DCTTS: Discrete Diffusion Model with Contrastive Learning for Text-to-speech Generation

In the Text-to-speech(TTS) task, the latent diffusion model has excellent fidelity and generalization, but its expensive resource consumption and slow inference speed have always been a challenging. This paper proposes Discrete Diffusion Model with Contrastive Learning for Text-to-Speech Generation(DCTTS). The following contributions are made by DCTTS: 1) The TTS diffusion model based on discrete space significantly lowers the computational consumption of the diffusion model and improves sampling speed; 2) The contrastive learning method based on discrete space is used to enhance the alignment connection between speech and text and improve sampling quality; and 3) It uses an efficient text encoder to simplify the model's parameters and increase computational efficiency. The experimental results demonstrate that the approach proposed in this paper has outstanding speech synthesis quality and sampling speed while significantly reducing the resource consumption of diffusion model. The synthesized samples are available at https://github.com/lawtherWu/DCTTS.Comment: 5 pages, submitted to ICASS

A Research on the Relationship between Intestinal Flora and Human Longevity

The exploration of human life and health is advancing with the changes of the times. With the growth of age, the occurrence of chronic diseases of human immunity and organ system is frequent, which has a serious impact on human health. Genes, environment and other random factors determine the outcome of longevity, and intestinal flora is considered to be a decisive factor affecting human health and longevity, mainly because of its huge impact on human immunity, growth and development. The study of the relationship between intestinal flora and longevity is beneficial to improve the health status of the elderly and improve the overall life level of human beings, which has great scientific research value. This review will review the role of intestinal flora in longevity

Initial Effects of Electroacupuncture for Chronic Severe Functional Constipation and the Potential Underlying Factors: Secondary Analysis of a Randomized Controlled Trial

Background. Electroacupuncture (EA) has been found to be effective for treating chronic severe functional constipation (CSFC). However, the initial effects of treatment usually affect the acceptability and compliance of patients with chronic disease in particular. Which class of CSFC patients will have a better initial response to EA remains uncertain and requires investigation. Methods. This was a secondary analysis of an original multicenter randomized controlled trial in which patients with CSFC were randomly assigned to receive 28 sessions of EA or sham electroacupuncture (SA) over 8 weeks with 12 weeks of follow-up. The primary outcome, namely, response with complete spontaneous bowel movements (CSBMs), required participants to have ≥ 3 CSBMs and an increase of ≥ 1 CSBM from the baseline over the first week of treatment. Logistic regression analysis with bootstrapping techniques was performed to determine independent factors related to the response. Results. A total of 1051 eligible patients were included in this study of whom 161 patients were classified as responders at week 1. The CSBM response rate was higher in the EA group (17.5%) than in the SA group (13.2%). And the proportion of these 1-week early responders remained to have higher clinical response at the end of 8-week treatment and 12 weeks after treatment. Age and higher baseline CSBMs were related to CSBM response within the first week: with every 1-year increase in age, the likelihood of clinical response was reduced by 1.7% (odds ratio [OR] 0.983, 95% confidence interval [CI] 0.972 to 0.993; P=0.001). The odds of a CSBM response in patients with 1< CSBMs ≤ 2 at baseline were 4.64 times higher than that in patients with CSBMs ≤ 1 (OR 4.64, 95%CI 4.01 to 5.27). Conclusions. EA produced its initial effects within the first week of treatment. And the effects could last until week 8 and week 20. A younger age and higher number of CSBMs at baseline may increase likelihood of a response

3D Cardiac Cell Culture on Nanofiber Bundle Substrates for the Investigation of Cell Morphology and Contraction

Cardiac failure is a quite severe condition that can result in life-threatening consequences. Cardiac tissue engineering is thought to be one of the most promising technologies to reconstruct damaged cardiac muscles and facilitate myocardial tissue regeneration. We report a new nanofiber bundle substrate for three-dimensional (3D) cardiac cell culture as a platform to investigate cell morphology and contraction. Polymeric nanofiber bundles with various patterns act as physical cues to align the cardiac cell sheets. Comparing the uniaxial alignment with the randomly distributed pattern, we found that the bundles with the former pattern have more “grooves” for the settlement of cardiomyocytes in a 3D structure than the latter. The cardiomyocytes loaded on the aligned nanofiber bundles tend to grow along the fiber axis. The interfacial structure between a single cardiomyocyte in the cardiac cell sheet and the attached nanofibers was observed using environmental scanning electron microscope. Immunofluorescence imaging showed that the uniaxially aligned nanofibers greatly promoted cell attachment and alignment of the cardiomyocytes because of the matching morphology between the nanofiber pattern and the biological components. Moreover, we concluded that the aligned polymeric nanofibers could be a promising substrate suitable for the anisotropic contraction of cardiac cell sheets

Mining Spectrum Usage Data: A Large-Scale Spectrum Measurement Study

Dynamic spectrum access has been a subject of extensive study in recent years. The increasing volume of literatures calls for a deeper understanding of the characteristics of current spectrum utilization. In this paper, we present a detailed spectrum measurement study, with data collected in the 20 MHz to 3 GHz spectrum band and at four locations concurrently in Guangdong province of China. We examine the statistics of the collected data, including channel vacancy statistics, channel utilization within each individual wireless service, and the spectral and spatial correlation of these measures. Main findings include that the channel vacancy durations follow an exponential-like distribution, but are not independently distributed over time, and that significant spectral and spatial correlations are found between channels of the same service. We then exploit such spectrum correlation to develop a 2D frequent pattern mining algorithm that can predict channel availability based on past observations with considerable accuracy

Thermal Analysis of a New Neutron Shielding Vacuum Multiple Glass

The neutron shielding glass is widely used in nuclear/fusion plants. To improve its temperature resistance and heat insulation, a Gadolinium (Gd)-containing laminate vacuum multiple glass is proposed by using the vacuum insulation method. A 3D finite element model validated by theoretical calculation was developed to analyse the heat transfer path and numerical simulation of the multiple glass was carried out to obtain the temperature distribution and the maximum temperatures of the organic glass in relation to dynamic working temperatures, the sealing agent width, view size, and vacuum thermal conductivity. The results show that the vacuum layer between common glasses can make the work temperature of neutron shielding glass increase. The multiple glass has good heat-shielding performance and it is expected to work in a high-temperature environment. In addition, the vacuum layer between the common glasses and the sealing agent width decay with respect to the view size and vacuum thermal conductivity show an increase in the working temperature of the neutron shielding glass. It was concluded that the order of affecting the temperatures of the organic glass follows the pattern of: view size &gt; vacuum thermal conductivity &gt; sealing agent width

Laser Sealing for Vacuum Plate Glass with PbO-TiO2-SiO2-RxOy Solder

Laser sealing for vacuum plate glass is a key step in developing the cost-effective smart vacuum-glass window for the drive towards net-zero energy buildings. In this paper, the pores, cracks, and interface with laser welding are analyzed in depth using PbO-TiO2-SiO2-RxOy system sealing solder to prepare vacuum flat glass. The microstructure of the sealing layer was analyzed by a BX41M-LED metallographic microscope, and the interfacial bonding characteristics were observed by thermal field emission scanning electron microscopy (SEM). The solder was analyzed by an energy spectrometer, and the influence of laser power, sealing temperature, and sealing speed on the gas holes and the crack sand interface separation of the sealing layer are reported. The results show that when the laser power reached 80 W at the welding speed of 2 mm/s, the bulk solder disappeared to most of the quantity and the sealing surface density was higher, due to which negligible pores and micro cracks were found. Thus, the sealing quality of the sealing layer is considered to be suitable when the temperature of 470 &deg;C was maintained and the solder has 68.93% of Pb and 3.04% Si in the atom fraction to achieve the wet the glass substrate surface whilst improving the bonding quality