Preparation and Characterization of Self-Assembled Nanoparticles of Hyaluronic Acid-Deoxycholic Acid Conjugates

Novel amphiphilic biopolymers were synthesized using hyaluronic acid (HA) as a hydrophilic segment and deoxycholic acid (DOCA) as a hydrophobic segment by a 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide mediated coupling reaction. The structural characteristics of the HA-DOCA conjugates were investigated using H1 NMR. Self-assembled nanoparticles were prepared based on HA-DOCA conjugates, and its characteristics were investigated using dynamic laser light scattering, transmission electron microscopy (TEM), and fluorescence spectroscopy. The mean diameter was about 293.5 nm with unimodal size distribution in distilled water. The TEM images revealed that the shape of HA-DOCA self-aggregates was spherical. The critical aggregation concentration (CAC) was in the range of 0.025–0.056 mg/mL. The partition equilibrium constant (Kv) of pyrene in self-aggregates solution was from 1.45×104 to 3.64×104. The aggregation number of DOCA groups per hydrophobic microdomain, estimated by the fluorescence quenching method using cetylpyridinium chloride, increased with increasing degree of substitution

Deep Learning-empowered Predictive Precoder Design for OTFS Transmission in URLLC

To guarantee excellent reliability performance in ultra-reliable low-latency communications (URLLC), pragmatic precoder design is an effective approach. However, an efficient precoder design highly depends on the accurate instantaneous channel state information at the transmitter (ICSIT), which however, is not always available in practice. To overcome this problem, in this paper, we focus on the orthogonal time frequency space (OTFS)-based URLLC system and adopt a deep learning (DL) approach to directly predict the precoder for the next time frame to minimize the frame error rate (FER) via implicitly exploiting the features from estimated historical channels in the delay-Doppler domain. By doing this, we can guarantee the system reliability even without the knowledge of ICSIT. To this end, a general precoder design problem is formulated where a closed-form theoretical FER expression is specifically derived to characterize the system reliability. Then, a delay-Doppler domain channels-aware convolutional long short-term memory (CLSTM) network (DDCL-Net) is proposed for predictive precoder design. In particular, both the convolutional neural network and LSTM modules are adopted in the proposed neural network to exploit the spatial-temporal features of wireless channels for improving the learning performance. Finally, simulation results demonstrated that the FER performance of the proposed method approaches that of the perfect ICSI-aided scheme.Comment: 8 pages, 6 figure

Predictive Precoder Design for OTFS-Enabled URLLC: A Deep Learning Approach

This paper investigates the orthogonal time frequency space (OTFS) transmission for enabling ultra-reliable low-latency communications (URLLC). To guarantee excellent reliability performance, pragmatic precoder design is an effective and indispensable solution. However, the design requires accurate instantaneous channel state information at the transmitter (ICSIT) which is not always available in practice. Motivated by this, we adopt a deep learning (DL) approach to exploit implicit features from estimated historical delay-Doppler domain channels (DDCs) to directly predict the precoder to be adopted in the next time frame for minimizing the frame error rate (FER), that can further improve the system reliability without the acquisition of ICSIT. To this end, we first establish a predictive transmission protocol and formulate a general problem for the precoder design where a closed-form theoretical FER expression is derived serving as the objective function to characterize the system reliability. Then, we propose a DL-based predictive precoder design framework which exploits an unsupervised learning mechanism to improve the practicability of the proposed scheme. As a realization of the proposed framework, we design a DDCs-aware convolutional long short-term memory (CLSTM) network for the precoder design, where both the convolutional neural network and LSTM modules are adopted to facilitate the spatial-temporal feature extraction from the estimated historical DDCs to further enhance the precoder performance. Simulation results demonstrate that the proposed scheme facilitates a flexible reliability-latency tradeoff and achieves an excellent FER performance that approaches the lower bound obtained by a genie-aided benchmark requiring perfect ICSI at both the transmitter and receiver.Comment: 31 pages, 12 figure

Scalable Predictive Beamforming for IRS-Assisted Multi-User Communications: A Deep Learning Approach

Beamforming design for intelligent reflecting surface (IRS)-assisted multi-user communication (IRS-MUC) systems critically depends on the acquisition of accurate channel state information (CSI). However, channel estimation (CE) in IRS-MUC systems causes a large signaling overhead for training due to the large number of IRS elements. In this paper, taking into account user mobility, we adopt a deep learning (DL) approach to implicitly learn the historical line-of-sight (LoS) channel features and predict the IRS phase shifts to be adopted for the next time slot for maximization of the weighted sum-rate (WSR) of the IRS-MUC system. With the proposed predictive approach, we can avoid full-scale CSI estimation and facilitate low-dimensional CE for transmit beamforming design such that the signaling overhead is reduced by a scale of $\frac{1}{N}$, where $N$ is the number of IRS elements. To this end, we first develop a universal DL-based predictive beamforming (DLPB) framework featuring a two-stage predictive-instantaneous beamforming mechanism. As a realization of the developed framework, a location-aware convolutional long short-term memory (CLSTM) graph neural network (GNN) is developed to facilitate effective predictive beamforming at the IRS, where a CLSTM module is first adopted to exploit the spatial and temporal features of the considered channels and a GNN is then applied to empower the designed neural network with high scalability and generalizability. Furthermore, in the second stage, based on the predicted IRS phase shifts, an instantaneous CSI-aware fully-connected neural network is designed to optimize the transmit beamforming at the access point. Simulation results demonstrate that the proposed framework not only achieves a better WSR performance and requires a lower CE overhead compared with state-of-the-art benchmarks, but also is highly scalable in the numbers of users.Comment: 30 pages, 14 figures, journal pape