7,017 research outputs found
and : Candidates for charmed-strange mesons
Newly observed two charmed-strange resonances, and
, are investigated by calculating their Okubo-Zweig-Iizuka
allowed strong decays, which shows that they are suitable candidates for the
and states in the charmed-strange meson family. Our study
also predicts other main decay modes of and ,
which can be accessible at the future experiment. In addition, the decay
behaviors of the spin partners of and , i.e.,
and , are predicted in this work, which are still
missing at present. Experimental search for the missing and
charmed-strange mesons is an intriguing and challenging task
for further experiment.Comment: 8 pages, 3 figures and 4 tables. More discussions added and typos
corrected. Accepted by Eur. Phys. J.
Prp8 intein in fungal pathogens: target for potential antifungal drugs
AbstractInteins are self-splicing intervening sequences in proteins, and inteins of pathogenic organisms can be attractive drug targets. Here, we report an intein in important fungal pathogens including Aspergillus fumigatus, Aspergillus nidulans, Histoplasma capsulatum, and different serotypes of Cryptococcus neoformans. This intein is inside the extremely conserved and functionally essential Prp8 protein, and it varies in size from 170 aa in C. neoformans to 819 aa in A. fumigatus, which is caused by the presence or absence of an endonuclease domain and a putative tongs subdomain in the intein. Prp8 inteins of these organisms were demonstrated to do protein splicing in a recombinant protein in Escherichia coli. These findings revealed Prp8 inteins as attractive targets for potential antifungal drugs to be identified using existing selection and screening methods
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