Experimental study of generic billiards with microwave resonators

In this work we study the eigenstates and the energy spectra of a generic billiard system with the use of microwave resonators. This is possible due to the exact correspondence between the Schroedinger equation and the electric field equations of the lowest modes in thin microwave resonators. We obtain a good agreement between the numerical (exact) and experimental eigenstates, while the short range experimental spectral statistics show the expected Brody-like behaviour in this energy range, as opposed to the Berry-Robnik picture which is valid only in the semiclassical region of sufficiently small effective Planck's constant.Comment: 13 pages, 10 figures (in .GIF format), high quality pictures available upon request, PTP LaTeX style, to be published in the proceedings of the conference/summer school 'Let's Face Chaos through Nonlinear Dynamics', Maribor, Slovenia, June/July 1999, eds. M. Robnik et al., Prog. Theor. Phys. Suppl. (Kyoto) 139 (2000

System Structure Risk Metric Method Based on Information Flow

Part 5: Modelling and SimulationInternational audienceThe measurement of structure risk aims to analysis and evaluate the not occurred, potential, and the objectively exist risk in system structure. It is an essential way to validate system function and system quality. This paper proposes the risk metric model and algorithm based on information flow and analysis risk trend between traditional tree structure and network-centric structure

Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study

Background Radix Bupleuri (RB) has been popularly used for treating many liver diseases such as chronic hepatic inflammation and viral Hepatitis in China. Increasing clinical and experimental evidence indicates the potential hepatotoxicity of RB or prescriptions containing RB. Recently, Saikosaponins (SS) have been identified as major bioactive compounds isolated from RB, which may be also responsible for RB-induced liver injury. Methods Serum AST, ALT and LDH levels were determined to evaluate SS-induced liver injury in mice. Serum and liver total triglyceride and cholesterol were used to indicate lipid metabolism homeostasis. Liver ROS, GSH, MDA and iNOS were used to examine the oxidative stress level after SS administration. Western blot was used to detect CYP2E1 expression. A 8-Plex iTRAQ Labeling Coupled with 2D LC - MS/MS technique was applied to analyze the protein expression profiles in livers of mice administered with different doses of SS for different time periods. Gene ontology analysis, cluster and enrichment analysis were employed to elucidate potential mechanism involved. HepG2 cells were used to identify our findings in vitro. Results SS dose- and time-dependently induced liver injury in mice, indicated by increased serum AST, ALT and LDH levels. According to proteomic analysis, 487 differentially expressed proteins were identified in mice administrated with different dose of SS for different time periods. Altered proteins were enriched in pathways such as lipid metabolism, protein metabolism, macro molecular transportation, cytoskeleton structure and response to stress. SS enhanced CYP2E1 expression in a time and dose dependent manner, and induced oxidative stress both in vivo and in vitro. Conclusion Our results identified hepatotoxicity and established dose-time course-liver toxicity relationship in mice model of SS administration and suggested potential mechanisms, including impaired lipid and protein metabolism and oxidative stress. The current study provides experimental evidence for clinical safe use of RB, and also new insights into understanding the mechanism by which SS and RB induced liver injury