8% respectively, In addition, dual siRNA molecules were able to significantly suppress growth of hepatocelluar carcinoma cell in vitro as well as induce apoptosis which was involved in arrest cell cycle at the G1/S checkpoint and the expressions of p21, p27 and Bax

Optimum nonuniform transmultiplexer design

This paper considers an optimum nonuniform FIR transmultiplexer design subject to specifications in the frequency domain. Our objective is to minimize the sum of the ripple energy for all the individual filters, subject to the specifications on amplitude and aliasing distortions, and to the passband and stopband specifications for the individual filters. This optimum nonuniform transmultiplexer design problem can be formulated as a quadratic semi-infinite programming problem. The dual parametrization algorithm is extended to the design of this nonuniform transmultiplexer problem. If the lengths of the filters are sufficiently long and the set of decimation integers is compatible, then our algorithm guarantees that the solution obtained will give rise to the global minimum, and the required specifications are satisfied

SongRewriter: A Chinese Song Rewriting System with Controllable Content and Rhyme Scheme

Although lyrics generation has achieved significant progress in recent years, it has limited practical applications because the generated lyrics cannot be performed without composing compatible melodies. In this work, we bridge this practical gap by proposing a song rewriting system which rewrites the lyrics of an existing song such that the generated lyrics are compatible with the rhythm of the existing melody and thus singable. In particular, we propose SongRewriter, a controllable Chinese lyric generation and editing system which assists users without prior knowledge of melody composition. The system is trained by a randomized multi-level masking strategy which produces a unified model for generating entirely new lyrics or editing a few fragments. To improve the controllabiliy of the generation process, we further incorporate a keyword prompt to control the lexical choices of the content and propose novel decoding constraints and a vowel modeling task to enable flexible end and internal rhyme schemes. While prior rhyming metrics are mainly for rap lyrics, we propose three novel rhyming evaluation metrics for song lyrics. Both automatic and human evaluations show that the proposed model performs better than the state-of-the-art models in both contents and rhyming quality. Our code and models implemented in MindSpore Lite tool will be available

Search for the Contamination Source of Butyltin Compounds in Wine: Agglomerated Cork Stoppers

A possible butyltin contamination source in wine was studied in this paper. Agglomerated cork stoppers, which were produced in Portugal, Spain, and Italy, used in wine bottles were examined. The domestic cork products, cork granules, and mucus used for cork products were also analyzed. The levels of mono- and dibutyltin compounds in corks were found in the range from <0.0024 to 3.3 and from <0.0029 to 6.7 mug of Sn/g, respectively. A low level of tributyltin contamination was also found in 2 of 31 tested samples. The presence of butyltin compounds in agglomerated cork stoppers was confirmed by GC-MS. Experimental results indicated that all overseas agglomerated cork stoppers studied contained mono- and/or dibutyltins. Butyltins were not detected in cork granules, mucus, most of the natural cork stoppers, and domestic agglomerated cork products. The concentrations of mono- and dibutyltins increased with the time in a 30-day experiment, showing that butyltin compounds can leach from agglomerated cork to the wine. When the butyltin concentrations in wine samples were compared with their levels in the corresponding agglomerated cork stoppers, a correlation was found. The potential harm of such food contamination was evaluated by the toxic research of butyltin compounds using Daphnia sp. as the experimental model

Optimal design of nonuniform FIR transmultiplexer using semi-infinite programming

This paper considers an optimum nonuniform FIR transmultiplexer design problem subject to specifications in the frequency domain. Our objective is to minimize the sum of the ripple energy for all the individual filters, subject to the specifications on amplitude and aliasing distortions, and to the passband and stopband specifications for the individual filters. This optimum nonuniform transmultiplexer design problem can be formulated as a quadratic semi-infinite programming problem. The dual parametrization algorithm is extended to this nonuniform transmultiplexer design problem. If the lengths of the filters are sufficiently long and the set of decimation integers is compatible, then a solution exists. Since the problem is formulated as a convex problem, if a solution exists, then the solution obtained is unique and the local solution is a global minimum

Optimal PWM control of switched-capacitor DC/DC power converters via model transformation and enhancing control techniques

Abstract—This paper presents an efficient and effective method for an optimal pulse width modulated (PWM) control of switched-capacitor DC/DC power converters. Optimal switching instants are determined based on minimizing the output ripple magnitude, the output leakage voltage and the sensitivity of the output load voltage with respect to both the input voltage and the load resistance. This optimal PWM control strategy has several advantages over conventional PWM control strategies: 1) It does not involve a linearization, so a large signal analysis is performed. 2) It guarantees the optimality. The problem is solved via both the model transformation and the optimal enhancing control techniques. A practical example of the PWM control of a switched-capacitor DC/DC power converter is presented

Fuzzy switching systems: minimizing discontinuities and ripple magnitude and energy

This paper presents an efficient and effective method to determine optimal switching instants of fuzzy switching systems such that both the ripple magnitude and energy of the fuzzy switching systems are minimized. The method is based on optimal switching control techniques, where an optimal enhancing control method is used. This method has several advantages over the traditional methods. Firstly, it does not require the process of linearization. Secondly, it guarantees to achieve optimality. For illustration, a practical example of an optimal pulse width modulated fuzzy control of a switched-capacitor DC/DC power converter is presented