Di-μ-chlorido-bis­{aqua­chlorido[3-ethyl-4-phenyl-5-(2-pyrid­yl)-4H-1,2,4-triazole-κ2 N 1,N 5]manganese(II)}

In the centrosymmetric dinuclear title compound, [Mn2Cl4(C15H14N4)2(H2O)2], the MnII atom is coordinated by an N,N′-bidentate ligand, a water mol­ecule, a terminal chloride ion and two bridging chloride ions in a distorted MnN2OCl3 octa­hedral geometry. The Mn⋯Mn separation is 3.6563 (9) Å. In the crystal structure, O—H⋯N and O—H⋯Cl hydrogen bonds help to establish the packing

Bis[4,5-dimethyl-2-(2-pyrid­yl)-1H-imidazole-κ2 N 2,N 3](1H-imidazole-κN 3)copper(II) bis­(perchlorate)

In the title complex, [Cu(C3H4N2)(C10H11N3)2](ClO4)2, the CuII cation has a distorted trigonal-bipyramidal geometry defined by a CuN2N′2N′′ donor set. The imidazole ligand is disordered over two orientations of equal occupancy. Two of the perchlorate ion sites are located on a twofold rotation axis, and one of is disordered over two sites of equal occupancy. In the crystal structure there is a two-dimensional infinite network of hydrogen-bonded mol­ecules parallel to the ab plane

Contractibility of space of stability conditions on the projective plane via global dimension function

We compute the global dimension function $\mathrm{gldim}$ on the principal component $\mathrm{Stab}^{\dag}(\mathbb{P}^2)$ of the space of Bridgeland stability conditions on $\mathbb{P}^2$. It admits $2$ as the minimum value and the preimage $\mathrm{gldim}^{-1}(2)$ is contained in the closure $\overline{\mathrm{Stab}^{\mathrm{Geo}}(\mathbb{P}^2)}$ of the subspace consisting of geometric stability conditions. We show that $\mathrm{gldim}^{-1}[2,x)$ contracts to $\mathrm{gldim}^{-1}(2)$ for any real number $x\geq 2$ and that $\mathrm{gldim}^{-1}(2)$ is contractible.Comment: 26 pages, 7 figures. Add a reference and update Section 4. Comments are welcome

Effect of isopropyl myristate on the viscoelasticity and drug release of a drug-in-adhesive transdermal patch containing blonanserin

AbstractThe purpose of this study was to investigate the effect of isopropyl myristate (IPM), a penetration enhancer, on the viscoelasticity and drug release of a drug-in-adhesive transdermal patch containing blonanserin. The patches were prepared with DURO-TAK® 87-2287 as a pressure-sensitive adhesive (PSA) containing 5% (w/w) of blonanserin and different concentrations of IPM. An in vitro release experiment was performed and the adhesive performance of the drug-in-adhesive patches with different concentrations of IPM was evaluated by a rolling ball tack test and a shear-adhesion test. The glass transition temperature (Tg) and rheological parameters of the drug-in-adhesive layers were determined to study the effect of IPM on the mechanical properties of the PSA. The results of the in vitro release experiment showed that the release rate of blonanserin increased with an increasing concentration of IPM. The rolling ball tack test and shear-adhesion test showed decreasing values with increasing IPM concentration. The results were interpreted on the basis of the IPM-induced plasticization of the PSA, as evidenced by a depression of the glass transition temperature and a decrease in the elastic modulus. In conclusion, IPM acted as a plasticizer on DURO-TAK® 87-2287, and it increased the release of blonanserin and affected the adhesive properties of the PSA

A real time S1 assay at neutral pH based on graphene oxide quenched fluorescence probe

AbstractAs the extracellular nuclease of Aspergillus, S1 nuclease can split single and double-stranded DNA into oligo- or mononucleotides, while preferentially digests single-stranded nucleic acids. Furthermore, the existence of S1 can be the standard to identify Aspergillus and used to evaluate the severity of Aspergillosis. Herein, a simple and sensitive fluorescent sensing platform for S1 assay was developed based on the S1-induced DNA strand scission and the difference in affinity of graphene oxide (GO) for single-stranded DNA containing different bases. This platform was applied to monitor S1 activity and study the kinetics in real time. Results indicated that the detection limit is 0.5U/mL. The Km and kcat at 45°C, are 1.4±0.12μM and 0.6min−1, respectively. Moreover, by monitoring the effect of chemical drugs on S1 activity, we found that 2mM of erythromycin, sodium penicillin, carbenicillin disodium and ampicillin can inhibit S1 activity about 8%, 60%, 61% and 66%, respectively, while gentamycin sulfate is a stimulator. Overall, the assay platform based on graphene oxide quenched fluorescence probe is successfully constructed to study the enzymatic activity of S1 and used for screening antibiotics

Bis[μ-3-ethyl-4-phenyl-5-(2-pyrid­yl)-4H-1,2,4-triazole]bis­[dichloridocopper(II)]

The asymmetric unit of the title compound, [Cu2Cl4(C15H14N4)2], contains two halves of two centrosymmetric dinuclear mol­ecules, A and B. The conformations of the two crystallographically independent mol­ecules are slightly different: in A, the Cu⋯Cu separation is 4.174 (9) Å and the dihedral angle between the triazole and phenyl rings is 74.23 (11)°; these values are 4.137 (9) Å and 68.58 (13)°, respectively, in B. In each mol­ecule, the copper(II) ions have a distorted trigonal–bipyramidal coordination geometry with a CuCl2NN′N′′ chromophore. The crystal packing exhibits weak inter­molecular C—H⋯Cl inter­actions

Spatio-temporal analysis and prediction of cellular traffic in metropolis

ISSN:1536-1233ISSN:1558-066

Ontology-based approach supporting multi-objective holistic decision making for energy pile system

The traditional way of designing energy pile system is mostly single domain/objective oriented, which lacks of means to coherently consider different while relevant factors across domains. The cost for life cycle design, construction and maintenance, return of investment, CO2 emission related sustainable requirements, and so on also need to be considered, in a systematic manner, along with the main functional design objective for loading capacity and robustness. This paper presents a novel multi-objective holistic approach for energy pile system design using ontology based multi-domain knowledge orchestration, which can holistically provide the designers with across domain factors regarding financial, safety, and environmental impact, for smart and holistic consideration during the early design stage. A prototypical ontology-based decision tool has been developed, aiming at the holistic optimization for energy pile system by combining ontology and Semantic Web Rule Language rules. A case study was performed to illustrate the details on how to apply knowledge query to provide a series of design alternatives autonomously by taking different design parameters into account. The method has demonstrated its practicability and scientific feasibility, it also shows the potential to be adopted and extended for other domains when dealing with multi-objective holistic design making